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Central nervous system activity of first-line osimertinib in epidermal growth factor receptor-mutant advanced non-small cell lung cancer

   
@article{ATM23427,
	author = {Chong-Kin Liam},
	title = {Central nervous system activity of first-line osimertinib in epidermal growth factor receptor-mutant advanced non-small cell lung cancer},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {3},
	year = {2019},
	keywords = {},
	abstract = {Although the majority of patients with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)- sensitizing mutations experience good initial response to first‑generation (erlotinib, gefitinib) and second-generation (afatinib, dacomitinib) EGFR-TKIs, they invariably suffer disease progression either due to a pharmacodynamic resistance to the EGFR-TKI or a pharmacokinetic failure resulting in central nervous system (CNS) progression (1-3).},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/23427}
}