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Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

  
@article{ATM13073,
	author = {Karen K. Sayal and Geoffrey S. Higgins and Ester M. Hammond},
	title = {Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity},
	journal = {Annals of Translational Medicine},
	volume = {4},
	number = {24},
	year = {2016},
	keywords = {},
	abstract = {Gliomas are the most frequently occurring brain tumour, of which glioblastomas (WHO grade IV gliomas) are the most common subtype and carry a particularly poor prognosis, leading to 5-year survival rates of just 9.8% (1,2). Radiation is an effective treatment modality although dose escalation is limited by the narrow therapeutic index. Consequently, there is a clear and unmet clinical need for effective radiosensitisation strategies for glioblastoma which enhance anti-tumour efficacy without increasing dose-limiting normal tissue toxicity. The paucity of effective clinically validated radiosensitisers further highlights the need for novel therapeutic targets for radiosensitisation of glioblastoma.},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/13073}
}