Focused Issue on Cancer Metastasis: Molecular Signaling and Therapeutic

Posted On 2019-09-18 02:54:58

This Focused Issue on “Cancer Metastasis: Molecular Signaling and Therapeutic” is edited by Dr. Khalid Sossey-Alaoui, PhD, from Division of Cancer Biology, MetroHealth Medical Research Center, MetroHealth System, Cleveland, Ohio, USA.

Dr. Sossey-Alaoui’s contributions to translational medical oncology, with particular emphasis on the field of breast cancer metastasis, have earned him international recognition. His multiciliary research interests have focused on the identification and characterization of genes that are involved in the development, progression and metastasis of cancer, with special emphasis on breast cancer and the ultimate goal of developing novel therapeutic strategies that specifically target and inhibit metastasis. His passion for molecular genetics resulted in the identification of the DCX gene or Doublecortin, during his first year as a Postdoctoral Fellow at the Greenwood Genetics Center in South Carolina. The DCX gene is required for neuronal migration and, therefore, for brain development and proper neuronal stratification of the cerebral cortex. Mutations in the DCX gene cause X-linked lissencephaly or smooth brain, a phenotype that is associated with severe mental retardation during early childhood development. Over the years, DCX turned out to also be associated with the aggressiveness of brain tumors, such as glioblastoma multiforme (GBM). During his tenure as Instructor at Roswell Park Cancer Institute, he was very successful in identifying several tumor suppressor genes and oncogenes and published the resulting findings in top-tier journals, such as Oncogene, Genes Chromosomes Cancer, Clinical Cancer Research and Experimental Cell Research.

Focused issue outline:

  1. Kindlin-2, the tumor microenvironment and Breast Cancer Metastasis
  2. EphA2 and cancer metastasis
  3. Metastasis recurrence and drug resistance
  4. Tumor-Derived Extracellular Vesicles and Metastasis
  5. Mammary epithelial development or Bromodomains inhibitor in TNBCs
  6. Exosomes/integrins and cancer metastasis
  7. ECO Nanoparticles for treatment of TNBCs
  8. WAVE3 and the Invasion Metastasis Cascade in TNBCs
  9. EGFR and breast cancer metastasis
  10. Therapeutic options for Cancer metastasis
  11. Cancer Stem Cell-Mediated Progression and Therapeutic Resistance
  12. Oncogenic signaling pathways and cancer metastasis
  13. Genomic Instability
  14. Mitochondrial Metabolism
  15. Cancer Stem Cells
  16. Invadosomes and metastasis
  17. Suppression of Metastasis by Regulators of Cytoskeletal and Signaling Pathways
  18. Molecular imaging of metastases
  19. Autophagy, Dormancy and metastasis
  20. Kindlin-3/Integrins and Cancer Metastasis
  21. Epithelial-Mesenchymal Transition and metastasis
  22. Use of Stapled peptides to inhibit protein-protein interaction and metastasis
  23. Cancer disparities and the metastasis burden of triple negative breast cancer