How to cite item

MET: roles in epithelial-mesenchymal transition and cancer stemness

	author = {Hye-Min Jeon and Jeongwu Lee},
	title = {MET: roles in epithelial-mesenchymal transition and cancer stemness},
	journal = {Annals of Translational Medicine},
	volume = {5},
	number = {1},
	year = {2017},
	keywords = {},
	abstract = {In a number of cancers, deregulated MET pathway leads to aberrantly activated proliferative and invasive signaling programs that promote malignant transformation, cell motility and migration, angiogenesis, survival in hypoxia, and invasion. A better understanding of oncogenic MET signaling will help us to discover effective therapeutic approaches and to identify which tumors are likely to respond to MET-targeted cancer therapy. In this review, we will summarize the roles of MET signaling in cancer, with particular focus on epithelial-mesenchymal transition (EMT) and cancer stemness. Then, we will provide update on MET targeting agents and discuss the challenges that should be overcome for the development of an effective therapy.},
	issn = {2305-5847},	url = {}