TY - JOUR AU - Che-Nordin, Nazmi AU - Deng, Min AU - Griffith, James F. AU - Leung, Jason C. S. AU - Kwok, Anthony W. L. AU - Zhu, Yue-Qi AU - So, Richard H. Y. AU - Kwok, Timothy C. Y. AU - Leung, Ping Chung AU - Wáng, Yì Xiáng J. PY - 2018 TI - Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males JF - Annals of Translational Medicine; Vol 6, No 22 (November 20, 2018): Annals of Translational Medicine Y2 - 2018 KW - N2 - Background: While the importance of identifying osteoporotic vertebral endplate fracture (EPF) is being recognized; the pathophysiological understanding of EPF till now remain insufficient. In this population-based cross-sectional radiograph study, we aim to investigate the anatomic location characteristics of osteoporotic EPF. Methods: This study analyzed the anatomical location of osteoporotic EPFs in elderly Chinese population (age ≥65 years). The T4–L4 radiographs of 1,954 elderly Chinese men (mean: 72.3 years) and 1,953 elderly Chinese women (mean: 72.5 years) were evaluated to identify EPF, and vertebral bodies were graded according to Genant’s vertebral deformity criteria. Results: Of the 101,582 endplates analyzed, there were 505 EPFs (males: 27.7%; females: 72.3%). Excluding those with both upper endplate and lower endplate involvements, the ratio of upper EPF to lower EPF was 9.63 for males and 4.3 for females (P Conclusions: Osteoporotic EPFs more likely involve the upper endplate rather than lower endplate, with a trend for this effect to be greater in men than in women. These characteristics may help radiographic differential diagnosis for osteoporotic EPF. UR - https://atm.amegroups.org/article/view/22209