How to cite item

Modification of the tumor response threshold in patients of advanced non-small cell lung cancer treated with chemotherapy plus targeted agents: a pooled study from five clinical trials in one institution

  
@article{ATM25636,
	author = {Fan Luo and Zhonghan Zhang and Kunlun Liao and Yang Zhang and Yuxiang Ma and Zhihuang Hu and Kangmei Zeng and Yan Huang and Li Zhang and Hongyun Zhao},
	title = {Modification of the tumor response threshold in patients of advanced non-small cell lung cancer treated with chemotherapy plus targeted agents: a pooled study from five clinical trials in one institution},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {12},
	year = {2019},
	keywords = {},
	abstract = {Background: Chemotherapy with targeted therapy is a promising therapeutic option for advanced non-small cell lung cancer (NSCLC) patients. Response Evaluation Criteria in Solid Tumors (RECIST) criteria were used in tumor response evaluation. We assumed an optimal threshold for this therapeutic setting and tried to seek a new tumor shrinkage cutoff with the data from five clinical trials in one institution. 
Methods: The X-tile program was used to identify the optimal cut-off value of tumor shrinkage. PFS and OS were compared in the current study. Kaplan-Meier method was used to describe PFS and OS. 95% CI was calculated for PFS and OS outcomes to assess the treatment efficacy. A P value of less than 0.05 was considered statistically significant. SPSS 23.0 was used for all statistical analysis. 
Results: X-tile analysis yielded −10% in the ∆SLD of the target lesions as the optimal threshold for response/non-response. The 10% tumor shrinkage could discriminate responders from non-responders in PFS (10.1 vs. 2.50 months, P=0.0007) and OS (23.00 vs. 7.66 months, P},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/25636}
}