@article{ATM22706,
author = {Yuyong Tan and Shilan Zhang and Hongyi Zhu and Yi Chu and Hejun Zhou and Deliang Liu and Jirong Huo},
title = {Histone deacetylase 6 selective inhibitor ACY1215 inhibits cell proliferation and enhances the chemotherapeutic effect of 5-fluorouracil in HCT116 cells},
journal = {Annals of Translational Medicine},
volume = {7},
number = {1},
year = {2018},
keywords = {},
abstract = {Background: ACY1215 is a selective histone deacetylase 6 (HDAC6) inhibitor, and can suppress tumor growth for many human cancers. However, its role in colon cancer and its impact on the chemotherapeutic effect of 5-fluorouracil (5-Fu) are largely unknown. The aim of the present study is to explore the effect of ACY1215 on cell growth, migration, invasion and apoptosis, along with its impact on the chemotherapeutic effect of 5-Fu in HCT116 cells.
Methods: HCT116 cells were treated with ACY1215 with or without 5-Fu, and cell viability, proliferation, migration, invasion and apoptosis were explored.
Results: The cell viability, colony formation number, wound closure rate, and migrated cell numbers of HCT116 cells significantly decreased, while the apoptotic cells significantly increased with the increased concentration of ACY1215 (P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/22706}
}