TY - JOUR AU - Liontos, Michalis AU - Anastasiou, Ioannis AU - Bamias, Aristotelis AU - Dimopoulos, Meletios-Athanasios PY - 2016 TI - DNA damage, tumor mutational load and their impact on immune responses against cancer JF - Annals of Translational Medicine; Vol 4, No 14 (July 28, 2016): Annals of Translational Medicine (Immunotherapy in cancer: the clinical impact of immune response and targeting) Y2 - 2016 KW - N2 - Advances in immunotherapy have changed the therapeutic landscape in many malignancies. Immune checkpoint inhibitors have already received regulatory approval in melanomas, lung, renal and bladder carcinomas. A common feature of these neoplasms is the increased mutational load, related to a possible increase number of tumor neoantigens that are recognized by the immune system. The mechanisms that DNA damage could confer to the mutational load and the formation of neoantigens and how this could be exploited to advance our immunotherapeutic strategies is discussed in this review. UR - https://atm.amegroups.org/article/view/11106