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The different path of T790M-positive EGFR-mutant lung cancer

  
@article{ATM21864,
	author = {Shinkyo Yoon and Chang Min Choi and Jae Cheol Lee},
	title = {The different path of T790M-positive EGFR-mutant lung cancer},
	journal = {Annals of Translational Medicine},
	volume = {0},
	number = {0},
	year = {2018},
	keywords = {},
	abstract = {Approximately half of the cases of acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are mediated by the secondary T790M mutation (1,2). Distinct clinical course of patients with T790M-positive lung cancer has been suggested, mostly in the context of more indolent progression and favorable prognosis (3,4). It is in line with the pre-clinical study showing that EGFR-mutant cell lines with acquired T790M mutation exhibit slower growth although the way how the additional T790M mutation can affect the growth rate of EGFR-mutant lung cancer cells remains unclear (5).},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/21864}
}