@article{ATM20472,
author = {Yu-Shang Yang and Yun-Cang Wang and Han-Yu Deng and Yong Yuan and Zhi-Qiang Wang and Du He and Long-Qi Chen},
title = {Prognostic value of circumferential resection margin in T3N0M0 esophageal squamous cell carcinoma},
journal = {Annals of Translational Medicine},
volume = {6},
number = {15},
year = {2018},
keywords = {},
abstract = {Background: The prognostic value of positive circumferential resection margins (CRM) in resected esophageal squamous cell carcinoma (ESCC) is unclear. The Royal College of Pathologists criteria and the College of American Pathologists criteria are the two commonly used definitions of CRM involvement. The aim of this report was to compare the prognostic performance of the two criteria and to propose a modified stratification in patients who underwent radical esophagectomy for ESCC.
Methods: We retrospectively reviewed 112 patients with pathologically confirmed T3N0M0 ESCC and without neoadjuvant therapy from June 2009 and July 2011. The optimal cutoff point was obtained by the X-tile. The prognostic performance of different classifications of CRM was assessed in terms of homogeneity, discriminatory ability, and monotonicity.
Results: According to the Royal College of Pathologists criteria, a positive CRM was detected in 87 patients (77.7%); and 24 patients (21.4%) were found with positive CRM according to the College of American Pathologists criteria. Non-significant associations between overall survival and CRM were observed according to either of the two criteria. The analysis of reclassifying the CRM criteria demonstrated that the optimal cutoff CRM value for best prognostic power was 600 μm. Patients with CRM more than 600 μm showed better overall survival (P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/20472}
}