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Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery

  
@article{ATM26673,
	author = {Richard W. Olsen and A. Kerstin Lindemeyer and Martin Wallner and Xiaorun Li and Kevin W. Huynh and Z. Hong Zhou},
	title = {Cryo-electron microscopy reveals informative details of GABA A  receptor structural pharmacology: implications for drug discovery},
	journal = {Annals of Translational Medicine},
	volume = {0},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {The first cryoEM high-resolution structure of a recombinant full-length heterotrimeric γ-aminobutyric acid (GABA) type A receptor (GABAR) subtype α1β3γ2L in complex with important GABAR ligands was published by the Aricescu lab in January 2019 (1,2). GABARs are the major receptors mediating rapid inhibitory neurotransmission in the central nervous system and members of the pentameric ligand-gated ion channel (pLGIC) gene superfamily.},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/26673}
}