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Association of lectin-like oxidized low density lipoprotein receptor 1 (OLR1) polymorphisms with late-onset Alzheimer disease in Han Chinese

  
@article{ATM19329,
	author = {Zuo-Teng Wang and Xiao-Ling Zhong and Meng-Shan Tan and Hui-Fu Wang and Chen-Chen Tan and Wei Zhang and Zhan-Jie Zheng and Ling-Li Kong and Lan Tan and Li Sun},
	title = {Association of lectin-like oxidized low density lipoprotein receptor 1 ( OLR1 ) polymorphisms with late-onset Alzheimer disease in Han Chinese},
	journal = {Annals of Translational Medicine},
	volume = {6},
	number = {10},
	year = {2018},
	keywords = {},
	abstract = {Background: Lectin-like oxidized low density lipoprotein receptor 1 (OLR1) locates within the area of chromosome 12p, which has been identified as the AD-susceptible region, and plays a role in lipid metabolism. Therefore, it has been suggested to be a good candidate gene for Alzheimer’s disease (AD). Several SNPs within OLR1 have been reported to have association with AD among Caucasians. 
Methods: We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese.
Results: No significant association was found between the OLR1 (rs1050283, rs1050286, rs17808009) polymorphisms and LOAD, even after adjustment for gender and age and stratification for apolipoprotein E (APOE) status.
Conclusions: Our study showed that the SNPs (rs1050283, rs1050286, rs17808009) located in the 3’UTR of OLR1 may not involve in the mechanism of LOAD in Han Chinese population.},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/19329}
}