Metformin, a biguanide derived from Galegaofficinalis (French lilac), has been used for the treatment of type 2 diabetes (T2D) for over half century. It is now the most widely prescribed anti-diabetic drug and recommended as the first line oral therapy for T2D. Metformin is generally considered as a very safe drug with favorable cost-efficacy-ratio. With regard to the safety concern of its use in gestational diabetes, Bertoldo et al. provided us an excellent summary of the current knowledge on the role of metformin in pregnant women as well as in fetal development.
This issue has included most up-to-date information regarding the conventional use of metformin as well as the potential expansion of its applications.