@article{ATM13754,
author = {Sylvia Mahara and Ron Firestein},
title = {Targeting the seeds of small cell lung cancer},
journal = {Annals of Translational Medicine},
volume = {5},
number = {5},
year = {2017},
keywords = {},
abstract = {The concept of antibody drug conjugates (ADCs), which includes the delivery of cytotoxic drugs to antigen-expressing tumor cells by harnessing the antigen-selectivity of a monoclonal antibody, has the potential to redefine the landscape of translational medicine. With the advent of patient derived xenograft (PDX) models and sophisticated genomic technologies, the identification of a selective antigen can be accurately validated within the appropriate tumor milieu. However, a major biological hurdle in cancer translational medicine is the inherent tumoral heterogeneity, underscoring the importance of targeting the ‘right’ sub-population of cancer cells. Herein, we review a seminal work highlighting the ability to target a key ‘stem-like’ cancer sub-population called tumor initiating cells (TICs) using engineered ADCs. While the promise of this approach needs to be validated in the clinical setting, TIC-targeted ADCs offer great hope for circumventing current limitations with conventional ADC therapy.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/13754}
}