%0 Journal Article %T Progress in interferon-gamma release assay development and applications: an unfolding story of translational research %A Lalvani, Ajit %A Whitworth, Hilary S. %J Annals of Translational Medicine %D 2019 %B 2019 %9 %! Progress in interferon-gamma release assay development and applications: an unfolding story of translational research %K %X The introduction of blood-based tests for M. tuberculosis ( Mtb ) infection approximately 15 years ago was a turning point for diagnosis of latent tuberculosis (TB). Interferon-gamma release assays (IGRAs), which measure Mtb antigen-specific T cell responses, include the ELISpot-based T-SPOT.TB (Oxford Immunotec, Abingdon, UK) and the ELISA-based QuantiFERON Gold In-Tube (QFT-GIT; Qiagen, Hilden, Germany). %U http://atm.amegroups.com/article/view/26457 %P %@ 2305-5847