Focused Issue on Infective Endocarditis in the 21 Century

Posted On 2020-02-27 07:03:49



This Focused Issue on “Infective Endocarditis in the 21 Century” is edited by Dr. Francesco Nappi, Dr. Christos Mihos, and Dr. Cristiano Spadaccio.

Francesco Nappi, MD
Department of Cardiac Surgery, Centre Cardiologique du Nord de Saint-Denis, Paris, France

Dr. Francesco Nappi is a cardiothoracic surgeon currently employed at Centre Cardiologique du Nord St Denis, Paris, France. He graduated as medical doctor at the University Federico II di Napoli in 1985. He was first board-certified in general surgery and then obtained the board in cardiothoracic surgery. He was subsequently appointed as staff surgeon at the Hospital La Pitie Salpetriere where obtained subspecializations in heart transplantation, pediatric and minimally invasive surgery. He has been working for several years in the field of cardiac surgery developing surgical expertise and research interests in both clinical and biological aspects of heart disease.

In particular, his clinical research activity is focused on several themes related to functional mitral regurgitation, transcatheter aortic valve replacement, use of homografts and allogeneic tissues in valvular disease and coronary artery disease. On the basic science front his research activity is centered on the elaboration of biomechanical models describing the behavior of cardiovascular structures and on the consequent development of bioengineering solutions to improve the functionality and durability of the currently available biological substitutes. In this context, his experimental efforts, raised from several collaborative activities with other groups, led to the production of a bioresorbable scaffold to reinforce allogeneic tissues and vascular conduits for use in pediatric cardiac surgery. The results of his experimental activities also led to the filing of an international patent in this field.

Christos Mihos
Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach FL, USA

Dr. Mihos is the Director of the Echocardiography Laboratory at the Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach FL, USA, and a practicing Non-Invasive Clinical Cardiologist. He completed his Internal Medicine Residency (2009-2012) and Cardiovascular Disease Fellowship (2012-2015) at Mount Sinai Medical Center, Miami Beach FL, USA. From 2015-2017, Dr. Mihos served as an Advanced Echocardiography and Clinical Research Fellow at Massachusetts General Hospital/Harvard Medical School, Boston MA, USA. He is an Assistant Professor of Clinical Medicine at Columbia University College of Physicians & Surgeons/Division of Cardiology at Mount Sinai Heart Institute, and a Clinical Assistant Professor of Medicine in the Department of Internal Medicine, Division of Cardiology at Nova Southeastern University College of Osteopathic Medicine. He is a devoted clinical researcher, and has authored or co-authored over 160 peer-reviewed articles and abstracts.

Dr. Mihos has a keen interest in the field of valvular heart disease, and in particular mitral valve disorders. He has studied and lectured at national and international meetings on the pathophysiology, diagnosis, management, and outcomes of mitral regurgitation in patients with preserved left ventricular size and function, and in ischemic and non-ischemic cardiomyopathy. Additional areas of interest include tricuspid valve disease, hypertrophic cardiomyopathy, and the application of 2D, 3D, and strain echocardiography to the diagnosis and management of valvular heart disease.

Cristiano Spadaccio
Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, UK

Dr. Cristiano Spadaccio is a cardiothoracic surgeon at the Golden Jubilee National Hospital in Glasgow, UK and an Honorary Clinical Lecturer at the University of Glasgow in the College of Medicine Veterinary and Life Science affiliated to the Institute of Cardiovascular and Medical Sciences. He graduated as medical doctor at the University Campus Bio-Medico of Rome in 2006. He obtained and completed a postdoctoral training at the University of Pittsburgh Medical Center at the department of Cardiovascular Surgery and at the McGowan Institute for Regenerative Medicine where he was dedicated to stem cell differentiation, 3D culture using bioresorbable scaffolds and development of 3D systems for stem cells differentiation. He obtained his PhD degree at the University La Sapienza of Rome in 2009 working on tissue engineering of heart, vessels, bone and muscles. He has also been associate visiting investigator at the unit of translational medicine and research at the Doctor Negrin University Hospital, Spain where he dedicated to the in vivo application of bioresorbable scaffolds for cardiovascular translational purposes.

From the clinical point of view, Dr. Spadaccio is dedicated to aortic surgery and he is currently attending a AATS aortic fellowship in Anzhen Hospital, Beijing. He is also interested in coronary surgery, minimally invasive cardiac surgery for both the aortic and mitral valve and in transcatheter procedures.

His basic science research activity is focused on several themes related to stem cells differentiation, tissue engineering and regenerative medicine with particular attention to biofunctionalization of resorbable materials for tissue regeneration and to translational aspects of tissue engineering. A particular focus of his activity regards the application of biomaterials and drug delivery systems in routine clinical cardiovascular scenarios as replacement of large heart vessels.

His scientific and clinical activity is testified by over 120 papers published on international peer reviewed journal and presented his results in a number of international society meetings. He has applied for international grants related to his work sponsored by NIH and other institutions. He organized cooperative consortia for research projects with many research groups and serves as reviewer and editor for both clinical and biomedical journals.

Focused issue outline:

  1. Diagnosis of infective endocarditis. Methods in comparison
  2. Infective Endocarditis Remains a Challenging Problem: The echocardiographic point of view
  3. The best investigative procedure for the diagnosis of vegetation in right side endocarditis. How important is vegetation size?
  4. Interpretation of guidelines for the treatment of infective endocarditis
  5. Guidelines on Prosthetic Heart Valve Management in Infective Endocarditis: Comparison Between ACC/AHA Versus ESC Guidelines 
  6. Early Surgery versus Conventional Treatment for Infective Endocarditis: Do we have an answer?
  7. Left Size Endocarditis a New Management Framework
  8. The ideal substitute for surgical management of tricuspid valve endocarditis in the current era: A review
  9. Sharing of decision-making for infective endocarditis. Ethical and clinical implications