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Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required

   
@article{ATM24425,
	author = {Nicolas Jonckheere and Isabelle Van Seuningen},
	title = {Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {Suppl 1},
	year = {2019},
	keywords = {},
	abstract = {Autophagy is a physiological process of cellular component recycling promoting cell survival and homeostasis under unfavorable conditions. Pancreatic ductal adenocarcinoma (PDAC) (90–95% of pancreatic cancer) has been associated with multiple metabolic alterations including autophagy. Because of its supporting role in tumor growth, inhibition of autophagy has been proposed as a treatment of pancreatic cancer (1,2). Autophagy process is regulated by autophagy-related proteins (ATGs) necessary for the autophagosome formation and subsequent delivering of cytoplasmic content for degradation by lysosomes. Among these proteins, Atg5 is a key player for autophagy onset but little is known about its role in tumorigenesis (3).},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/24425}
}