TY - JOUR AU - Radhakrishnan, Ashalatha PY - 2016 TI - Polytherapy as first-line in status epilepticus: should we change our practice? “Time is brain”! JF - Annals of Translational Medicine; Vol 4, No 24 (December 29, 2016): Annals of Translational Medicine Y2 - 2016 KW - N2 - Status epilepticus (SE) is one of the most common neurologic emergencies, and is associated with significant mortality ranging from 3% to 40% in various studies (1). “Time is brain” is as important in SE as in any vascular neurologic emergencies since early and prompt treatment offers better outcome. Two decades ago in a pivotal study, Lowenstein et al . demonstrated that seizures are easier to control if treatment is initiated earlier (2). Current guidelines recommend a step-wise approach using different antiepileptic drugs (AEDs) with benzodiazepines (BZDs) being the first-line treatment. To provide a more effective and rapid treatment at the earliest, there are suggestions using more than one drug as first-line treatment, especially in a pre-hospital setting outside the premise of a hospital (3). UR - https://atm.amegroups.org/article/view/12575