@article{ATM28744,
author = {Qinghua Huang and Xianming Fei and Shengbing Li and Chan Xu and Chunping Tu and Lei Jiang and Mingyi Wo},
title = {Predicting significance of COX-2 expression of peripheral blood monocyte in patients with coronary artery disease},
journal = {Annals of Translational Medicine},
volume = {7},
number = {18},
year = {2019},
keywords = {},
abstract = {Background: Cyclooxygenase-2 (COX-2) plays an important role in the monocyte-platelet aggregate (MPA)-medicated inflammatory response and possible coronary artery disease (CAD). This study aimed to assess the predicting significance of COX-2 expression in peripheral blood monocyte for CAD.
Methods: A total of 66 patients with CAD including stable angina (SA) and unstable angina (UA) were enrolled. The inflammatory indexes including white blood cell (WBC) count, high-sensitive C reactive protein (hs-CRP), serum monocyte chemoattractant protein-1 (MCP-1) and MPA levels were measured. The western-blotting assay and reverse transcription-polymerase chain reaction (RT-PCR) analysis were used to detect the COX-2 expression in peripheral blood monocytes. Furthermore, the correlation between COX-2 expression and MPA levels, and the association of COX-2 expression with CAD risk were assessed.
Results: The UA patients demonstrated higher levels of inflammatory indexes than the SA patients (P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/28744}
}