TY - JOUR AU - Cremolini, Chiara AU - Moretto, Roberto AU - Zucchelli, Gemma AU - Falcone, Alfredo PY - 2019 TI - BRAF mutant metastatic colorectal cancers: new arrows in our quiver JF - Annals of Translational Medicine; Vol 7, Supplement 8 (December 31, 2019): Annals of Translational Medicine Y2 - 2019 KW - N2 - BRAF mutations occur in 8–12% of metastatic colorectal cancers (mCRC) and more than 95% of them consist in a T>A transversion in exon 15 resulting in an amino acid substitution from valine to glutamic acid (V600E) that is able to increase BRAF kinase activity by approximately 10-fold (1,2). UR - https://atm.amegroups.org/article/view/28956