TY - JOUR AU - Moris, Demetrios AU - Spartalis, Michael AU - Spartalis, Eleftherios AU - Karachaliou, Georgia-Sofia AU - Karaolanis, Georgios I. AU - Tsourouflis, Gerasimos AU - Tsilimigras, Diamantis I. AU - Tzatzaki, Eleni AU - Theocharis, Stamatios PY - 2017 TI - The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox JF - Annals of Translational Medicine; Vol 5, No 16 (August 11, 2017): Annals of Translational Medicine Y2 - 2017 KW - N2 - Acute and chronic excessive intracellular increase of reactive oxygen species (ROS) is involved in the development and progression of cardiovascular diseases. ROS are by-products of various oxidative physiological and biochemical processes. Sources of ROS are mitochondrial respiration, NADH/NADPH oxidase, xanthine oxidoreductase or the uncoupling of nitric oxide synthase (NOS) in vascular cells. ROS mediate various signaling pathways that underlie cardiovascular pathophysiology. The delicate equilibrium between free-radical generation and antioxidant defense is altered in favor of the former, thus leading to redox imbalance, oxidative stress, and increased cellular injury. An understanding of the pathophysiological mechanisms mediated by oxidative stress is crucial to the prevention and treatment of cardiovascular diseases. UR - https://atm.amegroups.org/article/view/16040