%0 Journal Article %T Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events %A Bhattad, Venugopal B. %A Gaddam, Sathvika %A Lassiter, Margaret A. %A Jagadish, Pooja S. %A Ardeshna, Devarshi %A Cave, Brandon %A Khouzam, Rami N. %J Annals of Translational Medicine %D 2019 %B 2019 %9 %! Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events %K %X Cangrelor is a relatively new antiplatelet drug that has been approved for use as an adjunct therapy to percutaneous coronary intervention (PCI) to decrease peri-procedural myocardial infarction (MI), coronary revascularization, and stent thrombosis. Cangrelor is an adenosine triphosphate analogue with a pharmacokinetic mechanism based on a reversible, dose-dependent inhibition adenosine diphosphate (ADP)-induced platelet aggregation. This drug has lately been in the spotlight as a possible bridge therapy for anti-platelet medication prior to cardiac and non-cardiac surgeries. Platelet function is usually restored within sixty minutes of cessation of therapy, thereby decreasing the risk of bleeding while providing adequate pre-procedural coverage to reduce ischemic events. This manuscript reviews the literature on cangrelor and summarizes its role as a peri-procedural bridge. %U https://atm.amegroups.org/article/view/28054 %V 7 %N 17 %P 408 %@ 2305-5847