TY - JOUR AU - Zhu, Qi AU - Shan, Chang AU - Li, Ling AU - Song, Lige AU - Zhang, Keqin AU - Zhou, Yun PY - 2019 TI - Differential expression of genes associated with hypoxia pathway on bone marrow stem cells in osteoporosis patients with different bone mass index JF - Annals of Translational Medicine; Vol 7, No 14 (July 31, 2019): Annals of Translational Medicine Y2 - 2019 KW - N2 - Background: This study aimed to assess gene expression changes associated with hypoxia pathway on bone marrow stem cells (BMSCs) and explore effects of bone mass index (BMI) on hypoxia pathway of osteoporosis (OP) patients. Methods: Human BMSCs were isolated from bone marrow. Subjects were divided into healthy control group and OP group which was further divided into BMI Results: The genes downregulated in OP patients were involved in hypoxia pathway. Furthermore, those genes were even downregulated in OP patients BMI ≥25 subgroup than OP patients BMI Conclusions: The expression of genes associated with hypoxia pathway on BMSCs in OP patients are lower than healthy subjects, and the expression of genes related to carbohydrate metabolism are lower in overweight OP patients than in normal weight OP patients. These results need further research. UR - https://atm.amegroups.org/article/view/26646