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Editorial

Secondary analysis of electronic health records in critical care medicine
Sven Van Poucke, Alberto Alexander Gayle, Milan Vukicevic
To repair or to replace: four decades in the making
Patpilai Kasinpila, Y. Joseph Woo
Can pancreatitis be treated by inhibiting Ca2+ signaling?
John A. Williams, David I. Yule
The surgeon thunderbolts in 2016 lung cancer literature
Luca Bertolaccini, Alessandro Pardolesi, Jury Brandolini, Piergiorgio Solli
River blindness goes beyond the eye: autoimmune antibodies, cross-reactive with Onchocerca volvulus antigen, detected in
Christoph Kaiser, Sébastien D. S. Pion
Lysosomal function in β-cell survival during glucolipotoxicity
Ana Batista- Gonzalez, Rajat Singh
Drugs targeting protease-activated receptor-4 improve the antithrombotic therapeutic window
Shauna L. French, Justin R. Hamilton
Creative technology advances tissue preservation
Mandi J. Lopez
New evidence for nodding disease as an autoimmune reaction to Onchocerca volvulus
Michael J. Boivin
Sodium-glucose cotransporter 2 inhibitors and death and heart failure in type 2 diabetes
Hidekatsu Yanai
Alectinib in untreated anaplastic lymphoma kinase-positive nonsmall cell lung cancer
Anne-Marie Ruppert, Xavier Mignard, Marie Wislez
Nrf2: a promising trove for diabetic wound healing
Amruta Jindam, Veera Ganesh Yerra, Ashutosh Kumar
Editorial on “An automated smartphone-based diagnostic assay for point-of-care semen analysis”
Sarah Coleman Vij, Ashok Agarwal
Antibody-drug conjugate targeting protein tyrosine kinase 7, a receptor tyrosine kinase-like molecule involved in WNT and vascular endothelial growth factor signaling: effects on cancer stem cells, tumor microenvironment and whole-body homeostasis
Masaru Katoh
Masked hypertension
Wilbert S. Aronow
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Novel regulators of PD-L1 expression in cancer: CMTM6 and CMTM4—a new avenue to enhance the therapeutic benefits of immune checkpoint inhibitors
Denira Imamovic, Semir Vranic
Fecal microbiota transplantation as a possible treatment of irritable bowel syndrome
Anna C. Juncadella, Alan Moss
Non-vitamin K antagonist oral anticoagulant dosing in patients with atrial fibrillation and renal dysfunction
Ahsan A. Khan, Gregory Y. H. Lip
On predicting clinical response to chemoradiotherapy in esophageal squamous cell carcinoma: additional evaluation by magnetic resonance imaging may help
Ta-Chen Huang, Chih-Hung Hsu
Telomeric zinc-finger associated protein (TZAP): a new player in telomere diseases?
Benedetta Donati, Luca Valenti
Improving deep brain stimulation: timing makes all the difference
Jan Hirschmann, Alfons Schnitzler
Tissue-nonspecific alkaline phosphatase: a promising target for pseudoxanthoma elasticum therapy
András Váradi,, Krisztina Fülöp, Tamás Arányi, Flóra Szeri
Challenges of quitting smoking and lung cancer screening
Giulia Carreras, Giuseppe Gorini
The impact of thoracic endovascular aortic repair on long-term survival in type B aortic dissection
Christos D. Karkos, Ignacio Hernandez-Lahoz, Nikolaos Asaloumidis, Konstantinos O. Papazoglou
Canagliflozin lowers blood sugar, but does it also lower cardiovascular risk? Maybe not
Thomas F. Heston, Anndres H. Olson, Nicholas R. Randall
Predictors of response and resistance to checkpoint inhibitors in solid tumors
Sanjana V. Rao, Amy E. Moran, Julie N. Graff
Message from “real-world” data of transcatheter versus surgical aortic valve replacement
Tomo Ando, Luis Afonso
Unravelling the mysterious onchocerciasis-nodding syndrome link: new developments and future challenges
Angelina Kakooza-Mwesige
Always hard to absorb: youngsters suicide from childhood adversity
Jianrong Zhang
Semaglutide—the “new kid on the block” in the field of glucagonlike peptide-1 receptor agonists?
Cristian Guja, Rucsandra Dănciulescu Miulescu
Coronary artery bypass grafting versus percutaneous coronary intervention in complex coronary artery disease: looking beyond clinical end-points
Aakash Garg, Hitesh Raheja, Marc Cohen
Ezh2-dependent therapies in bladder cancer: synthetic lethality
Cristina Segovia, Jesús M. Paramio
Transfer of altered behaviour and irritable bowel syndrome with diarrhea (IBS-D) through fecal microbiota transplant in mouse model indicates need for stricter donor screening criteria
Laura J. Craven, Michael Silverman, Jeremy P. Burton
Prediction models to advance individualized resuscitation in trauma hemorrhage and acute traumatic coagulopathy (ATC): even the longest journey starts with first steps—Lao-Tzu (Chinese philosopher)
Marc Maegele
Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward
Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola
Is there a long-term survival benefit with on pump coronary artery bypass grafting?
Nicola King
The ODYSSEY DM-DYSLIPIDEMIA trial: confirming the benefits of alirocumab in diabetic mixed dyslipidemia
Paul Chan, Li Shao, Brian Tomlinson, Zhong-Min Liu
Antiangiogenic therapy and immune checkpoint blockade go hand in hand
Luis Felipe Campesato, Taha Merghoub
Switch-on the LAMP to spot Zika
Erick Mora-Cárdenas, Alessandro Marcello
Definitive chemoradiation for resectable carcinoma of the cervical esophagus: do we need more evidence?
Antoine Adenis, Guillaume Piessen, David Azria
Surrogate end points in early prostate cancer clinical states: ready for implementation?
Christos E. Kyriakopoulos, Emmanuel S. Antonarakis
Cardiovascular outcome studies with glucagon-like peptide 1 receptor agonists—what will REWIND add?
Keith C. Ferdinand, Indrajeet Mahata
Empagliflozin reduces albuminuria—a promise for better cardiorenal protection from the EMPA-REG OUTCOME trial
Rikke Borg, Frederik Persson
LAMP assay for specific detection of Asian and African lineage Zika virus: will it meet the expectations?
Yaniv Lustig, Danit Sofer, Musa Hindiyeh, Ella Mendelson

Perspective

The subtypes of microscopic colitis from a pathologist’s perspective: past, present and future
Peter Johan Heiberg Engel, Anne-Marie Kanstrup Fiehn, Lars Kristian Munck, Martin Kristensson
Liquid biopsy for ctDNA to revolutionize the care of patients with early stage lung cancers
Bob T. Li, Dennis Stephens, Jamie E. Chaft, Charles M. Rudin, David R. Jones, Valerie W. Rusch, Andreas Rimner, James M. Isbell

Commentary

Integrative research agenda for diagnosis in sepsis
Katie Nolan, Ruth O’Leary, Lieuwe Bos, Ignacio Martin-Loeches

Review Article

Microscopic colitis—microbiome, barrier function and associated diseases
Saskia van Hemert, Karolina Skonieczna-Żydecka, Igor Loniewski, Piotr Szredzki, Wojciech Marlicz
Thoracic perforations—surgical techniques
Atilla Eroglu, Yener Aydin, Omer Yilmaz
What are the ethical aspects surrounding the collegial decisional process in limiting and withdrawing treatment in intensive care?
Jean-Pierre Quenot, Fiona Ecarnot, Nicolas Meunier-Beillard, Auguste Dargent, Audrey Large, Pascal Andreu, Jean-Philippe Rigaud
A few realistic questions raised by organ retrieval in the intensive care unit
Olivier Lesieur, Liliane Genteuil, Maxime Leloup
Ethical challenges involved in obtaining consent for research from patients hospitalized in the intensive care unit
Fiona Ecarnot, Jean-Pierre Quenot, Guillaume Besch, Gaël Piton
What are the ethical issues in relation to the role of the family in intensive care?
Jean-Pierre Quenot, Fiona Ecarnot, Nicolas Meunier-Beillard, Auguste Dargent, Audrey Large, Pascal Andreu, Jean-Philippe Rigaud
Predictors of treatment failure and clinical stability in patients with community acquired pneumonia
Deirdre Morley, Antoni Torres, Catia Cillóniz, Ignacio Martin-Loeches
Peculiarities of intra-thoracic colon interposition—eso-coloplasty: indications, surgical management and outcomes
Lucile Gust, Henri De Lesquen, Ilies Bouabdallah, Geoffrey Brioude, Pascal-Alexandre Thomas, Xavier-Benoit D’journo
Tidal volume in acute respiratory distress syndrome: how best to select it
Michele Umbrello, Antonella Marino, Davide Chiumello
The 8th TNM edition for lung cancer: a critical analysis
Paul E. Van Schil, Ramon Rami-Porta, Hisao Asamura
Ethical aspects of admission or non-admission to the intensive care unit
Jean-Philippe Rigaud, Mikhael Giabicani, Marion Beuzelin, Antoine Marchalot, Fiona Ecarnot, Jean-Pierre Quenot
Airway microbiome research: a modern perspective on surveillance cultures?
Damien Roux, Pouline M. van Oort, Jean-Damien Ricard, Lieuwe D. J. Bos
What are the ethical questions raised by the integration of intensive care into advance care planning?
Jean-Pierre Quenot, Fiona Ecarnot, Nicolas Meunier-Beillard, Auguste Dargent, Audrey Large, Pascal Andreu, Jean-Philippe Rigaud
Digital chest tomosynthesis: the 2017 updated review of an emerging application
Arianna Ferrari, Luca Bertolaccini, Piergiorgio Solli, Paola Oriana Di Salvia, David Scaradozzi
Ground glass opacities management in the lung cancer screening era
Marcello Migliore, Mariaconcetta Fornito, Manuela Palazzolo, Alessandra Criscione, Mariapia Gangemi, Francesco Borrata, Enrica Monaco, Paolo Vigneri, Marco Nardini, Joel Dunning
Economic evaluation of different suture closure methods: barbed versus traditional interrupted sutures
Randa K. Elmallah, Anton Khlopas, Mhamad Faour, Morad Chughtai, Arthur L. Malkani, Peter M. Bonutti, Martin Roche, Steven F. Harwin, Michael A. Mont
Nebulized anticoagulants in lung injury in critically ill patients—an updated systematic review of preclinical and clinical studies
Jenny Juschten, Pieter R. Tuinman, Nicole P. Juffermans, Barry Dixon, Marcel Levi, Marcus J. Schultz
Antibiotic consumption and ventilator-associated pneumonia rates, some parallelism but some discrepancies
David Nora, Pedro Póvoa
Esophagectomy with gastric conduit reconstruction for benign disease: extreme but important
Wei Guo, Su Yang, Hecheng Li
Nebulised antibiotherapy: conventional versus nanotechnologybased approaches, is targeting at a nano scale a difficult subject?
Esther de Pablo, Raquel Fernández-García, María Paloma Ballesteros, Juan José Torrado, Dolores R. Serrano
Intersecting vulnerabilities in professionals and patients in intensive care
Nicolas Meunier-Beillard, Auguste Dargent, Fiona Ecarnot, Jean-Philippe Rigaud, Pascal Andreu, Audrey Large, Jean-Pierre Quenot
Cell therapy for the treatment of sepsis and acute respiratory distress syndrome
Raquel Guillamat-Prats, Marta Camprubí-Rimblas, Josep Bringué, Neus Tantinyà, Antonio Artigas
Making progress in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer by surpassing resistance: third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs)
Giannis Mountzios
Defects in innate and adaptive immunity in patients with sepsis and health care associated infection
Thomas Ryan, John D. Coakley, Ignacio Martin Loeches
What are the ethical dimensions in the profession of intensive care specialist?
Jean-Pierre Quenot, Fiona Ecarnot, Nicolas Meunier- Beillard, Auguste Dargent, Jean-Pierre Eraldi, François Bougerol, Audrey Large, Pascal Andreu, Jean-Philippe Rigaud
Outcomes following transcatheter aortic valve replacement in patients with native aortic valve regurgitation
Tamunoinemi Bob-Manuel, Siri Kadire, Mark R. Heckle, Jiajing Wang, Uzoma N. Ibebuogu
When more is not better—appropriately excluding patients from mechanical circulatory support therapy
Mannu Nayyar, Kevin Michael Donovan, Rami N. Khouzam
Relationship between hyperoxemia and ventilator associated pneumonia
Karim Jaffal, Sophie Six, Farid Zerimech, Saad Nseir
Personalized therapy based on image for esophageal or gastroesophageal junction adenocarcinoma
Kazuto Harada, Dilsa Mizrak Kaya, Anthony Lopez, Hideo Baba, Jaffer A. Ajani
A review of racial disparities in transcatheter aortic valve replacement (TAVR): accessibility, referrals and implantation
Tamunoinemi Bob-Manuel, Arindam Sharma, Amit Nanda, Devarshi Ardeshna, William Paul Skelton IV, Rami N. Khouzam
Asian-Indians: a review of coronary artery disease in this understudied cohort in the United States
Devarshi R. Ardeshna, Tamunoinemi Bob-Manuel, Amit Nanda, Arindam Sharma, William Paul Skelton Iv, Michelle Skelton, Rami Khouzam
The next generation of rapid point-of-care testing identification tools for ventilator-associated pneumonia
Guillaume Millot, Benoit Voisin, Caroline Loiez, Frédéric Wallet, Saad Nseir
Access site complications in transcutaneous aortic valve replacement: frequency, outcomes, prevention, and treatment
Samuel Latham, Tamunoinemi Bob-Manuel, Arindam Sharma, Amit Nanda, Devareshi Ardeshna, Rami Khouzam
Current therapeutic landscape for advanced gastroesophageal cancers
Anthony Lopez, Kazuto Harada, Dilsa Mizrak Kaya, Jaffer A. Ajani
The frontline of esophageal cancer treatment: questions to be asked and answered
Cheng-Che Tu, Po-Kuei Hsu
Immune checkpoint pathways in non-small cell lung cancer
Young Kwang Chae, Ayush Arya, Wade Iams, Marcello Cruz, Nisha Mohindra, Victoria Villaflor, Francis J. Giles

Original Article

Outcomes of a newer-generation cementless total knee arthroplasty design in patients less than 50 years of age
Michael A. Mont, Chukwuweike Gwam, Jared M. Newman, Morad Chughtai, Anton Khlopas, Prem N. Ramkumar, Steven F. Harwin
Detection of MET amplification in gastroesophageal tumor specimens using IQFISH
Jan Trøst Jørgensen, Karsten Bork Nielsen, Jens Mollerup, Anna Jepsen, Ning Go
Comparative effectiveness and safety of empagliflozin on cardiovascular mortality and morbidity in adults with type 2 diabetes
Wilbert S. Aronow, Tatyana A. Shamliyan
Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction
Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

Case Report

Double conduction through the atrioventricular node following acute medullary infarction: a case report
Salem A. Salem, Nadish Garg, Raed Abu Shama, Sunil Jha, Showkat Haji, Muhammed Shahreyar, Devarshi Ardeshna

Letter to the Editor

Diamonds are for men, too
Andrei P. Sommer
Radiation risk from lung cancer screening
Cristiano Rampinelli, Paolo De Marco, Massimo Bellomi

Big-data Clinical Trial Column

Rainforest plots for the presentation of patient-subgroup analysis in clinical trials
Zhongheng Zhang, Michael Kossmeier, Ulrich S. Tran, Martin Voracek, Haoyang Zhang
Comparing baseline characteristics between groups: an introduction to the CBCgrps package
Zhongheng Zhang, Alberto Alexander Gayle, Juan Wang, Haoyang Zhang, Pablo Cardinal-Fernández