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ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

  
@article{ATM20769,
	author = {Fang-Chen Ma and Yu Zong and Hui-Fu Wang and Jie-Qiong Li and Xi-Peng Cao and Lan Tan and Alzheimer’s Disease Neuroimaging Initiative},
	title = {ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia},
	journal = {Annals of Translational Medicine},
	volume = {6},
	number = {22},
	year = {2018},
	keywords = {},
	abstract = {Background: ATP-binding cassette transporter A7 (ABCA7) rs3764650 has been identified to be a susceptibility locus for Alzheimer’s disease (AD), but its role in cerebrospinal fluid (CSF) proteins was still unclear. 
Methods: The associations of rs3764650 with CSF Aβ1–42, t-tau and p-tau were analyzed in non-dementia AD, including preclinical and prodromal AD from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort.
Results: Finally, GG + GT genotypes significantly decreased CSF Aβ1–42 level, but did not alter CSF t-tau and p-tau levels in non-dementia AD at baseline, which was further confirmed in longitudinal studies. 
Conclusions: Our findings supported that ABCA7 modified AD risk by altering Aβ deposition rather than tau pathology.},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/20769}
}