TY - JOUR AU - Deng, Han-Yu AU - Zheng, Xi AU - Jiang, Rui AU - Wang, Rui-Lan AU - Zhou, Jie AU - Qiu, Xiao-Ming PY - 2019 TI - Preoperative D-dimer level is an independent prognostic factor for non-small cell lung cancer after surgical resection: a systematic review and meta-analysis JF - Annals of Translational Medicine; Vol 7, No 16 (August 28, 2019): Annals of Translational Medicine Y2 - 2019 KW - N2 - Background: Whether high preoperative D-dimer level has any impact on long-term survival of patients with surgically treated non-small cell lung cancer (NSCLC) remains unclear. Therefore, we conducted the first meta-analysis focusing specifically on prognostic value of high preoperative D-dimer level in NSCLC patients after surgical resection comprehensively. Methods: We conducted a systematic search for relevant studies in PubMed, Embase, and Web of Science on January 28, 2019. Data for analysis consisted of hazard ratio (HR) with 95% confidence interval (CI) of overall survival (OS) and disease-free survival (DFS) from multivariate analysis and were analyzed by using the STATA 12.0 package. Results: Finally, we included a total of 6 cohort studies consisting of 1,817 patients with surgically treated NSCLC for analysis. Our meta-analysis found that NSCLC patients with high preoperative D-dimer level had a significantly worse OS (random effects: HR =2.04; 95% CI: 1.30–3.20; P=0.002; I 2 =67.4%) and DFS (fixed effects: HR =1.98; 95% CI: 1.41–2.78; P 2 =0.0%) than these with normal preoperative D-dimer level after surgery. However, potential heterogeneity and publication bias was observed during analysis. Conclusions: High pretreatment level of D-dimer remains to be an independent predictor of poor prognosis in NSCLC patients after surgery. Further well-conducted studies with appropriate adjustments are needed to confirm and update our conclusions. UR - https://atm.amegroups.org/article/view/26377