TY - JOUR AU - Huang, Qinghua AU - Fei, Xianming AU - Li, Shengbing AU - Xu, Chan AU - Tu, Chunping AU - Jiang, Lei AU - Wo, Mingyi PY - 2019 TI - Predicting significance of COX-2 expression of peripheral blood monocyte in patients with coronary artery disease JF - Annals of Translational Medicine; Vol 7, No 18 (September 30, 2019): Annals of Translational Medicine Y2 - 2019 KW - N2 - Background: Cyclooxygenase-2 (COX-2) plays an important role in the monocyte-platelet aggregate (MPA)-medicated inflammatory response and possible coronary artery disease (CAD). This study aimed to assess the predicting significance of COX-2 expression in peripheral blood monocyte for CAD. Methods: A total of 66 patients with CAD including stable angina (SA) and unstable angina (UA) were enrolled. The inflammatory indexes including white blood cell (WBC) count, high-sensitive C reactive protein (hs-CRP), serum monocyte chemoattractant protein-1 (MCP-1) and MPA levels were measured. The western-blotting assay and reverse transcription-polymerase chain reaction (RT-PCR) analysis were used to detect the COX-2 expression in peripheral blood monocytes. Furthermore, the correlation between COX-2 expression and MPA levels, and the association of COX-2 expression with CAD risk were assessed. Results: The UA patients demonstrated higher levels of inflammatory indexes than the SA patients (P 2 =0.4933, P Conclusions: The COX-2 expression of peripheral blood monocytes can be used as an independent predictor for CAD. UR - https://atm.amegroups.org/article/view/28744