TY - JOUR AU - Hatch, Marguerite PY - 2017 TI - Gut microbiota and oxalate homeostasis JF - Annals of Translational Medicine; Vol 5, No 2 (January 19, 2017): Annals of Translational Medicine (Focus on “The Human Microbiome in Urologic Health and Disease”, dedicated to a symposium of the American Urological Association Office of Research) Y2 - 2017 KW - N2 - This perspective focuses on how the gut microbiota can impact urinary oxalate excretion in the context of hyperoxaluria, a major risk factor in kidney stone disease. In the genetic disease of Primary Hyperoxaluria Type 1 (PH1), an increased endogenous production of oxalate, due to a deficiency of the liver enzyme alanine-glyoxylate aminotransferase (AGT), results in hyperoxaluria and oxalate kidney stones. The constant elevation in urinary oxalate in PH1 patients ultimately leads to tissue deposition of oxalate, renal failure and death and the only known cure for PH1 is a liver or liver-kidney transplant. The potential impact of a probiotic/therapeutic approach may be clinically significant in PH1 and could also extend to a much larger population of idiopathic oxalate stone formers who comprise ~12% of Americans, individuals with enteric hyperoxaluria, and an emerging population of hyperoxaluric patients who have undergone bariatric surgery and develop kidney stone disease as a consequence. UR - https://atm.amegroups.org/article/view/13316