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Recent fluorescence-based optical imaging for video-assisted thoracoscopic surgery segmentectomy

	author = {Yosuke Matsuura and Mingyon Mun and Junji Ichinose and Masayuki Nakao and Ken Nakagawa and Sakae Okumura},
	title = {Recent fluorescence-based optical imaging for video-assisted thoracoscopic surgery segmentectomy},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {2},
	year = {2019},
	keywords = {},
	abstract = {Background: The importance of fluorescence-based optical imaging in various fields of surgery is increasing. This is a prospective cohort study aimed to investigate the feasibility and efficacy of indocyanine-green fluorescence (ICGF)-based navigation for near-infrared (NIR) thoracoscopic segmentectomy. 
Methods: ICGF-based video-assisted thoracoscopic surgery (VATS) segmentectomy was performed in 149 patients. Each patient underwent preoperative evaluation by multidetector-row computed tomography (MDCT), which provided three-dimensional simulations of vascular structures, segmental bronchi, and lung tumor. During the procedure, low-dose ICG (0.25 mg/kg) was injected systemically after the target segmental pulmonary arteries and bronchus were divided. Under NIR-thoracoscopic guidance, an ICG fluorescent line was marked by electric scalpel, followed by division of lung parenchyma along the line by electric scalpel or endoscopic staples.
Results: An intersegmental line of ICGF was visible in 98% of patients, even with the use of low-dose ICG. Neither ICG-related adverse events nor procedure-related major complications occurred. The 5-year overall (OS) and recurrence-free survival (RFS) rates were 91.8% and 98%, respectively. Localized recurrence at the resected site did not occur in any patient.
Conclusions: ICGF-based navigation for NIR VATS segmentectomy for patients with lung cancer is feasible and effective.},
	issn = {2305-5847},	url = {}