%0 Journal Article %T Rare diseases: the paradox of an emerging challenge %A Danese, Elisa %A Lippi, Giuseppe %J Annals of Translational Medicine %D 2018 %B 2018 %9 %! Rare diseases: the paradox of an emerging challenge %K %X Rare (often called “orphan”) diseases are conventionally defined as those affecting a very low number of individuals, but which can be associated with inappropriate management, chronic debilitation and adverse health outcome, up to death. %U https://atm.amegroups.org/article/view/21158 %V 6 %N 17 %P 329 %@ 2305-5847