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Editorial

FAPα in pancreatic stellate cells upregulated by TGFβ1: a novel insight into pancreatic cancer progress
Yonggan Xue, Georg Beyer, Julia Mayerle
The interplay between miR-1245a and BRCA2 in colorectal cancer
Andreas Scorilas, Konstantina Panoutsopoulou, Panagiotis Tsiakanikas
Preemptive renal replacement therapy in critically ill patients?
Melanie Meersch, Alexander Zarbock
Protecting the lungs but hurting the kidneys: causal inference study for the risk of ventilation-induced kidney injury in ARDS
Haopu Yang, Panayiotis V. Benos, Georgios D. Kitsios
The role of prolyl oligopeptidase, understanding the puzzle
J. Arturo García-Horsman
Foxk1 regulates cancer progression
Daniel J. Garry, Geunho Maeng, Mary G. Garry
Predictive scores for hepatocellular carcinoma: a race with no winners?
Raffaella Tortora, Marco Guarracino, Giovan Giuseppe Di Costanzo
HPV in non-oropharyngeal head and neck cancer: does it matter?
Nicole C. Schmitt
COVID-19 is shifting the adoption of wearable monitoring and telemedicine (WearTel) in the delivery of healthcare: opinion piece
Ralph J. Mobbs, Daniel Ho, Wen Jie Choy, Callum Betteridge, Henry Lin
Structural heart disease: the revolution
Daniel Hernandez-Vaquero
Limitations of the Barcelona clinic liver cancer staging treatment strategy in hepatocellular carcinoma patients with performance status 1
Jung Hwan Yu, Jin-Woo Lee
Hysteroscopic removal of retained products of conception: historic approach or new iteration?
Usha Verma, Frank A. Crespo
Combination surgery for hepatocellular carcinoma: slashing and burning to improved survival
John C. McVey, Kazunari Sasaki
Whether immediate frozen-thawed embryo transfer improves IVF outcome in non-elective freeze all policy
Loris Marin, Amerigo Vitagliano
Changes in prognostic factors for patients with hepatocellular carcinoma underwent transarterial chemoembolization with the transition of the time: Child-Pugh class, Albumin-Bilirubin grade, and then
Takumi Kawaguchi, Shigeo Shimose, Sakura Yamamura, Dan Nakano, Masatoshi Tanaka, Takuji Torimura
Prevention and treatment of strokes associated with carotid artery stenosis: a research priority
Kosmas I. Paraskevas
Tumor-associated macrophages in solid tumor: friend or foe
Gaurav Pandey
Infective endocarditis in the 21th century
Francesco Nappi, Cristiano Spadaccio, Christos Mihos
Exploring new pathways in the treatment of hepatocellular cancer
Łukasz Masior, Michał Grąt
Clinical efficacy of liver resection combined with adjuvant microwave coagulation for patients with hepatocellular carcinoma: a promising approach to minimize recurrence?
Emanuele Felli, Zineb Cherkaoui, Patrick Pessaux
Traumatic macular holes: to operate, or not to operate, that is the question
Aristomenis Thanos, Bozho Todorich
Elective frozen embryo transfer (freeze-all): there seems to be no harm to transfer in the next immediate menstrual cycle
Matheus Roque, Sandro C. Esteves
Role of inflammatory indices in management of hepatocellular carcinoma—neutrophil to lymphocyte ratio
Vishal G. Shelat
Child Pugh and ALBI grade: past, present or future?
Margherita Rimini, Giulia Rovesti, Andrea Casadei-Gardini
Animal models closer to intrauterine adhesive pathology
Sung Woo Kim, Yoon Young Kim, Hoon Kim, Seung-Yup Ku
Editorial to the OCT Angiography in Glaucoma series
Gábor Holló
Correlation between cancer stem cells (CSCs) and tumor- infiltrating lymphocytes (TILs): do TILs interact with CSCs in non- small cell lung cancer?
Min Ling, Xiaolong Yang
Can lactate dehydrogenase (LDH) be used as a marker of severity of pneumonia in patients with renal transplant?
Carlos M. Luna, María M. Perín
Critical care echocardiography: diagnostic or prognostic?
Philippe Vignon
Early renal replacement therapy in acute kidney injury: a piece in the puzzle
Alexandre Braga Libório, Candice Torres de Melo Bezerra Cavalcante
Multinomial and ordinal Logistic regression analyses with multi-categorical variables using R
Jiaqi Liang, Guoshu Bi, Cheng Zhan
Neutrophil-to-lymphocyte ratio as a prognostic biomarker in hepatocellular carcinoma after transarterial chemoembolization
Soung Won Jeong
Implications of the COVID-19 pandemic on orthopaedic surgical residency and fellowship training: lost opportunity or novel experience?
Morad Chughtai, Anas A. Minkara, Thomas E. Kuivila, Brendan M. Patterson
Emerging multi-modal diagnostic approaches for moyamoya disease
Jae W. Song, Zhaoyang Fan
EFCC1 as a putative prognostic biomarker in lung adenocarcinoma
Shengnan Yu, Gao Zhang

Editorial Commentary

Distinct metabolic preference of atypical KRAS mutant
Heesun Cheong
Translating KEYNOTE-048 into practice recommendations for head and neck cancer
Petr Szturz, Jan B. Vermorken
New solutions to old problems—metabolic acidosis in chronic kidney disease
John Sy, Joline L. T. Chen, Kamyar Kalantar-Zadeh
A biologically effective dose threshold for stereotactic body radiation therapy—can we put the issue to BED?
Michael Mix, Jeffrey A. Bogart
Angiogenesis inhibitors for advanced hepatocellular carcinoma: in search for the right partner
Claudia Campani, Lorenza Rimassa, Nicola Personeni, Fabio Marra
Exenatide at mealtimes in type 1 diabetes—no MAG1C with exenatide, or with other glucagon-like peptide-1 receptor agonists
Sheila A. Doggrell
Devil in the detail: MET overexpression fails as surrogate marker for MET exon 14 splice site mutations in NSCLC
Matthew R. Strickland, Pasi A. Jänne
Camrelizumab—targeting a novel PD-1 epitope to treat hepatocellular carcinoma—targeting a novel PD-1 epitope to treat hepatocellular carcinoma
Yannick Sebastiaan Rakké, Dave Sprengers, Jaap Kwekkeboom, Jan Nicolaas Maria IJzermans
How to quantify monoclonal free light chains in plasma cell disorders: which mass spectrometry technology?
Caroline Moreau, Charles R. Lefevre, Olivier Decaux
Different perspectives and viewpoints on the postoperative management of EGFR-mutant lung cancer
Masayuki Nakao, Junji Ichinose, Yosuke Matsuura, Sakae Okumura, Mingyon Mun
EGFR and non-small cell lung cancer: implications for surgical practice
Gonzalo Varela, Nuria M. Novoa
Transbronchial cryobiopsy in the diagnosis of interstitial lung diseases: methodologies and perspectives from the Cryo-PID and COLDICE studies
Carey Suehs, Arnaud Bourdin, Isabelle Vachier, Nicolas Molinari, Micaela Romagnoli
Time to stop using hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma?—the SCOOP-2 trial experience
Markus Peck-Radosavljevic, Simona Bota, Florian Hucke
Of fungi and men: role of fungi in pancreatic cancer carcinogenesis
Heling Wang, Mjriam Capula, Bastiaan P. Krom, Dicky Yee, Elisa Giovannetti, Dongmei Deng
Why aren’t we getting consistent results for heart dose and mortality during thoracic radiotherapy?
Jianxin Xue, You Lu, Feng-Ming (Spring) Kong
Lenvatinib in elderly hepatocellular carcinoma patients, a new therapeutic option in first line
Gael S. Roth, Bleuenn Brusset, Thomas Decaens
Percutaneous liver biopsy: another option of hepatic sample collection approach in single-cell sequencing studies?
Zi-Yuan Zou, Jian-Gao Fan
Oncogene addiction and immune escape: friends or foes?
Pamela Abdayem, David Planchard
Towards a tailored systemic therapy for liver cancer
Rodolfo Sacco, Antonio Facciorusso
Adjuvant treatment with EGFR TKI in resected non-small cell lung cancer with EGFR mutation: all that glitters is not gold!
Alfonso Fiorelli, Fabiana Vitiello, Floriana Morgillo, Rosa Maria Di Crescenzo, Andrea Bianco, Mario Santini, Marina Di Domenico
Can exenatide flatten the post-prandial glucose curve in type 1 diabetes?
Charlotte K. Boughton, Roman Hovorka
Diagnosis in interstitial lung disease: highly confident histopathological results from transbronchial cryobiopsy are reliable
Lars Hagmeyer, Sandhya Matthes, Konrad Frank, Winfried Randerath
Prognostic models in papillary renal cell carcinoma
Kyrollis Attalla, Martin H. Voss, A Ari Hakimi
Combined locoregional and systemic therapy for advanced hepatocellular carcinoma: finally, the future is obscure
Khashayar Farsad, Nima Nabavizadeh, Adel Kardosh, Janice H. Jou, Willscott E. Naugler, Kenneth J. Kolbeck
Optimizing adjuvant therapy in EGFR-mutated non-small cell lung cancer
Annemarie F. Shepherd, Isabel R. Preeshagul, Narek Shaverdian, Abraham J. Wu, Daphna Y. Gelblum, Daniel R. Gomez, Andreas Rimner, Charles B. Simone II
Safety and preliminary signs of efficacy with the combination of pembrolizumab plus oxaliplatin and S-1 in Japanese gastric cancer patients
Maria Alsina, Elizabeth C. Smyth
VENUSS rising for papillary renal cell carcinoma prognostication?
Tomas Buchler
Caring about bone-modifying agents (BMAs) in women with early-stage breast cancer
Charles L. Shapiro
Oncolytic immunotherapy for metastatic cancer: lessons and future strategies
Zong-Sheng Guo
Dose escalation in the era of ablative lung irradiation: is more dose better when it comes to delivery of lung stereotactic body radiation therapy?
Fiori Alite, Anand Mahadevan
The adjuvant regimen for resected EGFR mutated patients: the “same-for-all-therapy” or not?
Cesare Gridelli, Francesca Casaluce
Tivozanib for hepatocellular carcinoma: not likely a new option
Florian Estrade, Fanny Le Du, Laurence Crouzet, Héloïse Bourien, Léa Muzellec, Julien Edeline
Veverimer for treatment of chronic metabolic acidosis in patients with chronic kidney disease
Anirudh R. Gone, Wei Chen
Tenascin-C: an emerging prognostic biomarker in diabetes
Saori Yonebayashi, Kazuko Tajiri, Siqi Li, Akira Sato
To sling or not to sling the shoulder after rotator cuff repair: which side are you on?
In-Ho Jeon, Erica Kholinne
Past, current and future management of secondary mitral valve disease: the importance of anatomic staging
Daniel H. Drake, Karen G. Zimmerman, David A. Sidebotham
Checkpoint inhibitors in primary mediastinal B-cell lymphoma: a step forward in refractory/relapsing patients?
Monica Balzarotti, Armando Santoro
Comment on a recent genetic study on the risk profile of Hirschsprung’s disease from a pediatric surgeon’s perspective
Nana Nakazawa-Tanaka, Geoffrey J. Lane, Atsuyuki Yamataka
Immune checkpoint inhibitor in liver cancer—unique regional differences
Shuntaro Obi, Takahisa Sato, Shinpei Sato
New evidence for liver venous deprivation: safety and feasibility for extended liver resections
Jiang Zhang, Christian J. Steib
IMPassionate about immunotherapy for TNBC: from change, to revolution and to cure?
Elena Vagia, Massimo Cristofanilli
Macrophage depletion: a potential immunomodulator treatment of endometriosis-associated pain?
Thomas M. D’Hooghe, Arne Vanhie, Valerie A. Flores, Hugh S. Taylor
Cigarette smoking and lung function decline beyond quitting
Jennifer L. Perret, E. Haydn Walters
The role of c-MET inhibitors in advanced hepatocellular carcinoma: now and future
Hyun Young Woo, Jeong Heo
Multikinase inhibitors to treat hepatocellular carcinoma failures to sorafenib—time has come for a better approach
Saleh A. Alqahtani, Massimo Colombo
Keynote-158 study, FDA granted accelerated approval of pembrolizumab for the treatment of patients with advanced PD-L1-positive cervical cancer
Edith Borcoman, Christophe Le Tourneau
A novel classification for local recurrence after surgical removal of renal cell cancer
Takeshi Yuasa
Editorial Commentary: Tivozanib versus sorafenib in patients with advanced renal cell carcinoma (TIVO-3): a phase 3, multicentre, randomised, controlled, open-label study
Mary E. Westerman, Christopher G. Wood
Adjuvant EGFR TKIs in NSCLC harboring EGFR mutations: looking for a consensus way
Ilaria Attili, Antonio Passaro, Lorenzo Spaggiari, Gianluca Spitaleri, Filippo de Marinis
Pembrolizumab (and friends) in pediatric malignancies: should we consider Hodgkin lymphoma a world of its own?
Mattia Algeri, Franco Locatelli
Proton stereotactic body radiation therapy for non-small cell lung cancer
Tejan Diwanji, Amit Sawant, Terence T. Sio, Nirav V. Patel, Pranshu Mohindra
Perifissural nodules: ready for application into lung cancer CT screening?
Anton Schreuder, Cornelia M. Schaefer-Prokop
Transbronchial cryobiopsy for diffuse parenchymal lung diseases: evidence that demands a (favorable) verdict
Matthew Aboudara, Fabien Maldonado
A large randomized clinical trial is necessary to establish the role of camrelizumab in hepatocellular carcinoma
Nishal Ravindran, Paul J. Thuluvath
The LncRNA, the phosphatase, and the macrophage: can they team up for support in inflammatory diseases?
Marcel Kuhny, Michael Huber
Transarterial chemoembolization (TACE) plus sorafenib: a real winning combination?
Xavier Adhoute, Rodolphe Anty, Marc Bourlière
Paving the way to precision medicine for diabetic kidney disease: the PRIORITY trial
Meir Schechter, Gil Leibowitz, Ofri Mosenzon
Combination therapy of transcatheter arterial chemoembolization with axitinib for the treatment of inoperable hepatocellular carcinoma
Kazuhiro Nouso, Akiko Wakuta, Kazuya Kariyama
Antibiotic stewardship in critically ill patients with suspected ventilator-associated pneumonia
Jumpei Yoshimura, Hideki Hashimoto, Kazuma Yamakawa
Dose matters for stereotactic body radiotherapy for early stage non-small cell lung cancer
Christian C. Okoye, C. Jane Cho, Mitchell Liu, Alexander V. Louie, Olusola Obayomi-Davies, Shankar Siva, Simon S. Lo
Veverimer: an advance in base therapy for metabolic acidosis
Clayton Brady, Elie R. Chemaly, James W. Lohr, Mark D. Parker
Cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) versus chemotherapy in luminal B early breast cancer: lessons from the CORALLEEN trial
Claudia De Angelis, Michail Ignatiadis, Martine Piccart-Gebhart
It is time to prepare for D-CARE!
Christoph Suppan, Marija Balic
Innate immune checkpoints for cancer immunotherapy: expanding the scope of non T cell targets
Luis F. Campesato, Chien-Huan Weng, Taha Merghoub
Endothelial growth factor receptor-mutant lung cancer and post-operative care management: one size does not fit all
Javeryah Safi, Sarah W. Gordon, Peter Lee, Howard Li, Patrick Nana-Sinkam, Rachit D. Shah, Ray W. Shepherd, Samira Shojaee
Romosozumab, clinical trials, and real-world care of patients with osteoporosis
E. Michael Lewiecki
More is not always better—what can be learned from the D-CARE trial
Georg Pfeiler, Michael Gnant
Socioeconomic gradient in health: mind the gap in ‘invisible’ disparities
Marialaura Bonaccio, Augusto Di Castelnuovo, Giovanni de Gaetano, Licia Iacoviello
Hard truths about preoperative knee X-rays
Wai-Keong Mak, Hamid Rahmatullah Bin Abd Razak
MET immunochemistry: a reliable screening tool for MET exon 14 skipping mutations in non-small cell lung cancer?
Melinda A. Pruis, Jan H. von der Thüsen, Hendrikus Jan Dubbink
Tivozanib in advanced inoperable hepatocellular carcinoma: considerations for patients with liver cirrhosis
Hyunwoo Oh, Jeong-Hoon Lee
Home spirometry to assess efficacy of pirfenidone in progressive unclassifiable interstitial lung disease: better the devil you know than the devil you don’t
Giacomo Sgalla, Pier-Valerio Mari, Luca Richeldi
Radiotherapy tumor volume for limited-stage small cell lung cancer: less is more
Antonin Levy, Corinne Faivre-Finn
Importance of genotyping patients for HLA-C*06:02: it provides not only pharmacogenetics implication in response to biologics drugs but also drug survival and drug-related costs information
Marina Talamonti, Marco Galluzzo

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis
Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont
Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach
Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks
Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?
Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani
Cataract complications study: an analysis of adverse effects among 14,520 eyes in relation to surgical experience
Alexander Aaronson, Antti Viljanen, Piotr Kanclerz, Andrzej Grzybowski, Raimo Tuuminen
Cost-effectiveness of intravitreal conbercept versus other treatments for wet age-related macular degeneration
Rui Chen, Bin Wu
Ligustilide modulates oxidative stress, apoptosis, and immunity to avoid pathological damages in bleomycin induced pulmonary fibrosis rats via inactivating TLR4/MyD88/NF-KB P65
Shu Luo, Junzuo Gong, Xiaoping Cao, Shiping Liu
Prognostic factors and the effect of radioiodine on patients with locally advanced differentiated thyroid cancer
Yao Yao, Shuai Cheng, Xinyu Xu, Xinyuan Chen, Wei Chen, Yichun Qian, Yuan Zhang
Which is the optimal management for locally advanced gastric cancer patients with TRG 0 and 1 after R0 resection?
Fei Ma, Yonglei Zhang, Liangqun Peng, Zhandong Zhang, Wei Yang, Junhui Chai, Bin Zhang, Sheqing Ji, Yawei Hua, Xiaobing Chen, Suxia Luo
Antibacterial peptides inhibit MC3T3-E1 cells apoptosis induced by TNF-α through p38 MAPK pathway
Rong-Jian Lu, He-Lin Xing, Chao-Jun Liu, Yao Shu, Biao Guo, Xiao-Yang Chu, Chun-Fang Wang, Lin Feng, Kai-Tao Yu
Estrogen receptor α is involved in the regulation of ITGA8 methylation in estrogen receptor-positive breast cancer
Jingxun Wu, Jianghong Cheng, Fuxing Zhang, Xianyang Luo, Zhiming Zhang, Shuai Chen
Percutaneous treatment with Mitraclip for functional mitral regurgitation: medium-term follow up according to left ventricular function
Isaac Pascual, Tomás Benito-González, Daniel Hernandez-Vaquero, Rodrigo Estévez-Loureiro, Rebeca Lorca, Carmen Garrote-Coloma, Pablo Avanzas, Javier Gualis, Antonio Adeba, Armando Pérez de Prado, César Morís, Felipe Fernández-Vázquez
The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx
Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Surgical outcomes and survival for T4 gastric cancer extending to the transverse colon
Gang-Cheng Wang, Ying-Jun Liu, Chong-Qing Gao, You-Cai Wang, Hui-Fang Lv, Bei-Bei Chen, Cai-Yun Nie, Xiao-Bing Chen, Su-Xia Luo
The patterns and management of fracture patients under COVID-19 outbreak in China
Pei Yu, Chuanlong Wu, Chengyu Zhuang, Tingjun Ye, Yin Zhang, Jingfeng Liu, Lei Wang
Intensity-modulated particle beam radiation therapy in the management of olfactory neuroblastoma
Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade J. Lu
RACGAP1 is transcriptionally regulated by E2F3, and its depletion leads to mitotic catastrophe in esophageal squamous cell carcinoma
Weifeng Zhao, Mengyao Wang, Chaojie Wang, Yingjun Liu, Huimin Liu, Suxia Luo
Initial experience of a MitraClip valve repair program in Spain
Daniel Henández-Vaquero, Isaac Pascual, Marcel Almendarez, Antonio Adeba, Alberto Alperi, Rebeca Lorca, Héctor Cubero-Gallego, Víctor León, Félix E. Fernández Suárez, David Fernández del Valle, César Morís, Pablo Avanzas
A CT-derived deep neural network predicts for programmed death ligand-1 expression status in advanced lung adenocarcinomas
Ying Zhu, Yang-Li Liu, Yu Feng, Xiao-Yu Yang, Jing Zhang, Dan-Dan Chang, Xi Wu, Xi Tian, Ke-Jing Tang, Can-Mao Xie, Yu-Biao Guo, Shi-Ting Feng, Zun-Fu Ke
Obesity and its effect on outcomes in same-day bilateral total knee arthroplasty
Ethan A. Remily, Nequesha S. Mohamed, Wayne A. Wilkie, Tyler Smith, Anthony Judice, Salvador Forte, James Nace, Ronald E. Delanois
ADNCR modulates neural stem cell differentiation and proliferation through the regulation of TCF3 expression
Ling Long, Chao Zeng, Honglei Chen, Taicheng Zhou, Lili Wu, Xiaodong Cai
“Liver parenchyma dissecting-first” method facilitates the Glissonean pedicle approach in anatomical laparoscopic hepatolobectomy
Liang Xiao, Zhiming Wang, Ledu Zhou
Extracellular ubiquitin promotes hepatoma metastasis by mediating M2 macrophage polarization via the activation of the CXCR4/ERK signaling pathway
Jiajing Cai, Qi Zhang, Xuemeng Qian, Jingdong Li, Qi Qi, Ru Sun, Jia Han, Xinfang Zhu, Mengyi Xie, Xiaolan Guo, Rong Xia
Anatomical femoral tunnel positioning in the medial patellofemoral ligament reconstruction: is the free-hand technique accurate?
Guilherme Moreira de Abreu-e-Silva, Felipe Antônio Ruy Buarque, Thiago Scherr Dias, Pengfei Lei, Elton Luis Ribeiro Bueno, Marco Antônio Percope de Andrade
Tumor mutation burden and JARID2 gene alteration are associated with short disease-free survival in locally advanced triple-negative breast cancer
Xiangmei Zhang, Jingping Li, Qing Yang, Yanfang Wang, Xinhui Li, Yunjiang Liu, Baoen Shan
Determinants of intraocular lens tilt and decentration after cataract surgery
Xiaoxun Gu, Xiaoyun Chen, Guangyao Yang, Wei Wang, Wei Xiao, Guangming Jin, Lanhua Wang, Ye Dai, Xiaoting Ruan, Zhenzhen Liu, Lixia Luo, Yizhi Liu
Evaluation of the updated “Candida score” with Sepsis 3.0 criteria in critically ill patients
Dongkai Li, Jiahui Zhang, Wen Han, Guangxu Bai, Wei Cheng, Na Cui
Pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement
Xu-Tao Chen, Rong-Hai Deng, Shi-Cong Yang, Xiao-Tao Hou, Jun Li, Yan-Yang Chen, Hui-Fei Yang, Ze-Yuan Wang, Chang-Xi Wang, Jiang Qiu, Li-Zhong Chen, Wen-Fang Chen, Gang Huang
Genetic alterations in cfDNA of benign and malignant thyroid nodules based on amplicon-based next-generation sequencing
Siting Cao, Shuang Yu, Yali Yin, Lei Su, Shubin Hong, Yingying Gong, Weiming Lv, Yanbing Li, Haipeng Xiao
Interaction between common variants of MDM2 and PPP1R13L and CD3EAP and TP53 SNPs in relation to lung cancer risk among Chinese
Jiaoyang Yin, Wei Hou, Ulla Vogel, Yegang Ma, Chunhong Wang, Huiwen Wang, Zhenxiang Sun
Hepatobiliary phase hypointensity on gadobenate dimeglumine- enhanced magnetic resonance imaging may improve the diagnosis of hepatocellular carcinoma
Yueming Li, Jianwei Chen, Shuping Weng, Chuan Yan, Rongping Ye, Yuemin Zhu, Liting Wen, Dairong Cao, Jinsheng Hong
Functional mitral regurgitation: structural modifications with percutaneous valve repair with MitraClip
Alberto Alperi, Pablo Avanzas, Isaac Pascual, Antonio Adeba, Rebeca Lorca, Victor León, Marcel Almendarez, Hector Cubero-Gallego, Iria Silva-Conde, César Moris, Daniel Hernandez-Vaquero
Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy
Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong
Developmental characteristics of the cytokine profile in aqueous humor and its relationship with the inflammatory response in children
Weiyi Lai, Xiaohang Wu, Dongni Wang, Zhenzhen Liu, Duoru Lin, Lanqin Zhao, Weirong Chen, Haotian Lin, Yizhi Liu
Quantitative analysis of multiphase magnetic resonance images may assist prediction of histopathological grade of small hepatocellular carcinoma
Shuping Weng, Xuru Xu, Yueming Li, Chuan Yan, Jianwei Chen, Rongping Ye, Yuemin Zhu, Liting Wen, Jinsheng Hong
Development and validation of a four-microRNA signature for placenta accreta spectrum: an integrated competing endogenous RNA network analysis
Tian Yang, Na Li, Rui Hou, Chong Qiao, Caixia Liu
Real-world data on the effectiveness and safety of interferon-alpha-2a intralesional injection for the treatment of focally recalcitrant mycosis fungoides
Shi-Yu Zhang, Zhao-Rui Liu, Lu Yang, Tao Wang, Jie Liu, Yue-Hua Liu, Kai Fang
Temporal changes of COVID-19 pneumonia by mass evaluation using CT: a retrospective multi-center study
Chao Wang, Peiyu Huang, Lihua Wang, Zhujing Shen, Bin Lin, Qiyuan Wang, Tongtong Zhao, Hanpeng Zheng, Wenbin Ji, Yuantong Gao, Junli Xia, Jianmin Cheng, Jianbing Ma, Jun Liu, Yongqiang Liu, Miaoguang Su, Guixiang Ruan, Jiner Shu, Dawei Ren, Zhenhua Zhao, Weigen Yao, Yunjun Yang, Bo Liu, Minming Zhang
Impact of the number of examined lymph nodes on stage migration in node-negative gastric cancer patients: a Chinese multi-institutional analysis with propensity score matching
Pengfei Gu, Jingyu Deng, Wei Wang, Zhenning Wang, Zhiwei Zhou, Huimian Xu, Han Liang
Ventricular arrhythmias in patients with functional mitral regurgitation and implantable cardiac devices: implications of mitral valve repair with Mitraclip®
Tomás Benito-González, Xavier Freixa, Cosmo Godino, Maurizio Taramasso, Rodrigo Estévez-Loureiro, Daniel Hernandez-Vaquero, Ana Serrador, Luis Nombela-Franco, David Grande-Prada, Ignacio Cruz-González, Rodolfo San Antonio, Michele Galasso, Mara Gavazzoni, Carmen Garrote, Antonio Portolés-Hernández, Pablo Avanzas, Felipe Fernández-Vázquez, Isaac Pascual
Dissociation between airway and systemic autoantibody responses in chronic obstructive pulmonary disease
Zhenyu Liang, Fei Long, Kuimiao Deng, Fengyan Wang, Jing Xiao, Yuqiong Yang, Dongying Zhang, Weili Gu, Jiaxuan Xu, Wenhua Jian, Weijuan Shi, Jinping Zheng, Xin Chen, Yang Gao, Qun Luo, Martin R. Stampfli, Tao Peng, Rongchang Chen
Coronavirus disease 2019: MRI examination procedures and infection prevention and protection
Xiaoyong Shen, Jinwen Meng, Qidong Wang, Lingmei Ni, Zifeng Zhong, Shaohua Hu, Feng Chen
Blocking the Notch signal transduction pathway promotes tumor growth in osteosarcoma by affecting polarization of TAM to M2 phenotype
Shuguang Ren, Xiangmei Zhang, Yueyang Hu, Jianhua Wu, Yingchao Ju, Xu Sun, Yunjiang Liu, Baoen Shan
Upregulation of STAT1-CCL5 axis is a biomarker of colon cancer and promotes the proliferation of colon cancer cells
Mengke Niu, Ming Yi, Bing Dong, Suxia Luo, Kongming Wu
Long term follow up of percutaneous treatment for degenerated Mitroflow prosthesis with self-expanding transcatheter aortic valve implantation
Isaac Pascual, Marcel Almendárez, Rut Álvarez Velasco, Antonio Adeba, Daniel Hernández-Vaquero, Rebeca Lorca, Rocío Díaz, Alberto Alperi, Héctor Cubero-Gallego, Jose Rozado, César Morís, Pablo Avanzas
Effect of cataract surgery on quality of life for patients with severe vision impairment due to age-related macular degeneration
Claudia Taipale, Andrzej Grzybowski, Raimo Tuuminen
The efficacy and complications of computed tomography guided microwave ablation in lung cancer
Bin Chen, Wei Li, Yu Liu, Shengxiang Ren, Lei Wang, Hao Wang, Sha Zhao, Lingyun Ye, Yayi He, Caicun Zhou
The combination of forskolin and VPA increases gene expression efficiency to the hypoxia/neuron-specific system
Zhimin Pan, Jinsoo Oh, Lu Huang, Zhaoxun Zeng, Pingguo Duan, Zhiyun Li, Yeomin Yun, Janghwan Kim, Yoon Ha, Kai Cao
Comparison of iPTH and calcium levels between total thyroidectomy and lobectomy: a prospective study of 840 thyroid cancers with three years of follow-up
Xiaoli Liu, Xuehai Bian, Changlin Li, Jingwei Xin, Qingfeng Fu, Chunhai Zhang, Fang Li, Jinxi Jiang, Gianlorenzo Dionigi, Hui Sun
Identification of hub genes in diabetic kidney disease via multiple-microarray analysis
Yumin Zhang, Wei Li, Yunting Zhou
Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies
Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Review Article

Human placental extract: a potential therapeutic in treating osteoarthritis
Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma
Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases
Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long
Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review
Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont
Serological diagnosis of myasthenia gravis and its clinical significance
Yi Li, Yuyao Peng, Huan Yang
Carotid intraplaque haemorrhage: pathogenesis, histological classification, imaging methods and clinical value
Mathilde Mura, Nellie Della Schiava, Anne Long, Erica N. Chirico, Vincent Pialoux, Antoine Millon
Lung emphysema and lung cancer: what do we know about it?
Ramón A. Tubío-Pérez, María Torres-Durán, Mónica Pérez-Ríos, Alberto Fernández-Villar, Alberto Ruano-Raviña
Targeted therapies for gastroesophageal cancers
Andrew Hsu, Rani Chudasama, Khaldoun Almhanna, Alexander Raufi
Locoregional gastric cancer: a narrative review of multidisciplinary management
Ari Pelcovits, Khaldoun Almhanna
A narrative review of the interpretation of guidelines for the treatment of infective endocarditis
Umberto Benedetto, Sanjeet Singh Avtaar Singh, Cristiano Spadaccio, Marc R. Moon, Francesco Nappi
Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: Quo Vadis?
Stergios Boussios, Michele Moschetta, Peeter Karihtala, Eleftherios P. Samartzis, Matin Sheriff, George Pappas-Gogos, Mehmet Akif Ozturk, Mario Uccello, Afroditi Karathanasi, Michail Tringos, Elie Rassy, Nicholas Pavlidis
Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship
Gábor Holló
The less invasive paradox, why carotid artery stenting is not suitable for the high-risk patient
Matthew Machin, Safa Salim, Sarah Onida, Alun Huw Davies
Management and prognosis of acute extracranial internal carotid artery occlusion
Lukas Mayer, Astrid Grams, Christian F. Freyschlag, Maria Gummerer, Michael Knoflach
CT imaging features of carotid artery plaque vulnerability
Alessandro Murgia, Marco Erta, Jasjit S. Suri, Ajay Gupta, Max Wintermark, Luca Saba
Approaches to quantify optical coherence tomography angiography metrics
Bingyao Tan, Ralene Sim, Jacqueline Chua, Damon W. K. Wong, Xinwen Yao, Gerhard Garhöfer, Doreen Schmidl, René M. Werkmeister, Leopold Schmetterer
Robotics and minimally invasive esophageal surgery
Ealaf Shemmeri, Jon O. Wee
Redo aortic valve replacement for prosthesis endocarditis in patients previously classified as high or prohibitive risk: a narrative review
Francesco Pollari, Renate Ziegler, Francesco Nappi, Irena Großmann, Jörg Steinmann, Theodor Fischlein
Revisiting the guidelines and choice the ideal substitute for aortic valve endocarditis
Francesco Nappi, Sanjeet Singh Avtaar Singh, Cristiano Spadaccio, Christophe Acar
Nipple-areola complex reconstruction in transgender patients undergoing mastectomy with free nipple grafts: a systematic review of techniques and outcomes
Samyd S. Bustos, Doga Kuruoglu, Maria Yan, Valeria P. Bustos, Antonio J. Forte, Pedro Ciudad, Esther A. Kim, Gabriel A. Del Corral, Oscar J. Manrique
Diabetes and carotid artery disease: a narrative review
Niki Katsiki, Dimitri P. Mikhailidis
Cholesterol, carotid artery disease and stroke: what the vascular specialist needs to know
Kosmas I. Paraskevas, Frank J. Veith, Hans-Henning Eckstein, Jean-Baptiste Ricco, Dimitri P. Mikhailidis
Transcatheter aortic valve replacement (TAVR): expanding indications to low-risk patients
Hector Cubero-Gallego, Christian Dam, Juan Meca, Pablo Avanzas
Choice of transcatheter heart valve: should we select the device according to each patient’s characteristics or should it be “one valve fits all”?
Matthias Renker, Won-Keun Kim
Pulmonary regurgitation after repaired tetralogy of Fallot: surgical versus percutaneous treatment
Juan Antonio Meca Aguirrezabalaga, Jacobo Silva Guisasola, Rocío Díaz Méndez, Alain Eliott Escalera Veizaga, Daniel Hernández-Vaquero Panizo
The management of carotid restenosis: a comprehensive review
Francesco Stilo, Nunzio Montelione, Rosalinda Calandrelli, Marisa Distefano, Francesco Spinelli, Vincenzo Di Lazzaro, Fabio Pilato
A pilot protocol and review of triple neuroprotection with targeted hypothermia, controlled induced hypertension, and barbiturate infusion during emergency carotid endarterectomy for acute stroke after failed tPA or beyond 24-hour window of opportunity
Sherif Sultan, Yogesh Acharya, Nora Barrett, Niamh Hynes
Postoperative Endophthalmitis and Toxic Anterior Segment Syndrome Prophylaxis: 2020 Update
Jesse D. Sengillo, Ying Chen, Diley Perez Garcia, Stephen G. Schwartz, Andrzej Grzybowski, Harry W. Jr Flynn
Endometriosis and ovarian cancer risk, an epigenetic connection
Sarah Brunty, Brenda Mitchell, Nadim Bou-Zgheib, Nalini Santanam
Personalized-medicine on carotid endarterectomy and stenting
Gaetano Lanza, David Giannandrea, Jessica Lanza, Stefano Ricci, Gian Franco Gensini
Neoadjuvant treatment for newly diagnosed advanced ovarian cancer: where do we stand and where are we going?
Michele Moschetta, Stergios Boussios, Elie Rassy, Eleftherios P. Samartzis, Gabriel Funingana, Mario Uccello
Current and future immunotherapy approaches in ovarian cancer
Nazım Can Demircan, Stergios Boussios, Tolga Tasci, Mehmet Akif Öztürk
Intraoperative image guidance for lateral position surgery
Peter R. Swiatek, Michael H. McCarthy, Joseph Weiner, Shivani Bhargava, Avani S. Vaishnav, Sravisht Iyer
Progress in the esophagogastric anastomosis and the challenges of minimally invasive thoracoscopic surgery
Luigi Bonavina
Manometric pattern progression in esophageal achalasia in the era of high-resolution manometry
Renato Salvador, Mario Costantini, Salvatore Tolone, Pietro Familiari, Ermenegildo Galliani, Bastianello Germanà, Edoardo Savarino, Stefano Merigliano, Michele Valmasoni
Fluorescence-guided surgery of the esophagus
Paul Chandler, Ory Wiesel, Danny A. Sherwinter
Narrative review on serous primary peritoneal carcinoma of unknown primary site: four questions to be answered
Elie Rassy, Tarek Assi, Stergios Boussios, Joseph Kattan, Julie Smith-Gagen, Nicholas Pavlidis
Lung transplantation for emphysema
Ilhan Inci
Lens regeneration in humans: using regenerative potential for tissue repairing
Zhenzhen Liu, Ruixin Wang, Haotian Lin, Yizhi Liu
New frontiers in esophageal radiology
Eric J. Schmidlin, Ritu R. Gill
Catheter-based treatment of tricuspid regurgitation: state of the art
Marcel Santaló-Corcoy, Lluís Asmarats, Chi-Hion Li, Dabit Arzamendi
The emerging prospects of circular RNA in tumor immunity
Lingjiao Meng, Pingan Ding, Sihua Liu, Ziyi Li, Meixiang Sang, Baoen Shan
Timing of carotid endarterectomy and clinical outcomes
Bilal Azhar, Arsalan Wafi, James Budge, Ian Loftus
Brain imaging biomarkers of carotid artery disease
Hediyeh Baradaran, Ajay Gupta
Preoperative planning for intraoperative navigation guidance
Shahbaaz A. Sabri, Philip J. York
Ovarian cancer risk assessment in the era of next-generation sequencing
Renata Colombo Bonadio, Jéssica Rojas Crespo, Maria Del Pilar Estevez-Diz
Fugitive aerosols in the intensive care unit: a narrative review
Ciarraí O’Toole, Mary Joyce, James A. McGrath, Andrew O’Sullivan, Miriam A. Byrne, Ronan MacLoughlin
Reviewing the value of leukocytes cell population data (CPD) in the management of sepsis
Eloísa Urrechaga
Current practices on genetic testing in ovarian cancer
Florentia Fostira, Marios Papadimitriou, Christos Papadimitriou
Tetralogy of Fallot: cardiac imaging evaluation
Carlos Jerjes Sánchez Ramírez, Leopoldo Pérez de Isla
The modern approach to esophageal palliative and emergency surgery
Anny Godin, Moishe Liberman
Outcomes with percutaneous mitral repair vs. optimal medical treatment for functional mitral regurgitation: systematic review
Hector Cubero-Gallego, Daniel Hernandez-Vaquero, Pablo Avanzas, Marcel Almendarez, Antonio Adeba, Rebeca Lorca, Jose Rozado, Alain Escalera, Jacobo Silva, Cesar Moris, Isaac Pascual
Upfront debulking surgery for high-grade serous ovarian carcinoma: current evidence
Orestis Tsonis, Fani Gkrozou, Konstantinos Vlachos, Minas Paschopoulos, Michail C. Mitsis, Nikolaos Zakynthinakis-Kyriakou, Stergios Boussios, George Pappas-Gogos
Metformin and ovarian cancer: the evidence
Elina Urpilainen, Ulla Puistola, Stergios Boussios, Peeter Karihtala
Current innovation in virtual and augmented reality in spine surgery
Frank J. Yuk, Georgios A. Maragkos, Kosuke Sato, Jeremy Steinberger
Intraoperative image guidance for endoscopic spine surgery
Jason I. Liounakos, Gregory W. Basil, Hikari Urakawa, Michael Y. Wang
Narrative review of intraoperative image guidance for transforaminal lumbar interbody fusion
Joseph A. Weiner, Michael H. McCarthy, Peter Swiatek, Philip K. Louie, Sheeraz A. Qureshi
Future of immune checkpoint inhibitors: focus on tumor immune microenvironment
Yunlong Jia, Lihua Liu, Baoen Shan
Opioid transdermal delivery system: a useful method for pain management in children
Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Giorgio Attinà, Palma Maurizi, Alberto Romano, Antonio Ruggiero
Magnetic resonance imaging of carotid plaques: current status and clinical perspectives
Mohamed Kassem, Alexandru Florea, Felix M. Mottaghy, Robert van Oostenbrugge, M. Eline Kooi
Metabolic programming of tumor associated macrophages in the context of cancer treatment
Thomas Crezee, Katrin Rabold, Lisanne de Jong, Martin Jaeger, Romana T. Netea-Maier
Optical coherence tomography angiography in glaucoma
Masoud Aghsaei Fard, Robert Ritch
Pain assessment in clinical trials: a narrative review
Livia Puljak, Krste Boric, Svjetlana Dosenovic
Intraoperative image guidance for the surgical treatment of adult spinal deformity
Venkat Boddapati, Joseph M. Lombardi, Hikari Urakawa, Ronald A. Lehman
Sharing of decision-making for infective endocarditis surgery: a narrative review of clinical and ethical implications
Francesco Pollari, Cristiano Spadaccio, Michela Cuomo, Massimo Chello, Antonio Nenna, Theodor Fischlein, Francesco Nappi
The role of lens extraction in glaucoma management
Jolly L. Tsui, Noel C. Chan, Clement C. Tham
Fusion imaging for transcatheter mitral and tricuspid interventions
Isaac Pascual, Alberto Pozzoli, Maurizio Taramasso, Francesco Maisano, Edwin C. Ho
Evolving treatment paradigms in esophageal cancer
Ilit Turgeman, Irit Ben-Aharon
The modern approach to esophagectomy—review of the shift towards minimally invasive surgery
Daniel P. Dolan, Scott J. Swanson
Inflammation of carotid plaques and risk of cerebrovascular events
Pavel Poredos, Igor D. Gregoric, Mateja K. Jezovnik
Impact of cerebral ischemic lesions on the outcome of carotid endarterectomy
Rodolfo Pini, Andrea Vacirca, Sergio Palermo, Enrico Gallitto, Chiara Mascoli, Mauro Gargiulo, Gianluca Faggioli
Advances in imaging for lung emphysema
Katharina Martini, Thomas Frauenfelder
Treatment for metastatic adenocarcinoma of the stomach and gastroesophageal junction: 2020
Andrew Hsu, Adam S. Zayac, Aditya Eturi, Khaldoun Almhanna
Emerging neo adjuvants for harnessing therapeutic potential of M1 tumor associated macrophages (TAM) against solid tumors: Enusage of plasticity
Vinod Nadella, Manoj Garg, Sonia Kapoor, Tuhar Singh Barwal, Aklank Jain, Hridayesh Prakash
Bronchoscopic lung volume reduction: status quo
Massa Zantah, Andrew J. Gangemi, Gerard J. Criner
Current state of navigation in spine surgery
Nathaniel Rawicki, James E. Dowdell, Harvinder S. Sandhu
The quest for the optimal surgical management of tricuspid valve endocarditis in the current era: a narrative review
Francesco Nappi, Cristiano Spadaccio, Christos Mihos, Kasra Shaikhrezai, Christophe Acar, Marc R. Moon
Intraoperative image guidance for cervical spine surgery
Sertac Kirnaz, Harry Gebhard, Taylor Wong, Raj Nangunoori, Franziska Anna Schmidt, Kosuke Sato, Roger Härtl
Management of internal carotid artery near-occlusion: the need for updated evidence
Constantine N. Antonopoulos, Alexandros Giosdekos, Spyridon N. Mylonas, Christos D. Liapis
Why are we still debating criteria for carotid artery stenosis?
Victor J. Del Brutto, Heather L. Gornik, Tatjana Rundek
The conundrum of asymptomatic carotid stenosis—determinants of decision and evidence
José Fernandes e Fernandes, Luis Mendes Pedro, Isabel Gonçalves
Treatment of the extracranial carotid artery in tandem lesions during endovascular treatment of acute ischemic stroke: a systematic review and meta-analysis
Joyce Hellegering, Maarten Uyttenboogaart, Reinoud P. H. Bokkers, Mostafa El Moumni, Clark J. Zeebregts, Maarten J. van der Laan
The current state of navigation in robotic spine surgery
Meng Huang, Tyler A. Tetreault, Avani Vaishnav, Philip J. York, Blake N. Staub
Intraoperative risks of radiation exposure for the surgeon and patient
Nathaniel W. Jenkins, James M. Parrish, Evan D. Sheha, Kern Singh
Metabolic reprograming of tumor-associated macrophages
Abhishek Puthenveetil, Shweta Dubey
Advances in pharmacotherapy of cataracts
Jingjie Xu, Qiuli Fu, Xiangjun Chen, Ke Yao
Asymptomatic Carotid Stenosis and Risk of Stroke (ACSRS) study: what have we learned from it?
Kosmas I. Paraskevas, Andrew N. Nicolaides, Stavros K. Kakkos
Paraesophageal hernia: to fundoplicate or not?
Daniel Solomon, Eliahu Bekhor, Hanoch Kashtan
Percutaneous mitral repair: current and future devices
Rodrigo Estévez-Loureiro, Tomás Benito-González, Carmen Garrote-Coloma, Felipe Fernández-Vázquez, Pablo Avanzas, Miguel Piñón, Isaac Pascual
Systemic anti-cancer treatment in malignant ovarian germ cell tumours (MOGCTs): current management and promising approaches
Mario Uccello, Stergios Boussios, Eleftherios P. Samartzis, Michele Moschetta
Management of asymptomatic carotid stenosis
J. David Spence

Column in Laboratory Medicine

SARS-CoV-2 antibodies titration: a reappraisal
Giuseppe Lippi, Mario Plebani