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Big-data Clinical Trial Column

Propensity score analysis for time-dependent exposure
Zhongheng Zhang, Xiuyang Li, Xiao Wu, Huixian Qiu, Hongying Shi, written on behalf of AME Big-Data Clinical Trial Collaborative Group

Case Report

Rare paradoxical adverse event in Crohn’s disease: a case report
Marina Okoshi, Hiroki Sato, Terasu Honma, Shuji Terai
Localized bullous pemphigoid: a case report
Yiman Wang, Xuming Mao, Yangchun Liu, Li Li


A new peg-filgrastim biosimilar, mecapegfilgrastim for primary prophylaxis of chemotherapy-related neutropenia is now available
Umberto Tirelli, Antonino Carbone, Raffaele Di Francia, Massimiliano Berretta
TSPAN8 and distant metastasis of nasopharyngeal carcinoma cells
Changqing Xie, Nicole A. McGrath
Real-life clinical data mining: generating hypotheses for evidence-based medicine
Jean-Emmanuel Bibault
Joint forces for making clinical prediction models contribute to science
Junfeng Wang, Yue Li
Predictive analytics in the era of big data: opportunities and challenges
Zhongheng Zhang
Symptomatic late-onset hypogonadism but normal total testosterone: the importance of testosterone annual decrease velocity
Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Laura M. Mongioì, Ylenia Duca, Laura Cimino, Filippo Giacone, Antonio Aversa
Prolonged follow-up of colorectal cancer patients after 5 years: to follow or not to follow, that is the question (and how)!
Raul Caso, Anne Fabrizio, Michael Sosin
Minimally invasive mitral valve surgery to maximally benefit patients—what is the key to success today and tomorrow?
Moritz C. Wyler von Ballmoos
Clinical prediction model construction and evaluation: a challenge for clinical researchers
Qiu-Yan Han, Zhi-De Hu
Can transrectal ultrasound-guided core needle biopsy serve as an accurate diagnostic tool for rectal lesions?
Dong Hoon Baek, Gwang Ha Kim
Clinical prediction models: evaluation matters
Hong-Qiu Gu, Chelsea Liu
Combining old and new strategies for colorectal cancer screening
Elisa Danese, Martina Montagnana, Giuseppe Lippi
Overview of clinical prediction models
Lingxiao Chen
Mitochondrial solar sensitivity: evolutionary and biomedical implications
Andrei P. Sommer
Statistical methods and models in the analysis of time to event data
Minjung Lee, Junhee Han
Comparison between muscle-preserving selective laminectomy and laminoplasty for multilevel cervical spondylotic myelopathy
Satoshi Nori, Tateru Shiraishi, Ryoma Aoyama
Maintaining anorectal function in patients with rectal cancer using biofeedback training
Andrea M. Stringer
Necessity of guidelines for publication of patient-derived cancer models
Tadashi Kondo
Can human placental extract help patients with osteoarthritis?
Nequesha S. Mohamed, Wayne A. Wilkie, Ethan A. Remily, Ronald E. Delanois
Mind body medicine: a tangible link between the gut and the brain
Luis Vitetta
Models and prediction, how and what?
Yujing Xie, Zhangsheng Yu
Targeting the mitogen-activated protein kinase-mediated vascular smooth muscle cell remodeling by angiotensin II
Masanori Yoshizumi, Yoji Kyotani, Jing Zhao, Kiichi Nakahira
How to use statistical models and methods for clinical prediction
Giuliana Cortese
A role for Follistatin-like protein 1 (FSTL1) in colorectal cancer
Ioannis A. Voutsadakis
Role of echocardiography in sepsis and septic shock
Saraschandra Vallabhajosyula, Abdelrahman M. Ahmed, Pranathi R. Sundaragiri
Structural heart disease: the revolution
Daniel Hernandez-Vaquero
Human placental extract: the feasibility of translation from basic science into clinical practice
Ahmed K. Emara, Hiba Anis, Nicolas S. Piuzzi
MLKL-dependent epithelial-to-mesenchymal transition in nasopharyngeal carcinoma: a novel finding and avenues for future research
Tristan Tham
A nomogram with enhanced function facilitated by nomogramEx and nomogramFormula
Guoshu Bi, Runmei Li, Jiaqi Liang, Zhengyang Hu, Cheng Zhan
The power of clinical data empowered by clinical prediction model: an R tutorial
Lutao Dai, Dan Yang, Haipeng Shen
Bariatric surgery focused issue
Muhammed Ashraf Memon
The efficacy of polyp detection and tumor characterization of blue laser imaging, blue light imaging, and linked color imaging with light-emitted diode (LED) and LASER endoscope
Naohisa Yoshida, Osamu Dohi, Ken Inoue, Yoshito Itoh

Editorial Commentary

Application of novel nanotechnologies in asthma
Adriana Lopes da Silva, Luisa Andrade Silva, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco, Marcelo Marcos Morales
Predicting fluid responsiveness with the passive leg raising test: don’t be fooled by intra-abdominal hypertension!
Andrea Minini, Paul Abraham, Manu L. N. G. Malbrain
The passive leg raising under pressure: focus on the impact of intra-abdominal hypertension
Victor Beaucoté, Guillaume Geri, Antoine Vieillard-Baron
Periprocedural anticoagulation in non-ST-segment elevation acute coronary syndrome: time to reassess?
Rishi Chandiramani, Davide Cao, Roxana Mehran
Impact of renal impairment on light chain amyloidosis outcomes after autologous hematopoietic stem cell transplantation
Samer A. Srour, Muzaffar H. Qazilbash
Correlation between corticosteroid injections and surgical site infections in shoulder arthroscopy
Riccardo Compagnoni, Pietro Randelli
Unicompartmental knee arthroplasty over total knee arthroplasty: a more cost-effective strategy for treating medial compartment arthritis
Samuel W. Carlson, Rafael J. Sierra
Cost of cardiovascular disease prevention: towards economic evaluations in prevention programs
João Vasco Santos, Désirée Vandenberghe, Mariana Lobo, Alberto Freitas
Microcirculation and mean arterial pressure: friends or foes?
Olfa Hamzaoui, Rui Shi
The recent failure of the PROMESA clinical trial for multiple system atrophy raises the question—are polyphenols a viable therapeutic option against proteinopathies?
Gal Bitan
The Chinese experience with anti-NMDAR encephalitis
Virginie Desestret
FLT3-IRAK dual targeting: an exciting new therapeutic option guided by adaptive activation of immune response pathways
Cara A. Rabik, Jiawan Wang, Christine A. Pratilas
Keynote 42: Pembrolizumab, PD-L1, and where to draw the line
James Isaacs, Jeffrey Clarke, Neal Ready
Beyond finding druggable targets and tumor mutational burden: to measure heterogeneity by ctDNA
Zhichao Liu, Jianxing He, Wenhua Liang
When data interpretation should not rely on the magnitude of P values: the example of ANDROMEDA SHOCK trial
Francesco Corradi, Guido Tavazzi, Gregorio Santori, Francesco Forfori
To combine or not to combine: anti-vascular endothelial growth factor therapies in EGFR mutation positive non-small cell lung cancer
Hidehito Horinouchi
Medial femorotibial osteoarthritis of the knee: total or partial knee replacement?
Jean-Noel A. Argenson, Christophe Jacquet, Matthieu Ollivier
Addressing the challenge to identify the role played by lifestyle factors in dementia
Tasnime Akbaraly
The Bayesian approach: may we learn a lesson from the ANDROMEDA-SHOCK trial?
Federico Franchi, Cesare Biuzzi, Emanuele Detti, Gabriele Cevenini, Sabino Scolletta
Interpretation or misinterpretation of clinical trials on septic shock: about the ANDROMEDA-SHOCK trial
François Dépret, Maxime Coutrot
Rotator cuff muscle stem cells: the double-edged sword in the skeletal muscle
Yong-Soo Lee, Ja-Yeon Kim, Seok Won Chung

Letter to the Editor

Von Hippel-Lindau: implications in development and disease—response
Kasey R. Cargill, Sunder Sims-Lucas
Platelet-derived HMGB1: critical mediator of SARs related to transfusion
Fabrice Cognasse, Caroline Sut, Hind Hamzeh-Cognasse, Olivier Garraud
Renal double negative T cells: increasing importance in health and disease
Mohanraj Sadasivam, Sanjeev Noel, Hamid Rabb, Abdel Rahim A. Hamad
Pan-cancer analysis of KEAP1 mutations as biomarkers for immunotherapy outcomes
Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Caicun Zhou, Tao Jiang
Translating artificial intelligence into clinical practice
Duoru Lin, Haotian Lin
Below safety limits, every unit of glomerular filtration rate counts—reply letter
Carlotta Palumbo, Alessandro Antonelli
Cumulative antibiotic use significantly decreases efficacy of checkpoint inhibitors in patients with advanced cancer—reply to the editors
Nadina Tinsley, Donna M. Graham, Natalie Cook
A novel intrauterine stent for prevention of intrauterine adhesions
Huan Huang, Bin Xu, Chunxia Cheng, Dabao Xu
Why acute kidney injury during partial nephrectomy matters
Carlo A. Bravi, Andrew Vickers
Top-down proteomics—a near-future technique for clinical diagnosis?
Lidong He, Alan L. Rockwood, Archana M. Agarwal, Lissa C. Anderson, Chad R. Weisbrod, Christopher L. Hendrickson, Alan G. Marshall
ProBNP processing is decreased by obesity in patients with heart failure
Lynley K. Lewis, Sara D. Raudsepp, Tim C. R. Prickett, Tim G. Yandle, Chris J. Pemberton, A. Mark Richards
Prophylaxis of breast cancer chemotherapy for bone marrow toxicity: more individualized and safer
Fengrui Xu, Zefei Jiang
Optimized clinical randomized controlled trials designed for biomarker-guided antibiotics stewardship
Wensen Chen, Kai Zhang, Yun Liu
Circular RNAs as non-invasive urinary biomarker of kidney diseases
Malte Kölling, Johan M. Lorenzen
The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation
Katherine J. Donohue, Matthew S. Gentry, Ramon C. Sun
The role of CT for Covid-19 patient’s management remains poorly defined
Yi Xiang J. Wang, Wei-Hong Liu, Mo Yang, Wei Chen
CT imaging of coronavirus disease 2019 (COVID-19): from the qualitative to quantitative
Xiaolong Qi, Junqiang Lei, Qian Yu, Yarong Xi, Yuancheng Wang, Shenghong Ju

Meet the Professor

Prof. Leif Rogers: the recent advances in implant breast reconstruction and fat grafting
Karina Yang, Angelia Zhou
Prof. Helen Feltovich: today it’s 5G, tomorrow it’s 100G, who knows what can happen?
Jessie Bu, Angelia Zhou
Ren Zhao: no standard answer to be a doctor
Siying Yan, Chen Gao
Xiaohong Fan: breaking up “routine practices”
Siying Yan

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis
Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont
Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach
Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks
Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?
Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani
Net benefit of routine urine parameters for urinary tract infection screening: a decision curve analysis
Yan-Qiu Han, Lei Zhang, Jun-Rui Wang, Shang-Cheng Xu, Zhi-De Hu
An artificial intelligent platform for live cell identification and the detection of cross-contamination
Ruixin Wang, Dongni Wang, Dekai Kang, Xusen Guo, Chong Guo, Meimei Dongye, Yi Zhu, Chuan Chen, Xiayin Zhang, Erping Long, Xiaohang Wu, Zhenzhen Liu, Duoru Lin, Jinghui Wang, Kai Huang, Haotian Lin
Translational aspects of body image research for obesity-related quality of life and weight loss maintenance post-bariatric surgery
Marie L. Caltabiano
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry combined with UF-5000i urine flow cytometry to directly identify pathogens in clinical urine specimens within 1 hour
Chuang Sun, Xiao Zhang, Jingqiao Wang, Chen Cheng, Haiquan Kang, Bing Gu, Ping Ma
Logistic regression analyses of factors affecting fertility of intrauterine adhesions patients
Xingping Zhao, Yunzhi Liu, Aiqian Zhang, Bingsi Gao, Qing Feng, Huan Huang, Xiuting Zhu, Xin Sun, Dabao Xu
Obstetrical outcome in the third trimester after hysteroscopic adhesiolysis
Qing Feng, Bingsi Gao, Huan Huang, Jeffrey Je-Chuen Woo, Lingxiao Zou, Xingping Zhao, Chunxia Cheng, Dabao Xu
Study on the correlation among dysbacteriosis, imbalance of cytokine and the formation of intrauterine adhesion
Xingping Zhao, Qun Zhao, Xiuting Zhu, Huan Huang, Xing Wan, Rui Guo, Yanqiu Zhao, Dan Chen, Dabao Xu
Cold scissors ploughing technique in hysteroscopic adhesiolysis: a comparative study
Xingping Zhao, Aiqian Zhang, Bingsi Gao, Burjoo Arvind, Huan Huang, Dabao Xu
Building radiation-resistant model in triple-negative breast cancer to screen radioresistance-related molecular markers
Zhi-Rui Zhou, Xuan-Yi Wang, Xiao-Li Yu, Xin Mei, Xing-Xing Chen, Qun-Chao Hu, Zhao-Zhi Yang, Xiao-Mao Guo
Artificial intelligence-tutoring problem-based learning in ophthalmology clerkship
Dongxuan Wu, Yifan Xiang, Xiaohang Wu, Tongyong Yu, Xiucheng Huang, Yuxian Zou, Zhenzhen Liu, Haotian Lin
Automatic identification of myopia based on ocular appearance images using deep learning
Yahan Yang, Ruiyang Li, Duoru Lin, Xiayin Zhang, Wangting Li, Jinghui Wang, Chong Guo, Jianyin Li, Chuan Chen, Yi Zhu, Lanqin Zhao, Haotian Lin
The factors contributing to cognitive dysfunction in type 2 diabetic patients
San-Shan Xia, Wen-Lin Xia, Jiao-Jiao Huang, Hua-Jie Zou, Jing Tao, Yan Yang
Association between genetic risk scores and risk of narcolepsy: a case-control study
Hui Ouyang, Fang Han, Zechen Zhou, Qiwen Zheng, Yangyang Wang, Jun Zhang
Web-based study on Chinese dermatologists’ attitudes towards artificial intelligence
Changbing Shen, Chengxu Li, Feng Xu, Ziyi Wang, Xue Shen, Jing Gao, Randy Ko, Yan Jing, Xiaofeng Tang, Ruixing Yu, Junhu Guo, Feng Xu, Rusong Meng, Yong Cui
Growth hormone promotes human endometrial glandular cells proliferation and motion through the GHR-STAT3/5 pathway
Qing Feng, Bingsi Gao, Huan Huang, Lingxiao Zou, Xingping Zhao, Xiuting Zhu, Dabao Xu
Research of the potential biomarkers in vaginal microbiome for persistent high-risk human papillomavirus infection
Xiaopei Chao, Tingting Sun, Shu Wang, Xianjie Tan, Qingbo Fan, Honghui Shi, Lan Zhu, Jinghe Lang
Class A1 scavenger receptors mediated macrophages in impaired intestinal barrier of inflammatory bowel disease
Chenxi Xie, Yanyun Fan, Yinshi Huang, Shuangting Wu, Haimei Xu, Lupeng Liu, Yiqun Hu, Qingwen Huang, Huaxiu Shi, Lin Wang, Hongzhi Xu, Jingling Su, Jianlin Ren
The predictive value of baseline hepatic venous pressure gradient for variceal rebleeding in cirrhotic patients receiving secondary prevention
Chuan Liu, Yanna Liu, Ruoyang Shao, Sining Wang, Guangchuan Wang, Lifen Wang, Mingyan Zhang, Jinlin Hou, Chunqing Zhang, Xiaolong Qi
Prognosis and risk factors for the development of pulmonary metastases after preoperative chemoradiotherapy and radical resection in patients with locally advanced rectal cancer
Weihao Li, Jianhong Peng, Cong Li, Lifang Yuan, Wenhua Fan, Zhizhong Pan, Xiaojun Wu, Junzhong Lin
Initial anticoagulation experience with standard-dose rivaroxaban after Watchman left atrial appendage occlusion
Zhi-Chun Gu, Zhi-Qing Qiao, Zi-Yong Hao, Zheng Li, Li-Sheng Jiang, Heng Ge, Ben He, Jun Pu
Preoperative prediction of hepatocellular carcinoma with highly aggressive characteristics using quantitative parameters derived from hepatobiliary phase MR images
Zheng Ye, Likun Cao, Yi Wei, Jie Chen, Zhen Zhang, Shan Yao, Ting Duan, Bin Song
Blockade of OX40/OX40L pathway combined with ethylene-carbodiimide-fixed donor splenocytes induces donor-specific allograft tolerance in presensitized recipients
Xingqiang Lai, Zhongpeng Yao, Fen Ning, Lei Zhang, Jiali Fang, Guanghui Li, Lu Xu, Yunyi Xiong, Luhao Liu, Rongxin Chen, Junjie Ma, Zheng Chen
Protective effects of curcumin against neuroinflammation induced by Aβ25-35 in primary rat microglia: modulation of high-mobility group box 1, toll-like receptor 4 and receptor for advanced glycation end products expression
Wei He, Kaiming Yuan, Bin Ji, Yuan Han, Jun Li
Direct versus conventional anticoagulants for treatment of cancer associated thrombosis: a pooled and interaction analysis between observational studies and randomized clinical trials
Zhi-Chun Gu, Yi-Dan Yan, Sheng-Yan Yang, Long Shen, Ling-Cong Kong, Chi Zhang, An-Hua Wei, Zheng Li, Xin-Hua Wang, Hou-Wen Lin
Liver resection is beneficial for patients with colorectal liver metastases and extrahepatic disease
Kristina Hasselgren, Bengt Isaksson, Bjarne Ardnor, Gert Lindell, Magnus Rizell, Cecilia Strömberg, Per Loftås, Bergthor Björnsson, Per Sandström
Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits
Xiaohan Liu, Ying Hu, Lin Wu, Shujun Li
Establishing M1 stage subdivisions by incorporating radiological features and Epstein-Barr virus DNA for metastatic nasopharyngeal carcinoma
Wei-Hong Zheng, Xiao-Jun He, Fo-Ping Chen, Li Lin, Xiao-Dan Huang, Hua-Qiang Zhou, Jia Kou, Jia-Wei Lv, Jun Ma, Guan-Qun Zhou, Ying Sun
Scientometric analysis of mTOR signaling pathway in liver disease
Jing Fang, Long Pan, Qiu-Xia Gu, Sarun Juengpanich, Jun-Hao Zheng, Chen-Hao Tong, Zi-Yuan Wang, Jun-Jie Nan, Yi-Fan Wang
Development and validation of an individualized gene expression-based signature to predict overall survival in metastatic colorectal cancer
Shu-Biao Ye, Yi-Kan Cheng, Jian-Cong Hu, Feng Gao, Ping Lan
Surgical fixation of rib fractures decreases intensive care length of stay in flail chest patients
Xiangzhi Xiao, Shengchao Zhang, Juhua Yang, Jian Wang, Zhilong Zhang, Hao Chen
Three-dimensional printing flexible models: a novel technique for Nuss procedure planning of pectus excavatum repair
Lei Wang, Ting Guo, Hao Zhang, Sanhu Yang, Jiahe Liang, Yitong Guo, Qiuya Shao, Tiesheng Cao, Xiaofei Li, Lijun Huang
Low expression of A-kinase anchor protein 5 predicts poor prognosis in non-mucin producing stomach adenocarcinoma based on TCGA data
Zishao Zhong, Zhenhao Ye, Guihua He, Wang Zhang, Jing Wang, Suiping Huang
The role of preoperative 3D-ultrasound in intraoperative judgement for hysteroscopic adhesiolysis
Arvind Burjoo, Xingping Zhao, Lingxiao Zou, Xinyi Liu, Baiyun Zhang, Dabao Xu
Identification and analysis of dysregulated lncRNA and associated ceRNA in the pathogenesis of keloid
Xilei Duan, Yuemeng Wu, Zheng Zhang, Zhong Lu
Study on the antibacterial activities of emodin derivatives against clinical drug-resistant bacterial strains and their interaction with proteins
Chengjie Ji, Guang Xin, Feixia Duan, Wen Huang, Taichang Tan
Clinical significance and prognosis of supraclavicular lymph node metastasis in patients with thoracic esophageal cancer
Fudong Wang, Xiaosong Ge, Zhiqiang Wang, Yuan Weng, Rong Yin, Qingjun You
Identification of hub genes and potential molecular mechanisms of chickpea isoflavones on MCF-7 breast cancer cells by integrated bioinformatics analysis
Jia Wang, Hao Yu, Abulimit Yili, Yanhua Gao, Linlin Hao, Haji Akber Aisa, Songcai Liu
ALDH2 rs671 polymorphisms and the risk of cerebral microbleeds in Chinese elderly: the Taizhou Imaging Study
Zhen Zhu, Yanfeng Jiang, Mei Cui, Yingzhe Wang, Shuyuan Li, Kelin Xu, Kexun Zhang, Chengkai Zhu, Wanghong Xu, Li Jin, Weimin Ye, Chen Suo, Xingdong Chen
Distinguishing risk factors between congenital anophthalmia and microphthalmia using multivariable logistic regression
Yang Li, Zhijia Hou, Jingwen Ding, Ying Cui, Bixuan Qin, Dongmei Li
Rapid identification of pathogens involved in pediatric osteoarticular infections by multiplex PCR
Chi Gan, Jinfeng Hu, Qing Cao, Ruike Zhao, Yuchan Li, Zhigang Wang, Yue Tao, Xi Mo
Fentanyl inhibits the progression of gastric cancer through the suppression of MMP-9 via the PI3K/Akt signaling pathway
Chunlai Li, Yi Qin, Yu Zhong, Yinying Qin, Yi Wei, Li Li, Yubo Xie
An intronic polymorphism of NFATC1 gene shows a risk association with biopsy-proven acute rejection in renal transplant recipients
Zijie Wang, Hengcheng Zhang, Haiwei Yang, Ming Zheng, Miao Guo, Hao Chen, Li Sun, Zhijian Han, Jun Tao, Xiaobing Ju, Ruoyun Tan, Ji-Fu Wei, Min Gu
Sirolimus-based immunosuppression improves outcomes in liver transplantation recipients with hepatocellular carcinoma beyond the Hangzhou criteria
Sunbin Ling, Tingting Feng, Qifan Zhan, Xin Duan, Guangjiang Jiang, Tian Shen, Qiaonan Shan, Shengjun Xu, Qianwei Ye, Peng Liu, Beini Cen, Shusen Zheng, Xiao Xu
Forkhead box K1 regulates the malignant behavior of gastric cancer by inhibiting autophagy
Yixuan Wang, Wensheng Qiu, Ning Liu, Libin Sun, Zhao Liu, Shasha Wang, Peng Wang, Shihai Liu, Jing Lv
Mortality and chronic obstructive pulmonary disease in patients treated with endovascular revascularization of the infra-inguinal lower limb arteries from retrograde access
Zoltan Ruzsa, Rafał Januszek, Viktor Óriás, Michał Chyrchel, Joanna Wojtasik-Bakalarz, Jerzy Bartuś, Saleh Arif, Paweł Kleczyński, Tomasz Tokarek, Andras Nyerges, Agata Stanek, Dariusz Dudek, Stanisław Bartuś
Transanal versus nontransanal surgery for the treatment of primary rectal gastrointestinal stromal tumors: a 10-year experience in a high-volume center
Zifeng Yang, Wentai Guo, Rongkang Huang, Minhui Hu, Huaiming Wang, Hui Wang
Prognostic value of nasopharynx tumour volume in local-regional advanced nasopharyngeal carcinoma
Weiqiong Ni, Weixiang Qi, Fei Xu, Weiguo Cao, Cheng Xu, Jiayi Chen, Yunsheng Gao
Differentiation combined hepatocellular and cholangiocarcinoma from intrahepatic cholangiocarcinoma based on radiomics machine learning
Jun Zhang, Zixing Huang, Likun Cao, Zhen Zhang, Yi Wei, Xin Zhang, Bin Song
Impact of the use of vasoactive drugs in cardiac death donors on the early postoperative renal function and related complications in renal transplant recipients
Peng Zhang, Peihua Cao, Jiali Fang, Guanghui Li, Lei Zhang, Lu Xu, Shijing Mo, Xingqiang Lai, Luhao Liu, Yunyi Xiong, Wei Yin, Li Li, Rongxin Chen, Hailin Xu, Tao Zhang, Jiao Wan, Yuhe Guo, Junjie Ma, Zheng Chen
Multiparametric radiomics nomogram may be used for predicting the severity of esophageal varices in cirrhotic patients
Shang Wan, Yi Wei, Xin Zhang, Xijiao Liu, Weiwei Zhang, Yuhao He, Fang Yuan, Shan Yao, Yufeng Yue, Bin Song
Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways
Qunyan Yao, Shuyu Li, Xinlai Cheng, Yanting Zou, Yue Shen, Shuncai Zhang
External validation of the eighth edition of the TNM classification for lung cancer in 3,611 surgically treated patients at a single institution
Jia Wang, Nan Wu, Chao Lv, Yue Yang
Association of survival and genomic mutation signature with immunotherapy in patients with hepatocellular carcinoma
Qiyun Ou, Yunfang Yu, Anlin Li, Jie Chen, Tingting Yu, Xiaolin Xu, Xinxin Xie, Yongjian Chen, Dagui Lin, Qiaohong Zeng, Yuxin Zhang, Xudong Tang, Herui Yao, Baoming Luo
Machine learning for the prediction of severe pneumonia during posttransplant hospitalization in recipients of a deceased-donor kidney transplant
You Luo, Zuofu Tang, Xiao Hu, Shuo Lu, Bin Miao, Songlin Hong, Haiyun Bai, Chen Sun, Jiang Qiu, Huiying Liang, Ning Na
Elevated lipid levels in patients with achilles tendon ruptures: a retrospective matching study
Yu-Ping Yang, Li-Yuan Tao, Jia-Ning Gao, Peng Wang, Yan-Fang Jiang, Le-Min Zheng, Yi-Ming Zhao, Ying-Fang Ao
Novel prognostic nomograms for female patients with breast cancer and bone metastasis at presentation
Zhan Wang, Yonggang Cheng, Shi Chen, Haiyu Shao, Xiaowei Chen, Zenan Wang, Yucheng Wang, Hao Zhou, Tao Chen, Nong Lin, Zhaoming Ye
Multiclassifier fusion based on radiomics features for the prediction of benign and malignant primary pulmonary solid nodules
Yao Shen, Fangyi Xu, Wenchao Zhu, Hongjie Hu, Ting Chen, Qiang Li
Serum PON1 as a biomarker for the estimation of microvascular invasion in hepatocellular carcinoma
Guang-Yu Ding, Xiao-Dong Zhu, Yuan Ji, Guo-Ming Shi, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun, Cheng Huang
Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, Bombyx mori
Jiang-Bo Song, Kai-Ge Hao, Xin Chen, Yan-Hua Zhang, Zi-Lin Cheng, Shuang Mao, Yong-Xi Tang, Xiao-Ling Tong, Fang-Yin Dai
PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating IKs and ICaL—insights from human atrial modelling
Jieyun Bai, Yaosheng Lu, Andy Lo, Jichao Zhao, Henggui Zhang
Health status of middle-aged and older cancer survivors: a nationwide cross-sectional study from the China Health and Retirement Longitudinal Study (CHARLS)
Jiarui Li, Haiyu Pang, Zhao Sun, Lin Zhao, Chunmei Bai
Deep learning LI-RADS grading system based on contrast enhanced multiphase MRI for differentiation between LR-3 and LR-4/LR-5 liver tumors
Yunan Wu, Gregory M. White, Tyler Cornelius, Indraneel Gowdar, Mohammad H. Ansari, Mark P. Supanich, Jie Deng
A survey of primary care physician referral to bariatric surgery in Manitoba: access, perceptions and barriers
Mostafa El-Beheiry, Ashley Vergis, Jung-Un Choi, Kathleen Clouston, Krista Hardy
The combination of preoperative D-dimer and CA19-9 predicts lymph node metastasis and survival in intrahepatic cholangiocarcinoma patients after curative resection
Qichen Chen, Yiling Zheng, Hong Zhao, Jianqiang Cai, Liming Wang, Jianjun Zhao, Xinyu Bi, Zhiyu Li, Zhen Huang, Yefan Zhang, Jianguo Zhou, Jianxiong Wu
Benefits of adjuvant treatment including trastuzumab in HER2-positive pT1a-bN0M0 breast cancer: a systematic review and meta-analysis
Hye Yoon Lee, In-Soo Shin, Chai Hong Rim
Infections and risk of end-stage renal disease in patients with nephrotic syndrome: a nationwide population-based case-control study
Chien-Hung Lin, Peir-Haur Hung, Wen-Sheng Liu, Hsiao-Yun Hu, Chi-Jung Chung, Tsung-Hsien Chen
Clinical characteristics of perivascular space and brain CT perfusion in stroke-free patients with intracranial and extracranial atherosclerosis of different extents
Hui Wang, Zhi-Yu Nie, Meng Liu, Ren-Ren Li, Li-He Huang, Zheng Lu, Ling-Jing Jin, Yun-Xia Li
Red blood cell distribution width is associated with mortality after acute ischemic stroke: a cohort study and systematic review
Lu Wang, Changyi Wang, Simiao Wu, Yuxiao Li, Wen Guo, Ming Liu
Transcriptomic changes and potential regulatory mechanism of intrauterine human chorionic gonadotropin (hCG) co-cultured with peripheral blood mononuclear cells (PBMCs) infusion in mice with embryonic implantation dysfunction
Jiao Chen, Xuehan Zhao, Liangfei Ao, Tailang Yin, Jing Yang
A preliminary study on a patented intrauterine stent in the treatment of recurrent intrauterine adhesions with poor prognosis
Huan Huang, Lingxiao Zou, Aiqian Zhang, Xingping Zhao, Dabao Xu, Min Xue
Recommended changes for the 8th edition of the TNM classification for lung cancer-the findings of a single-institution evaluation
Jia Wang, Nan Wu, Chao Lv, Shi Yan, Yue Yang
Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis
Xi Zhang, Zonglin Dai, Eric H. Y. Lau, Chunping Cui, He Lin, Jun Qi, Weifeng Ni, Like Zhao, Qing Lv, Jieruo Gu, Zhiming Lin
High-resolution combined arterial spin labeling MR for identifying cerebral arterial stenosis induced by moyamoya disease or atherosclerosis
Jingyuan Ya, Da Zhou, Jiayue Ding, Yuchuan Ding, Xunming Ji, Qi Yang, Ran Meng
Polymyositis/dermatomyositis is a potential risk factor for acute respiratory failure: a pulmonary heart disease
Shih-Huei Syue, Yi-Hua Chang, Pei-Ju Shih, Cheng-Li Lin, Jun-Jun Yeh, Chia-Hung Kao
Association between IL-1beta and cardiovascular disease risk in patients with newly diagnosed, drug-naïve type 2 diabetes mellitus: a cross-sectional study
Kyong Hye Joung, Ji Min Kim, Sorim Choung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
Efficacy of Ca2+- or PO43−-conjugated mesoporous silica nanoparticles on dentinal tubule occlusion: an in-vitro assessment
Tianjia Yu, Yu Wang, Qiang Cai, Lin Wu
Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells
Zhixia Dong, Qian Zhuang, Min Ning, Shan Wu, Lungen Lu, Xinjian Wan
Pilot study: deficiency of mannose-binding lectin-dependent lectin pathway, a novel modulator in outcome from pancreatic islet auto-transplantation
Wen Yuan Chung, Cristina A. Pollard, Cordula Stover, Bashoo Naziruddin, Rohan Kumar, John Isherwood, Eyad Issa, Marlon F. Levy, Giuseppe Garcea, Ashley R. Dennison
Clinical characteristics and neuroimaging findings in eagle syndrome induced internal jugular vein stenosis
Chaobo Bai, Zhongao Wang, Jingwei Guan, Kexin Jin, Yuchuan Ding, Xunming Ji, Ran Meng
PITPNC1 fuels radioresistance of rectal cancer by inhibiting reactive oxygen species production
Yujing Tan, Ruoyang Shao, Jingyu Li, Hongyun Huang, Yanru Wang, Menglan Zhang, Jianyun Cao, Junde Zhang, Junguo Bu
Diagnosis and treatment of cervical incompetence combined with intrauterine adhesions
Waixing Li, Yueran Li, Xingping Zhao, Chunxia Cheng, Arvind Burjoo, Yimin Yang, Dabao Xu
Establishment of an animal model of intrauterine adhesions after surgical abortion and curettage in pregnant rats
Qing Feng, Bingsi Gao, Xingping Zhao, Huan Huang, Shuijing Yi, Lingxiao Zou, Xinyi Liu, Min Xue, Dabao Xu
A novel topoisomerase I inhibitor DIA-001 induces DNA damage mediated cell cycle arrest and apoptosis in cancer cell
Jiaqi Liu, Guohe Geng, Guang Liang, Ling Wang, Kuntian Luo, Jian Yuan, Shiguang Zhao
A two-circular RNA signature of donor circFOXN2 and circNECTIN3 predicts early allograft dysfunction after liver transplantation
Kun Wang, Xuyong Wei, Qiang Wei, Di Lu, Wangyao Li, Binhua Pan, Junli Chen, Haiyang Xie, Shusen Zheng, Xiao Xu
Effects of the different-sized external stents on vein graft intimal hyperplasia and inflammation
Qi Yang, Dong Lei, Shixing Huang, Yi Yang, Yang Yang, Xiaofeng Ye, Zhengwei You, Qiang Zhao
Prognostic value of chronic hepatitis B virus infection in patients with breast cancer in a hepatitis B virus endemic area
Weikai Xiao, Ying Zhou, Ping Yu, Anli Yang, Shaoquan Zheng, Hailin Tang, Xiaoming Xie
Myeloid derived suppressor cells are reduced and T regulatory cells stabilised in patients with advanced pancreatic cancer treated with gemcitabine and intravenous omega 3
John Isherwood, Ali Arshad, Wen Yuan Chung, Franscois Runau, Jill Cooke, Cristina Pollard, Lynne Howells, Jenny Fishwick, John Thompson, Matthew Metcalfe, William Steward, Ashley Dennison
Early removal of chest tubes leads to better short-term outcome after video-assisted thoracoscopic surgery lung resection
Tuo Xing, Xukai Li, Jun Liu, Ying Huang, Shilong Wu, Minzhang Guo, Hengrui Liang, Jianxing He
Non-invasive urinary sediment double-immunostaining predicts BK polyomavirus associated-nephropathy in kidney transplant recipients
Xu-Tao Chen, Wen-Fang Chen, Xiao-Tao Hou, Shi-Cong Yang, Hui-Fei Yang, Jun Li, Rong-Hai Deng, Yang Huang, Yelidana Nuertai, Chang-Xi Wang, Jiang Qiu, Gang Huang
Early estimation of the case fatality rate of COVID-19 in mainland China: a data-driven analysis
Shu Yang, Peihua Cao, Peipei Du, Ziting Wu, Zian Zhuang, Lin Yang, Xuan Yu, Qi Zhou, Xixi Feng, Xiaohui Wang, Weiguo Li, Enmei Liu, Ju Chen, Yaolong Chen, Daihai He, on behalf of COVID-19 evidence and recommendations working group
Ginsenoside Rg1 prevents early diabetic retinopathy via reducing retinal ganglion cell layer and inner nuclear layer cell apoptosis in db/db mice
Ye Gao, Yubin Ji, Yun Luo, Jiafu Sun, Guibo Sun, Xiaobo Sun
Cyclic helix B peptide ameliorates renal tubulointerstitial fibrosis induced by unilateral ureter obstruction via inhibiting NLRP3 pathway
Ruochen Qi, Weitao Zhang, Long Zheng, Ming Xu, Ruiming Rong, Tongyu Zhu, Cheng Yang
RNA sequencing analysis of small cell lung cancer reveals candidate chemotherapy insensitivity long noncoding RNAs and microRNAs
Peng Kuang, Peixin Chen, Lei Wang, Wei Li, Bin Chen, Yu Liu, Yi Xu, Hao Wang, Sha Zhao, Lingyun Ye, Feng Yu, Hongbin Ji, Yayi He
Re-excision or “wait and watch” —a prediction model in breast phyllodes tumors after surgery
Xue Chao, Xiaoyan Jin, Cui Tan, Peng Sun, Junwei Cui, Hui Hu, Qian Ouyang, Kai Chen, Wei Wu, Zhanghai He, Yan Nie, Herui Yao
Platelet-rich plasma-enhanced osseointegration of decellularized bone matrix in critical-size radial defects in rabbits
Yi Leng, Guangkai Ren, Yutao Cui, Chuangang Peng, Jincheng Wang, Dankai Wu, He Liu
Teasaponin suppresses Candida albicans filamentation by reducing the level of intracellular cAMP
Ying Li, Mingzhu Shan, Shihui Li, Yuechen Wang, Huan Yang, Ying Chen, Bing Gu, Zuobin Zhu
Development and validation of a predictive nomogram for the risk of recurrence in patients with cystitis glandularis
Jiao Hu, Chao Li, Xi Guo, Huihui Zhang, Huihuang Li, Dongxu Qiu, Guanghui Gong, Peihua Liu, Wenbiao Ren, Jinbo Chen, Xiongbing Zu
Laparoscopic liver resection with simultaneous diaphragm resection
Airazat M. Kazaryan, Davit L. Aghayan, Åsmund A. Fretland, Vasiliy I. Semikov, Alexander M. Shulutko, Bjørn Edwin
Early oral nutrition improves postoperative ileus through the TRPA1/CCK1-R-mediated mast cell-nerve axis
Da-Li Sun, Yu-Xing Qi, Ting Yang, Yue-Ying Lin, Shu-Min Li, Yi-Jun Li, Qing-Wen Xu, Yan-Bo Sun, Wei-Ming Li, Xiong-Zhi Chen, Peng-Yuan Xu
The role of the CDCA gene family in ovarian cancer
Chongxiang Chen, Siliang Chen, Ma Luo, Honghong Yan, Lanlan Pang, Chaoyang Zhu, Weiyan Tan, Qingyu Zhao, Jielan Lai, Huan Li
Tumor slice culture as a biologic surrogate of human cancer
Heidi L. Kenerson, Kevin M. Sullivan, Yongwoo D. Seo, Kathryn M. Stadeli, Cigdem Ussakli, Xiaowei Yan, Chris Lausted, Venu G. Pillarisetty, James O. Park, Kimberly J. Riehle, Matthew Yeh, Qiang Tian, Raymond S. Yeung

Review Article

Micronutrient management following bariatric surgery: the role of the dietitian in the postoperative period
Emma Osland, Hilary Powlesland, Taylor Guthrie, Carrie-Anne Lewis, Muhammed Ashraf Memon
Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases
Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long
Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review
Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont
Bariatric surgery and gastroesophageal reflux disease
Darius Ashrafi, Emma Osland, Muhammed Ashraf Memon
Laparoscopic adjustable gastric banding, the past, the present and the future
Niccolò Furbetta, Rosa Cervelli, Francesco Furbetta
Impact of bariatric surgery on cancer risk reduction
Debora S. Bruno, Nathan A. Berger
Endoscopic intragastric balloon: a gimmick or a viable option for obesity?
Katja Susanne Claudia Gollisch, Dirk Raddatz
Serological diagnosis of myasthenia gravis and its clinical significance
Yi Li, Yuyao Peng, Huan Yang
Human placental extract: a potential therapeutic in treating osteoarthritis
Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma
The diagnostic utility of pleural markers for tuberculosis pleural effusion
Man Zhang, Dan Li, Zhi-De Hu, Yuan-Lan Huang
Timing it right: the challenge of recipient selection for lung transplantation
Henry W. Ainge-Allen, Allan R. Glanville
Infection prophylaxis and management of viral infection
Emily S. Clausen, Lorenzo Zaffir
Using artificial intelligence to improve medical services in China
Ruiyang Li, Yahan Yang, Shaolong Wu, Kai Huang, Weirong Chen, Yizhi Liu, Haotian Lin
The combination of brain-computer interfaces and artificial intelligence: applications and challenges
Xiayin Zhang, Ziyue Ma, Huaijin Zheng, Tongkeng Li, Kexin Chen, Xun Wang, Chenting Liu, Linxi Xu, Xiaohang Wu, Duoru Lin, Haotian Lin
Advances in laboratory assays for detecting human metapneumovirus
Seri Jeong, Min-Jeong Park, Wonkeun Song, Hyon-Suk Kim
From the perspective of embryonic tendon development: various cells applied to tendon tissue engineering
Fangjie Qi, Zhantao Deng, Yuanchen Ma, Shuai Wang, Chang Liu, Fengjuan Lyu, Tao Wang, Qiujian Zheng
Diabetes and carotid artery disease: a narrative review
Niki Katsiki, Dimitri P. Mikhailidis
An update on chronic lung allograft dysfunction
Sakhee Kotecha, Miranda A. Paraskeva, Kovi Levin, Gregory I. Snell
Diabetes improvement and bariatric surgery—review of laparoscopic Roux-en-Y gastric bypass vs. laparoscopic vertical sleeve gastrectomy
Jeffrey Gu, Ashley Vergis
Antibody-mediated rejection after lung transplantation
Amit I. Bery, Ramsey R. Hachem
Killer immunoglobulin-like receptors/human leukocyte antigen class-I, a crucial immune pathway in cancer
Yi Xu, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Lingyun Ye, Yayi He, Caicun Zhou
Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system
Wei Liu, Jialong Yan, Weinan Pan, Mengjie Tang
Laparoscopic vertical sleeve gastrectomy, long and short-term impact on weight loss and associated co-morbidities
Leena Khaitan, Brian J. Shea
Radiographic assessment of the cup orientation after total hip arthroplasty: a literature review
Jing-Xin Zhao, Xiu-Yun Su, Zhe Zhao, Ruo-Xiu Xiao, Li-Cheng Zhang, Pei-Fu Tang
Elucidating the molecular signaling pathways of WAVE3
Urna Kansakar, Wei Wang, Vesna Markovic, Khalid Sossey-Alaoui
Cardiovascular risk reduction following metabolic and bariatric surgery
Wayne J. English, Matthew D. Spann, Chetan V. Aher, D. Brandon Williams

Surgical Technique

Hysteroscopic removal of angular retained products of conception hidden behind intrauterine adhesions using a 12-Fr spoon-shaped forceps
Aiqian Zhang, Huan Huang, Xian Qin, Arvind Burjoo, Nidhi, Dabao Xu, Chunxia Cheng
Hysteroscopic adhesiolysis using blunt spreading dissection technique in severe intrauterine adhesions with false passage
Xiuting Zhu, Xingping Zhao, Xiangyang Zeng, Arvind Burjoo, Yimin Yang, Dabao Xu

Study Protocol

A predictive analysis approach for paediatric and adult high-grade glioma: miRNAs and network insight
Anqi Liu, Hengyu Zhao, Banghao Sun, Xue Han, Danyang Zhou, Zhongqi Cui, Xiaoyu Ma, Jianan Zhang, Lijie Yuan

Technical Note

Anterior decompression through transoral axis slide and rotation osteotomy for salvage of failed posterior occipitocervical fusion: a novel technique note
Aimin Wu, Haiming Jin, Haicheng Dou, Xiangxiang Pan, Sunren Sheng, Chongan Huang, Xiangyang Wang