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Risk of second primary malignancy after non-small cell lung cancer: a competing risk nomogram based on the SEER database

  
@article{ATM29400,
	author = {Huaqiang Zhou and Jiayi Shen and Yaxiong Zhang and Yan Huang and Wenfeng Fang and Yunpeng Yang and Shaodong Hong and Jiaqing Liu and Wei Xian and Zhonghan Zhang and Yuxiang Ma and Ting Zhou and Hongyun Zhao and Li Zhang},
	title = {Risk of second primary malignancy after non-small cell lung cancer: a competing risk nomogram based on the SEER database},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {18},
	year = {2019},
	keywords = {},
	abstract = {Background: With the improvement of survival for non-small cell lung cancer (NSCLC), research focused on second primary malignancy (SPM) in NSCLC survivors is becoming urgent. This study aimed to estimate the risk of SPM in NSCLC patients.
Methods: We retrospectively analysed NSCLC patients diagnosed between 2004 and 2010 in SEER database. We firstly evaluated the crude and cumulative incidence of SPM. SPM incidence in NSCLC survivors compared to that in the reference population was calculated as standardized incidence ratio (SIR). A competing risk nomogram was also built, to predict the incidence of SPM.
Results: The crude and 10-year cumulative incidences of SPM were 4.04% and 5.05%, respectively, while the SIR was 1.62. The nomogram was well calibrated and had good discriminative ability, with c-index of 0.80. It showed a significantly wide interval of SPM cumulative incidence between the first and tenth-decile according to the risk model (1.04% vs. 16.70%, P},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/29400}
}