%0 Journal Article
%T Impact of smoking in patients undergoing transcatheter aortic valve replacement
%A Agarwal, Manyoo
%A Agrawal, Sahil
%A Garg, Lohit
%A Reed, Guy L.
%A Khouzam, Rami N.
%A Ibebuogu, Uzoma N.
%J Annals of Translational Medicine
%D 2017
%B 2017
%9 
%! Impact of smoking in patients undergoing transcatheter aortic valve replacement
%K 
%X  Background:  The paradox that smokers have better clinical outcomes in cardiovascular diseases remains controversial. No literature exists studying impact of smoking on outcomes following transcatheter aortic valve replacement (TAVR).           Methods:  We performed an electronic search of the 2011–2012 National Inpatient Sample (NIS) database to identify all TAVR hospitalizations. Outcomes were measured comparing smokers to non-smokers.           Results:  A total of 8,345 TAVR hospitalizations were identified with 24% being smokers. Compared to non-smokers, smokers were younger (80.4±8.8  vs.  81.4±9.2 years, P<0.001), were more often men (63.6%  vs.  47.8%, P<0.001), and had a higher disease burden. Despite a higher disease burden, smokers had lower post procedure stroke (2.8%  vs.  3.1%), hemorrhage events (28.2%  vs.  32.0%, P<0.05) and lower all cause in-hospital mortality (1.2%  vs.  5.7%, adjusted odds ratio 0.21, 95% CI: 0.13–0.32, P<0.001) compared to non-smokers.           Conclusions:  Despite having a higher cardiovascular disease burden, smokers had better outcomes compared to non-smokers. Therefore the smoker’s paradox is applicable in the TAVR cohort.
%U https://atm.amegroups.org/article/view/17553
%V 6
%N 1
%P 2
%@ 2305-5847