%0 Journal Article %T Blood pressure targets for hypertension in patients with type 2 diabetes %A Aronow, Wilbert S. %A Shamliyan, Tatyana A. %J Annals of Translational Medicine %D 2018 %B 2018 %9 %! Blood pressure targets for hypertension in patients with type 2 diabetes %K %X Background: Clinical guidelines vary in determining optimal blood pressure targets in adults with diabetes mellitus. Methods: We systematically searched PubMed, EMBASE, Cochrane Library, and clinicaltrials.gov in March 2018; conducted random effects frequentist meta-analyses of direct aggregate data; and appraised the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Results: From eligible 14 meta-analyses and 95 publications of randomized controlled trials (RCT), only 6 RCTs directly compared lower versus higher blood pressure targets; remaining RCTs aimed at comparative effectiveness of hypotensive drugs. In adults with diabetes mellitus and elevated systolic blood pressure (SBP), direct evidence (2 RCTs) suggests that intensive target SBP Conclusions: We concluded that in adults with diabetes mellitus and arterial hypertension, in order to reduce the risk of stroke, clinicians should target blood pressure at 120–130/80 mmHg, with close monitoring for all drug-related harms. %U https://atm.amegroups.org/article/view/19890 %V 6 %N 11 %P 199 %@ 2305-5847