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Editorial

Secondary analysis of electronic health records in critical care medicine
Sven Van Poucke, Alberto Alexander Gayle, Milan Vukicevic
To repair or to replace: four decades in the making
Patpilai Kasinpila, Y. Joseph Woo
Editorial on “Genesis on diamonds II: contact with diamond enhances human sperm performance by 300%”
Stepan S. Batsanov, Andrei S. Batsanov
Can pancreatitis be treated by inhibiting Ca2+ signaling?
John A. Williams, David I. Yule
An interesting approach for the diagnosis of hepatic fibrosis: Wáng et al., “A combined use of intravoxel incoherent motion MRI parameters can differentiate early-stage hepatitis-b fibrotic livers from healthy livers”
Jean-Pierre Cercueil
The surgeon thunderbolts in 2016 lung cancer literature
Luca Bertolaccini, Alessandro Pardolesi, Jury Brandolini, Piergiorgio Solli
Challenges of interpreting patient reported outcomes from clinical trials
Diane L. Fairclough
Hypertension highlights during 2016
Wilbert S. Aronow
Of diamond surfaces, red light photobiomodulation and fertility: lessons from the laboratory
Raymond J. Lanzafame
Open thoracoabdominal aortic aneurysm repair in expert hands: “all roads lead to Rome”
Giacomo Murana, Jacopo Alfonsi, Luca Di Marco, Davide Pacini
Potential benefits of large database analysis
Slav Yartsev
Treatment recommendations by clinicians in stage I non-small cell lung cancer: better work-up leads to less discussion
Jo Raskin, Annelies Janssens, Jan P. Van Meerbeeck
EGFR mutation positive non-small cell lung cancer: can we identify predictors of benefit from immune checkpoint inhibitors
Ying Wang, Peter Ellis
Eravacycline for treatment of complicated intra-abdominal infections: the fire is not ignited!
Patrick M. Honore, Herbert D. Spapen
Towards a comprehensive framework for cell-free DNA analysis: lessons from TRACERx
Bryan C. Ulrich, Nicolas Guibert
Balanced crystalloids for the critically ill: knowledge on the rise but confusion still reigns!
Patrick M. Honore, Herbert D. Spapen
Reduction in dietary sodium improves blood pressure and reduces cardiovascular events and mortality
Wilbert S. Aronow
Radiotherapy treatment strategies for squamous cell carcinoma of the cervical oesophagus: moving toward better outcomes
Pierfrancesco Franco, Francesca Arcadipane, Paolo Strignano, Renato Romagnoli, Umberto Ricardi
Selecting high-risk individuals for lung cancer screening; the use of risk prediction models vs. simplified eligibility criteria
Rudolf Kaaks, Anika Hüsing, Renée T. Fortner
Treatment recommendations for stage I non-small cell lung cancer: does patient preference matter?
Helen A Powell, David R Baldwin
Increased cancer-specific mortality in individuals developing mental disorders after cancer diagnosis: biomedical factors versus psychosocial support
Siran M. Koroukian, Martha Sajatovic
Alectinib can replace crizotinib as standard first-line therapy for ALK-positive lung cancer
Takehiro Uemura, Toyoaki Hida
Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay
Jean-Pierre Routy, Vikram Mehraj
Remote home monitoring to identify and prevent diabetic foot ulceration
P. Andrew Crisologo, Lawrence A. Lavery
The role of foot collateral vessels on angiosome-oriented revascularization
César Varela, Francisco Acín, Joaquin De Haro, Ignacio Michel
River blindness goes beyond the eye: autoimmune antibodies, cross-reactive with Onchocerca volvulus antigen, detected in
Christoph Kaiser, Sébastien D. S. Pion
Fasting and engineered diets as powerful tool in the medical practice: an old approach in the new era
Concetta Panebianco, Adele Potenza, Valerio Pazienza
Lysosomal function in β-cell survival during glucolipotoxicity
Ana Batista- Gonzalez, Rajat Singh

Commentary

Integrative research agenda for diagnosis in sepsis
Katie Nolan, Ruth O’Leary, Lieuwe Bos, Ignacio Martin-Loeches

Review Article

Microscopic colitis—microbiome, barrier function and associated diseases
Saskia van Hemert, Karolina Skonieczna-Żydecka, Igor Loniewski, Piotr Szredzki, Wojciech Marlicz
Thoracic perforations—surgical techniques
Atilla Eroglu, Yener Aydin, Omer Yilmaz
What are the ethical aspects surrounding the collegial decisional process in limiting and withdrawing treatment in intensive care?
Jean-Pierre Quenot, Fiona Ecarnot, Nicolas Meunier-Beillard, Auguste Dargent, Audrey Large, Pascal Andreu, Jean-Philippe Rigaud
A few realistic questions raised by organ retrieval in the intensive care unit
Olivier Lesieur, Liliane Genteuil, Maxime Leloup
Ethical challenges involved in obtaining consent for research from patients hospitalized in the intensive care unit
Fiona Ecarnot, Jean-Pierre Quenot, Guillaume Besch, Gaël Piton
What are the ethical issues in relation to the role of the family in intensive care?
Jean-Pierre Quenot, Fiona Ecarnot, Nicolas Meunier-Beillard, Auguste Dargent, Audrey Large, Pascal Andreu, Jean-Philippe Rigaud
Establishing an evaluation mode with multiple primary outcomes based on combination of diseases and symptoms in TCM clinical trials
Jing Hu, Shuo Liu, Weihong Liu, Huina Zhang, Jing Chen, Hongcai Shang
Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy
Miren Zuazo, Maria Gato-Cañas, Noelia Llorente, María Ibañez-Vea, Hugo Arasanz, Grazyna Kochan, David Escors
Predictors of treatment failure and clinical stability in patients with community acquired pneumonia
Deirdre Morley, Antoni Torres, Catia Cillóniz, Ignacio Martin-Loeches
Overcoming resistance to BRAF inhibitors
Imanol Arozarena, Claudia Wellbrock
Peculiarities of intra-thoracic colon interposition—eso-coloplasty: indications, surgical management and outcomes
Lucile Gust, Henri De Lesquen, Ilies Bouabdallah, Geoffrey Brioude, Pascal-Alexandre Thomas, Xavier-Benoit D’journo
Tidal volume in acute respiratory distress syndrome: how best to select it
Michele Umbrello, Antonella Marino, Davide Chiumello
The combination of checkpoint immunotherapy and targeted therapy in cancer
Niki Karachaliou, Maria Gonzalez Cao, Aaron Sosa, Jordi Berenguer, Jillian Wilhelmina Paulina Bracht, Masaoki Ito, Rafael Rosell
The 8th TNM edition for lung cancer: a critical analysis
Paul E. Van Schil, Ramon Rami-Porta, Hisao Asamura
Ethical aspects of admission or non-admission to the intensive care unit
Jean-Philippe Rigaud, Mikhael Giabicani, Marion Beuzelin, Antoine Marchalot, Fiona Ecarnot, Jean-Pierre Quenot
Airway microbiome research: a modern perspective on surveillance cultures?
Damien Roux, Pouline M. van Oort, Jean-Damien Ricard, Lieuwe D. J. Bos
Molecular analysis driven video-assisted thoracic surgery resections in bilateral synchronous lung cancers: from the test tube to the operatory room
Sergio Nicola Forti Parri, Barbara Bonfanti, Alessandra Cancellieri, Dario De Biase, Rocco Trisolini, Stefania Zoboli, Luca Bertolaccini, Piergiorgio Solli, Giovanni Tallini
Case management: an up-to-date review of literature and a proposal of a county utilization
Elisa Fabbri, Maddalena De Maria, Luca Bertolaccini
Integrating surgery and genetic testing for the modern surgeon
Raul Caso, Matthew Beamer, Alexander D. Lofthus, Michael Sosin
What are the ethical questions raised by the integration of intensive care into advance care planning?
Jean-Pierre Quenot, Fiona Ecarnot, Nicolas Meunier-Beillard, Auguste Dargent, Audrey Large, Pascal Andreu, Jean-Philippe Rigaud
Predictive factors of response to immunotherapy—a review from the Spanish Melanoma Group (GEM)
Enrique Espinosa, Ivan Márquez-Rodas, Ainara Soria, Alfonso Berrocal, Jose Luis Manzano, Maria Gonzalez-Cao, Salvador Martin Algarra, On behalf of the Spanish Melanoma Group (GEM)
Digital chest tomosynthesis: the 2017 updated review of an emerging application
Arianna Ferrari, Luca Bertolaccini, Piergiorgio Solli, Paola Oriana Di Salvia, David Scaradozzi
Ground glass opacities management in the lung cancer screening era
Marcello Migliore, Mariaconcetta Fornito, Manuela Palazzolo, Alessandra Criscione, Mariapia Gangemi, Francesco Borrata, Enrica Romeo, Paolo Vigneri, Marco Nardini, Joel Dunning
Economic evaluation of different suture closure methods: barbed versus traditional interrupted sutures
Randa K. Elmallah, Anton Khlopas, Mhamad Faour, Morad Chughtai, Arthur L. Malkani, Peter M. Bonutti, Martin Roche, Steven F. Harwin, Michael A. Mont
Extracorporeal life support in preoperative and postoperative heart transplant management
Christian A. Bermudez, D. Michael McMullan
Nebulized anticoagulants in lung injury in critically ill patients—an updated systematic review of preclinical and clinical studies
Jenny Juschten, Pieter R. Tuinman, Nicole P. Juffermans, Barry Dixon, Marcel Levi, Marcus J. Schultz
New trends in antitumor vaccines in melanoma
Marcos Vasquez, Shirley Tenesaca, Pedro Berraondo
Antibiotic consumption and ventilator-associated pneumonia rates, some parallelism but some discrepancies
David Nora, Pedro Póvoa

Original Article

Midterm outcomes of titanium modular femoral necks in total hip arthroplasty
Thurial Collet, Jean-Pierre Atanasiu, Jean-Baptiste de Cussac, Kamal Oufroukhi, Hugo Bothorel, Mo Saffarini, François Badatcheff
Factors that influence blood loss and need for transfusion following total knee arthroplasty
Achilleas Boutsiadis, Ryan Jacob Reynolds, Mo Saffarini, Jean-Claude Panisset
Outcomes of a newer-generation cementless total knee arthroplasty design in patients less than 50 years of age
Michael A. Mont, Chukwuweike Gwam, Jared M. Newman, Morad Chughtai, Anton Khlopas, Prem N. Ramkumar, Steven F. Harwin
A pilot study evaluating biomarker development for drug-induced chronic eczematous eruptions of aging individuals
Erika Mae Summers, Nicholas Ray Blickenstaff, Garrett Curtis Coman, Thomas Bernd Martins, Harry Raymond Hill, Richard Dennis Sontheimer
Detection of MET amplification in gastroesophageal tumor specimens using IQFISH
Jan Trøst Jørgensen, Karsten Bork Nielsen, Jens Mollerup, Anna Jepsen, Ning Go
Calcitonin gene-related peptide: neuroendocrine communication between the pancreas, gut, and brain in regulation of blood glucose
Sayali A. Pendharkar, Monika Walia, Marie Drury, Maxim S. Petrov

Case Report

Application of 3D technology and printing for femoral derotation osteotomy: case and technical report
Nicolás Fiz, Diego Delgado, Xabier Sánchez, Pello Sánchez, Ane Miren Bilbao, Jaime Oraa, Mikel Sánchez
Myocardial bridging with left ventricular hypertrophy presenting as Wellens pattern
Ahmad Abuarqoub, Maria Naranjo, Fayez Shamoon
Surgical treatment of synchronous multiple neuroendocrine lung tumours (case series): is more always better?
Jury Brandolini, Luca Bertolaccini, Alessandro Pardolesi, Piergiorgio Solli

Meeting Report

Highlights of the season 2016–2017 by the Spanish Melanoma Group (GEM)
Ainara Soria, Jose Luis Manzano, Alfonso Berrocal, Enrique Espinosa, Ivan Marquez-Rodas, Maria Gonzalez-Cao, Salvador Martin-Algarra, On behalf of the Spanish Melanoma Group (GEM)
Report from the II melanoma translational meeting of the Spanish Melanoma Group (GEM)
Maria Gonzalez-Cao, Alfonso Berrocal, Susana Puig, Niki Karachaliou, Leticia De Matos-Arruda, Joan Seoane, David Escors, Carmen Alvarez, Jose Pedro Vaque, Aleix Prat, Claudia Wellbrock, Imanol Arozarena, Ivan Marquez-Rodas, Enrique Espinosa, Migue Angel Molina, Teresa Puertolas, Manuel Juan-Otero, Rosina Malagrida, Eloisa Jantus-Lewintre, Virtudes Soriano, Ana Arance, Jose Luis Manzano, Paul Lorigan, Thomas F. Gajewski, Rafael Rosell, On behalf of the Spanish Melanoma Group (GEM)
Infomelanoma 2020: an online digital application designed to assist health professionals for melanoma treatment
Maria González-Cao, Mar Carrasco-Calvo, Ainara Soria, Alfonso Berrocal, Ana Arance, Susana Puig, Laura Alós, Santiago Viteri, Pablo Cerezuela, Salvador Martín-Algarra

Big-data Clinical Trial Column

Nomogram for survival analysis in the presence of competing risks
Zhongheng Zhang, Ronald B. Geskus, Michael W. Kattan, Haoyang Zhang, Tongyu Liu
Development of scoring system for risk stratification in clinical medicine: a step-by-step tutorial
Zhongheng Zhang, Haoyang Zhang, Mahesh Kumar Khanal