%0 Journal Article %T Upfront osimertinib in EGFR -mutated non-small cell lung cancer: is brain still a sanctuary? %A Leonetti, Alessandro %A Facchinetti, Francesco %A Tiseo, Marcello %J Annals of Translational Medicine %D 2018 %B 2018 %9 %! Upfront osimertinib in EGFR -mutated non-small cell lung cancer: is brain still a sanctuary? %K %X In the last 10 years, the prognosis of advanced non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor ( EGFR ) mutations has dramatically improved, since the introduction of selective EGFR-tyrosine kinase inhibitors (TKIs). %U https://atm.amegroups.org/article/view/22757 %P S110 %@ 2305-5847