@article{ATM20769,
author = {Fang-Chen Ma and Yu Zong and Hui-Fu Wang and Jie-Qiong Li and Xi-Peng Cao and Lan Tan and Alzheimer’s Disease Neuroimaging Initiative},
title = {ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia},
journal = {Annals of Translational Medicine},
volume = {6},
number = {22},
year = {2018},
keywords = {},
abstract = {Background: ATP-binding cassette transporter A7 (ABCA7) rs3764650 has been identified to be a susceptibility locus for Alzheimer’s disease (AD), but its role in cerebrospinal fluid (CSF) proteins was still unclear.
Methods: The associations of rs3764650 with CSF Aβ1–42, t-tau and p-tau were analyzed in non-dementia AD, including preclinical and prodromal AD from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort.
Results: Finally, GG + GT genotypes significantly decreased CSF Aβ1–42 level, but did not alter CSF t-tau and p-tau levels in non-dementia AD at baseline, which was further confirmed in longitudinal studies.
Conclusions: Our findings supported that ABCA7 modified AD risk by altering Aβ deposition rather than tau pathology.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/20769}
}