Role of skin homing T cells in acute dengue infection

Dengue viral infections are one of the most important emerging vector borne diseases, infecting an estimated 390 million individuals annually, resulting in 96 million clinically apparent infections (1). A total of 70% of the burden of dengue infection is seen in resource poor countries in Asia, where it is a significant public health problem. Although a recently concluded phase 3 trial of a dengue vaccine in Asia, showed that the vaccine was safe and highly immunogenic, its overall efficacy was 56.5% (2).