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Editorial

Hyperphosphatemia: a novel risk factor for mortality in chronic kidney disease
Mario Cozzolino, Paola Ciceri, Andrea Galassi
Relationship between microaspiration of gastric contents and ventilator-associated pneumonia
Anahita Rouzé, Emmanuelle Jaillette, Saad Nseir
Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?
Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd
Early osteoarthritis of the knee: from conservative to surgical management
Pier Francesco Indelli, Michele Giuntoli
“A rose by any other name”: does defining extreme phenotypes add to the management of multiple sclerosis?
Evan A. Jolliffe, Brian G. Weinshenker
Trends in ACL reconstruction: an “individualized approach”
Philippe Landreau
Translational animal models for endometriosis research: a long and windy road
Antonio Simone Laganà, Simone Garzon, Massimo Franchi, Jvan Casarin, Giuseppe Gullo, Fabio Ghezzi
Calcium and/or vitamin D supplementation: could they affect your risks of colorectal cancer development or progression?
Lynnette R. Ferguson
Search for a reliable biomarker of acute kidney injury: to the heart of the problem
Luca Di Lullo, Biagio Raffaele Di Iorio, Claudio Ronco, Antonio Bellasi
The new basal insulin analog glargine U-300 enables flexible injection schedule
Uru Nezu Osada, Yasuo Terauchi
HLA-B*58:01 is not the only risk factor associated with allopurinol-induced severe cutaneous adverse drug reactions
Margarida Gonçalo
Molecular imaging in large vessel vasculitis has come to stay
Isabel Martínez-Rodríguez, Miguel A. González-Gay, Diana Prieto-Peña, Ignacio Banzo
TBX20 and the PROK2-PROKR1 pathway—new kid on the block in angiogenesis research
Michael Lichtenauer, Christian Jung
Tumor inactivation of E-cadherin: a new tool for breast cancer treatment?
Giovanni Corso, Bernardo Bonanni, Paolo Veronesi
Durability of mitral valve repair for degenerative mitral regurgitation: is it gold all that glitters?
Antonio M. Calafiore, Antonio Totaro, Massimiliano Foschi, Michele Di Mauro
Anticoagulation after mechanical aortic valve implantation: is it time to act after PROACT?
Mevlüt Çelik, Andras P. Durko, Stuart J. Head
Self-condensation culture for vascularized organoid
Shoichiro Sumi
The benefits of youth sports participation should outweigh the risks
Carola F. van Eck, Freddie H. Fu
Is B-type natriuretic peptide (BNP) similarly associated with mortality in patients with and without heart failure?
Norihide Fukushima
Extracorporeal membrane oxygenation in acute respiratory distress syndrome: why is the EOLIA trial important?
Nicolas Persico, Christophe Guervilly, Antoine Roch, Laurent Papazian
Osteochondral lesions of the talus: are we ready for metal?
Riccardo D’Ambrosi, Federico Giuseppe Usuelli
Evaluation of kinematic changes of intervertebral discs and the space available for the cord
Federico Canavese, Yann Philippe Charles, Alain Dimeglio
Adult mesenchymal stem cells for the treatment in patients with rotator cuff disease: present and future direction
Dong Rak Kwon, Gi-Young Park
Local modalities for inoperable hepatocellular carcinoma: radiofrequency ablation versus stereotactic body radiotherapy
Sun Hyun Bae, Hee Chul Park
Fusion heals the broken-hearted
Daniel A. Zuppo, Michael Tsang
Cardiac troponin I—more than a biomarker for myocardial ischemia?
Li Ni, Xander H. T. Wehrens
Genetics in systemic lupus erythematosus: entering the borough of cardiovascular risk
Giuseppe A. Ramirez
LXRs are finally being adequately targeted in atherosclerosis
Julio Buñay, Silvère Baron, Jean-Marc A. Lobaccaro
Immunoscore—has it scored for colon cancer precision medicine?
Robert N. Jorissen, Anuratha Sakthianandeswaren, Oliver M. Sieber
Surrogate study endpoints in the era of cancer immunotherapy
Tsuyoshi Hamada, Keisuke Kosumi, Yousuke Nakai, Kazuhiko Koike
The hemodynamic effects of norepinephrine: far more than an increase in blood pressure!
Pierre Foulon, Daniel De Backer
Ifi204/p204, a new piece in the sepsis puzzle
Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay
Validating innovations to improve recovery after heart surgery
Ali Fatehi Hassanabad, Paul W. M. Fedak
High-density lipoprotein lifts the “dark web” cast by neutrophils
Diego Lucero, Edward B. Neufeld, Alan T. Remaley
EBOV-RNA test with RT-PCR in ocular fluids of Ebola survivors can help to safely perform cataract surgery
Leopoldo Spadea, Nicola Iozzo
Reforming disease classification system—are we there yet?
Mikhail G. Dozmorov
The status of medical expulsive therapy in the age of evidence-based medicine
Julian Veser, Christian Seitz
Treatment of induction in resectable NSCLC with chemotherapy, followed by surgery and erlotinib
Fernando Franco, Mariano Provencio
Silent myocardial infarction and risk of heart failure
Timir K. Paul, Debabrata Mukherjee
Endoscopic saphenous vein harvesting and surgical site infections after coronary artery bypass surgery
Antonio Salsano, Giovanni Mariscalco, Francesco Santini
The answer is cilia, whatever the question may be!
Andrew Bush, Claire Hogg
Treating atherosclerosis: targeting risk factors should not be the only option
Montserrat Fibla, Anna Hernández-Aguilera, Jordi Camps, Javier A. Menendez, Jorge Joven
Screening of three-dimensional spheroids of ovarian cancer: identification of novel therapeutics targeting stemness and chemoresistance
Neveen Said
Simulation modeling for clinical trials evaluating radiotherapy omission in low-risk early breast cancer
Pierfrancesco Franco, Umberto Ricardi
Host-pathogen interactions in typhoid fever: the model is the message
Verónica Urdaneta, Josep Casadesús
Ebola virus and persistent chronic infection: when does replication cease?
John V. Forrester
Re-biopsy in lupus nephritis
Hans-Joachim Anders
The fecal microbiome directly drives immune activation in HIV infection
Camilla Tincati, Giuseppe Ancona, Giulia Marchetti
Pacific Rim redux: lorlatinib, the ultimate Jaeger?
Viola W. Zhu, Sai-Hong Ignatius Ou
We should not avoid diclofenac in the treatment of spondyloarthritis
Gerhard Zingler, Thomas Herdegen
Neuropathic pain models and outcome measures: a dual translational challenge
Robert D. E. Sewell
Targeting selected extracellular matrix components to attenuate cardiac fibrosis
Simranjit S. Pattar, Ali Fatehi Hassanabad, Paul W. M. Fedak
Progressive nature of myocardial fibrosis in pediatric hypertrophic cardiomyopathy: from mutation carrier to myocardial fibrosis
Hong-Mi Choi, Hyung-Kwan Kim
Non-invasive assessment of tumor PD-L1 status with circulating tumor cells
Bryan C. Ulrich, Nicolas Guibert
Cardiovascular risk prediction in older adults with the use of biomarkers
Alexandros Briasoulis, Rabea Asleh
Risk of peripheral artery disease in human immunodeficiency virus infected individuals
Kevin Belgrave, Kashif Shaikh, Matthew J. Budoff
Standardising measures in pediatric rheumatology: the experience of the international consensus dataset for juvenile dermatomyositis
Giovanni Filocamo
Issues in implementing lung cancer screening in United States and Europe
Giuseppe Gorini, Giulia Carreras
Discovering the genetic contribution to cardiovascular diseases in patients affected by autoimmune diseases
Cinzia Ciccacci
MK-2206 window of opportunity study in breast cancer
Argun Akcakanat, Funda Meric-Bernstam
New highlight in breast cancer development: the key role of hepcidin and iron metabolism
Manuel Scimeca, Elena Bonanno
Cerebrovascular contribution to dementia development after traumatic brain injury: promises and problems
Lyndsey Collins-Praino, Frances Corrigan
Radiologic features of small pulmonary nodules detected in initially negative screening CT examinations: a step towards personalized screening strategies?
Gorka Bastarrika, Juan Pablo de-Torres, Javier J. Zulueta
The different path of T790M-positive EGFR-mutant lung cancer
Shinkyo Yoon, Chang Min Choi, Jae Cheol Lee
The risk factors for brain metastases in patients with non-small cell lung cancer
Jun Hyeok Lim, Sang-Won Um

Review Article

Is intra-abdominal hypertension a risk factor for ventilatorassociated pneumonia?
Eleni Papakrivou, Eustratios Manoulakas, Epaminondas Zakynthinos, Demosthenes Makris
Are tracheal surveillance cultures useful in the intensive care unit?
Sandrine Dray, Benjamin Coiffard, Nicolas Persico, Laurent Papazian, Sami Hraiech
Ventilator-associated pneumonia related to ESBL-producing gram negative bacilli
Benoit Pilmis, Jean-Ralph Zahar
“The multimodal approach for ventilator-associated pneumonia prevention”—requirements for nationwide implementation
Francisco Álvarez-Lerma, M. Sánchez-García, Task Force of Experts for Project “Zero

Original Article

Determining association of rho kinase 1 gene polymorphisms with risk of Alzheimer’s disease: a multicenter pilot study
Ying Gao, Xia Li, Xiao-Hong Liu, Qian-Hua Zhao, Xiang-Qian Che, Qi-Hao Guo, Ru-Jing Ren, Gang Wang
Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia
Raquel Almansa, Leonor Nogales, Marta Martín-Fernández, Montse Batlle, Esther Villareal, Lucia Rico, Alicia Ortega, Guillermo López-Campos, David Andaluz-Ojeda, Paula Ramírez, Lorenzo Socias, Luis Tamayo, Jordi Vallés, Jesús F. Bermejo-Martín, Ignacio Martín-Loeches
Overview the effect of statin therapy on dementia risk, cognitive changes and its pathologic change: a systematic review and meta-analysis
Xi-Chen Zhu, Wen-Zhuo Dai, Tao Ma
Long-term effects of acupuncture for chronic prostatitis/chronic pelvic pain syndrome: systematic review and single-arm meta-analyses
Zongshi Qin, Jiani Wu, Chang Xu, Xiaopu Sang, Xiao Li, Guangrui Huang, Zhishun Liu
Deep neural networks could differentiate Bethesda class III versus class IV/V/VI
Yi Zhu, Qiang Sang, Shijun Jia, Ying Wang, Timothy Deyer
ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia
Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism
Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Detecting insertion, substitution, and deletion errors in radiology reports using neural sequence-to-sequence models
John Zech, Jessica Forde, Joseph Titano, Deepak Kaji, Anthony Costa, Eric Karl Oermann
Not all primary total hip arthroplasties are equal—so is there a difference in reimbursement?
Nipun Sodhi, Sarah E. Dalton, Luke J. Garbarino, Peter A. Gold, Nicolas S. Piuzzi, Jared M. Newman, Anton Khlopas, Assem A. Sultan, Morad Chughtai, Michael A. Mont
Machine learning for semiautomated classification of glioblastoma, brain metastasis and central nervous system lymphoma using magnetic resonance advanced imaging
Nathaniel C. Swinburne, Javin Schefflein, Yu Sakai, Eric K. Oermann, Joseph J. Titano, Iris Chen, Sayedhedayatollah Tadayon, Amit Aggarwal, Amish Doshi, Kambiz Nael
Patient satisfaction and outcomes of static progressive stretch bracing: a 10-year prospective analysis
Nipun Sodhi, Benjamin Yao, Hiba K. Anis, Anton Khlopas, Assem A. Sultan, Jared M. Newman, Michael A. Mont
Effect of erlotinib plus bevacizumab on brain metastases in patients with non-small cell lung cancer
Yasuhiro Chikaishi, Masatoshi Kanayama, Akihiro Taira, Yusuke Nabe, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Soichi Oka, Ayako Hirai, Koji Kuroda, Naoko Imanishi, Yoshinobu Ichiki, Fumihiro Tanaka
A real-world study on adverse drug reactions to Xuebijing injection: hospital intensive monitoring based on 93 hospitals (31,913 cases)
Rui Zheng, Hui Wang, Zhi Liu, Xiaohui Wang, Jing Li, Xiang Lei, Yilin Fan, Si Liu, Zhiqiao Feng, Hongcai Shang
Sole causal therapy worsens outcome as compared to no therapy and combined causal and goal-directed supportive therapy in ovine septic shock
Tim-Gerald Kampmeier, Michael Hessler, Philip Helge Arnemann, Martin Westphal, Laura Mareen Seidel, Andrea Morelli, Hugo Van Aken, Sebastian Rehberg, Christian Ertmer
Low prevalence of rheumatoid arthritis among patients with pre-existing type 2 diabetes mellitus
Anastasios Tentolouris, Anastasia Thanopoulou, Nikolaos Tentolouris, Ioanna Eleftheriadou, Christina Voulgari, Alexandros Andrianakos, Petros P. Sfikakis
The addition of 3D printed models to enhance the teaching and learning of bone spatial anatomy and fractures for undergraduate students: a randomized controlled study
Ai-Min Wu, Kai Wang, Jian-Shun Wang, Chun-Hui Chen, Xin-Dong Yang, Wen-Fei Ni, Yue-Zheng Hu
Surgical antimicrobial prophylaxis in intensive care unit (ICU) patients: a preliminary, observational, retrospective study
Gary Duclos, Bruno Pastene, Fanny Depeyre, Zoé Meresse, Nadim Cassir, Ignacio Martin-Loeches, Sharon Einav, Laurent Zieleskiewicz, Marc Leone

Case Report

Use of an offset head center acetabular shell in difficult primary total hip arthroplasties
Andrew J. Wassef, Anton Khlopas, Nipun Sodhi, Assem A. Sultan, Nicolas S. Piuzzi, Morad Chughtai, Kim L. Stearns, Robert Molloy, Michael A. Mont