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Editorial

Aortic valve replacement in young patients: should the biological prosthesis be recommended over the mechanical?
Alberto Alperi, Daniel Hernandez-Vaquero, Isaac Pascual, Rocio Diaz, Iria Silva, Ruben Alvarez-Cabo, Pablo Avanzas, Cesar Moris
The choice of heart valve prosthesis for aortic valve replacement in the young: about choices and consequences
Thierry Bove
Bioprosthetic aortic valve replacement: a telltale from the young
Athanasios Antoniou, Amer Harky, John Yap, Kulvinder Kulvinder Lall, Mohamad Bashir
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Can we exonerate GLP-1 receptor agonists from blame for adverse pancreatic events?
Conor F. Murphy, Carel W. le Roux
Translating patient related outcome measures into practice— lessons to be learnt
Waseem Majeed, Hood Thabit
Does continuous glucose monitoring during pregnancy improve glycaemic and health outcomes in women with type 1 diabetes?— what the CONCEPTT trial adds
Diane Farrar, Matthew D. Campbell
Untangling the bilateral versus single internal mammary coronary artery bypass grafting debate
Emile Voisine, Pierre Voisine
Improved outcome of bilateral compared to single internal thoracic artery grafting: patient’s selection or technical skill?
Antonio M. Calafiore, Carlo Maria De Filippo, Massimiliano Foschi, Michele Di Mauro
BPI fold-containing family a member 2 as a biomarker of acute kidney injury—close but no (clinical) cigar?
Patrick M. Honore, David De Bels, Herbert D. Spapen
The role of glucagon-like peptide-1 receptor agonists in cardiovascular disease prevention in type 2 diabetes mellitus: evidence from the most recent clinical trials
S John Weisnagel
AdDIT Editorial comment—challenges in medication treatment of renal and cardiovascular diseases and risk factors in adolescents with type 1 diabetes
Fariba Ahmadizar, Anke H. Maitland-van der Zee
Pioglitazone and cardiovascular risk in T2DM patients: is it good for all?
Muhammad Abdul-Ghani, Amin Jayyous, Nidal Asaad, Sherif Helmy, Jassim Al-Suwaidi
Low-dose aspirin for primary cardiovascular prevention in diabetic patients: the issue to believe it or not
Priscilla Lamendola, Angelo Villano, Augusto Fusco, Massimo Leggio
Aspirin and diabetes mellitus in primary prevention: the Endless Conundrum
Rubén Casado-Arroyo
Anti-diabetic agents and heart health: how to use new diabetes medications in a global strategy for the prevention of cardiovascular complications in type 2 diabetes
Carmine Gazzaruso, Adriana Coppola, Tiziana Montalcini, Colomba Falcone
Quality of life and treatment satisfaction are highly relevant patient-reported outcomes in type 2 diabetes mellitus
Didac Mauricio

Review Article

Tidal volume in acute respiratory distress syndrome: how best to select it
Michele Umbrello, Antonella Marino, Davide Chiumello
Making progress in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer by surpassing resistance: third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs)
Giannis Mountzios
Treating ALK-positive non-small cell lung cancer
Dimitrios C. Ziogas, Anna Tsiara, Georgios Tsironis, Maria Lykka, Michalis Liontos, Aristotelis Bamias, Meletios-Athanasios Dimopoulos
The emerging treatment landscape of advanced non-small cell lung cancer
Panagiota Economopoulou, Giannis Mountzios
Breakthroughs in the treatment of advanced squamous-cell NSCLC: not the neglected sibling anymore?
Georgios Tsironis, Dimitrios C. Ziogas, Anastasios Kyriazoglou, Marita Lykka, Konstantinos Koutsoukos, Aristotelis Bamias, Meletios-Athanasios Dimopoulos
Implementation of immunotherapy in the treatment of advanced non-small cell lung cancer (NSCLC)
Anna Tsiara, Michalis Liontos, Maria Kaparelou, Roubini Zakopoulou, Aristotelis Bamias, Meletios-Athanasios Dimopoulos
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer
Immune checkpoint inhibitors and radiotherapy—concept and review of current literature
Loka Thangamathesvaran, Roshni Shah, Rebeka Verma, Omar Mahmoud
Quality in upper gastrointestinal endoscopic submucosal dissection
Flaminia Purchiaroni, Guido Costamagna, Cesare Hassan
Financial toxicity and implications for cancer care in the era of molecular and immune therapies
George Tran, S. Yousuf Zafar
Novel chemotherapy regimens for advanced lung cancer: have we reached a plateau?
Panagiotis Baxevanos, Giannis Mountzios
Chromatin remodeling defects in pediatric brain tumors
Alexia Klonou, Danai Spiliotakopoulou, Marios S. Themistocleous, Christina Piperi, Athanasios G. Papavassiliou
Advances on systemic treatment for lung neuroendocrine neoplasms
Nikolaos Tsoukalas, Panagiotis Baxevanos, Eleni Aravantinou-Fatorou, Maria Tolia, Michail Galanopoulos, Konstantinos Tsapakidis, George Kyrgias, Christos Toumpanakis, Gregory Kaltsas
Advanced small cell lung cancer (SCLC): new challenges and new expectations
Nikolaos Tsoukalas, Eleni Aravantinou-Fatorou, Panagiotis Baxevanos, Maria Tolia, Konstantinos Tsapakidis, Michail Galanopoulos, Michail Liontos, George Kyrgias
Molecular mechanisms of mechanotransduction in psoriasis
Lina S. Malakou, Antonios N. Gargalionis, Christina Piperi, Evangelia Papadavid, Athanasios G. Papavassiliou, Efthimia K. Basdra
Beyond EGFR and ALK: targeting rare mutations in advanced non-small cell lung cancer
Stavros Gkolfinopoulos, Giannis Mountzios
Quality in endoscopy training—the endoscopic retrograde cholangiopancreatography case
Ivan Jovanovic, Klaus Mönkemüller
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Microglial priming in Alzheimer’s disease
Jun-Wei Li, Yu Zong, Xi-Peng Cao, Lin Tan, Lan Tan

Original Article

Alcohol use disorders before and after bariatric surgery: a systematic review and meta-analysis
Hamza Azam, Sara Shahrestani, Kevin Phan
A technique of hand digit reconstruction using scarred and deformed donor segments
Nikolay M. Alexandrov, Michail G. Volovik, Denis V. Kiselev, Sergey V. Petrov
Monitoring of colonoscopy quality indicators in an academic endoscopy facility reveals adherence to international recommendations
Stefanos Karamaroudis, Aliki Stamou, Stamatia C. Vorri, Paraskevas Gkolfakis, Vasilios Papadopoulos, Georgios Tziatzios, Aikaterini Karagouni, Panagiota Katsouli, George D. Dimitriadis, Konstantinos Triantafyllou
Effects of atypical antipsychotic drugs on QT interval in patients with mental disorders
Wilbert S. Aronow, Tatyana A. Shamliyan
Rosiglitazone inhibits PM2.5-induced cytotoxicity in human lung epithelial A549 cells
Xian-Juan Pu, Jin Li, Qiu-Lian Zhou, Wen Pan, Yong-Qin Li, Yuhui Zhang, Jinhua Wang, Zheng Jiao
The expression of KATP channel subunits in alpha-synucleintransfected MES23.5 cells
Shuai-Shuai Han, Qian Jiao, Ming-Xia Bi, Xi-Xun Du, Hong Jiang
The practical benefit of Phadiatop test as the first-line in vitro allergen-specific immunoglobulin E (sIgE) screening of aeroallergens among Chinese asthmatics: a validation study
Guangqiao Zeng, Haisheng Hu, Peiyan Zheng, Ge Wu, Nili Wei, Xueqing Liang, Baoqing Sun, Xiaowen Zhang
Traditional Chinese medicine Qiliqiangxin attenuates phenylephrine-induced cardiac hypertrophy via upregulating PPARγ and PGC-1α
Rong-Rong Gao, Xiao-Dong Wu, Hui-Min Jiang, Yu-Jiao Zhu, Yan-Li Zhou, Hai-Feng Zhang, Wen-Ming Yao, Yong-Qin Li, Xin-Li Li

Case Report

Abnormal chest X-ray leading to diagnosis of partial anomalous pulmonary venous connection
Zahava Farkas, Abbas Haidry, Srikanth Yandrapalli, Marc Lim, Diwakar Jain, Wilbert S. Aronow

Surgical Technique

Resection of esophageal diverticulum through uniportal video-assisted thoracoscopic surgery
Alfonso Fiorelli, Anna Cecilia Izzo, Ettore Arrigo, Francesco Sgalambro, Maria Antonietta Lepore, Massimo Cajozzo, Sergio Castorina, Attilio Ignazio Lo Monte, Mario Santini, Francesco Paolo Caroni