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Non-invasive assessment of tumor PD-L1 status with circulating tumor cells

  
@article{ATM21814,
	author = {Bryan C. Ulrich and Nicolas Guibert},
	title = {Non-invasive assessment of tumor PD-L1 status with circulating tumor cells},
	journal = {Annals of Translational Medicine},
	volume = {0},
	number = {0},
	year = {2018},
	keywords = {},
	abstract = {Now FDA-approved in the treatment of over ten malignancies, checkpoint blockade agents have transformed the treatment of cancer. These agents work by inhibiting the PD-1/PD-L1 interaction between cytotoxic T cells and tumor cells, an interaction which promotes immune evasion. PD-L1 expression levels by tumor cells, as assessed by tissue biopsy, is currently the most well-validated and clinically used predictive biomarker of response to checkpoint blockade agents (1,2). However, PD-L1 level is known to be an imperfect biomarker, and some FDA approvals do not set a PD-L1 expression level threshold to determine patient candidacy for checkpoint blockade.},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/21814}
}