%0 Journal Article %T MET: roles in epithelial-mesenchymal transition and cancer stemness %A Jeon, Hye-Min %A Lee, Jeongwu %J Annals of Translational Medicine %D 2017 %B 2017 %9 %! MET: roles in epithelial-mesenchymal transition and cancer stemness %K %X In a number of cancers, deregulated MET pathway leads to aberrantly activated proliferative and invasive signaling programs that promote malignant transformation, cell motility and migration, angiogenesis, survival in hypoxia, and invasion. A better understanding of oncogenic MET signaling will help us to discover effective therapeutic approaches and to identify which tumors are likely to respond to MET-targeted cancer therapy. In this review, we will summarize the roles of MET signaling in cancer, with particular focus on epithelial-mesenchymal transition (EMT) and cancer stemness. Then, we will provide update on MET targeting agents and discuss the challenges that should be overcome for the development of an effective therapy. %U https://atm.amegroups.org/article/view/13245 %V 5 %N 1 %P 5 %@ 2305-5847