%0 Journal Article %T New insights in predictive determinants of the tumor immune microenvironment for immune checkpoint inhibition: a never ending story? %A Eckstein, Markus %A Gupta, Shilpa %J Annals of Translational Medicine %D 2019 %B 2019 %9 %! New insights in predictive determinants of the tumor immune microenvironment for immune checkpoint inhibition: a never ending story? %K %X Checkpoint inhibitors such as Pembrolizumab (Keytruda ® , MSD), Atezolizumab (Tecentriq ® , Roche), Durvalumab (Imfinzi ® , AstraZeneca) or Nivolumab (Opdivo ® , BMS) have significantly improved curative and palliative treatment of solid malignancies (1-4). However, clinical responses vary largely across different tumor entities. Since the currently used standard predictive tool—PD-L1 assessment by immunohistochemistry—shows largely varying predictive efficacy in different tumor types, e.g., in urothelial cancer (5-7), there is a heavy need for additional complementary biomarkers which can improve the current immunotherapy selection and prediction of therapy success. %U https://atm.amegroups.org/article/view/26472 %P S135 %@ 2305-5847