TY  - JOUR
AU  - Lu, Jian
AU  - Hu, Ze-Bo
AU  - Chen, Pei-Pei
AU  - Lu, Chen-Chen
AU  - Zhang, Jia-Xiu
AU  - Li, Xue-Qi
AU  - Yuan, Ben-Yin
AU  - Huang, Si-Jia
AU  - Ma, Kun-Ling
PY  - 2019
TI  - Urinary levels of podocyte-derived microparticles are associated with the progression of chronic kidney disease
JF  - Annals of Translational Medicine; Vol 7, No 18 (September 30, 2019): Annals of Translational Medicine
Y2  - 2019
KW  - 
N2  -  Background:  Podocyte-derived microparticles (MPs) could be secreted from activated or apoptotic podocytes. An increased number of podocyte-derived MPs in the urine might reflect podocyte injury in renal diseases. This study aimed to observe the change of urinary podocyte-derived MP levels in patients with chronic kidney disease (CKD) and to further explore its correlation with the progression of CKD.    Methods:  A prospective, longitudinal study was conducted in eighty patients with biopsy-proven CKD. Podocyte-derived MPs (annexin V and podocalyxin positive) were detected by flow cytometry. The number of urinary podocyte-derived MPs was analyzed to evaluate the association with biochemical measurements and pathological glomerulosclerosis assessment. Patients with idiopathic membranous nephropathy (IMN) were followed up after the six-month treatment of prednisone combined with tacrolimus to evaluate the association of urinary podocyte-derived MP levels and the remission of IMN.   Results:  The CKD patients had higher urinary podocyte-derived MP levels compared with healthy controls (HCs). Baseline urinary levels of podocyte-derived MPs were positively correlated with 24-hour proteinuria, while were inversely correlated with the percentage of global glomerulosclerosis. The urinary podocyte-derived MPs levels had good discrimination for glomerulosclerosis [area under curve (AUC), 0.66]. The urinary podocyte-derived MPs levels in IMN patients were significantly decreased accompanied with the recovery of abnormal clinical parameters after six-month treatment.    Conclusions:  The urinary levels of podocyte-derived MPs were closely associated with podocyte injury and glomerulosclerosis, which could be useful for monitoring disease activity in CKD patients. Urinary podocyte-derived MPs might be a non-invasive biomarker for the evaluation of early CKD progression.
UR  - https://atm.amegroups.org/article/view/29415