Using transperineal ultrasound to predict labor onset—reply
Letter to the Editor

Using transperineal ultrasound to predict labor onset—reply

Yang Yu, Fanghua Peng, Zhikun Zhang

Pelvic Floor Research Group, Department of Ultrasound and Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, China

Correspondence to: Zhikun Zhang. Tianjin Central Hospital of Gynecology Obstetrics, No. 156 Nankai Sanma Road Nankai District, Tianjin 300100, China. Email:

Provenance and Peer Review: This article was commissioned by the editorial office, Annals of Translational Medicine. The article did not undergo external peer review.

Response to: Nowak PM, Araujo Júnior E. Transperineal ultrasound to predict vaginal deliveries. Ann Transl Med 2020;8:574.

Submitted May 23, 2020. Accepted for publication Jun 23, 2020.

doi: 10.21037/atm-20-3918

Thank you for the constructive editorial commentary on our recently published article “Using transperineal ultrasound to predict labor onset”.

We agree with the Prof. Edward Araujo Júnior that the majority of pregnant women then will go into labor after 39 weeks, and induction of labor at 39 weeks in low-risk women did not result in a significantly lower frequency of a composite adverse perinatal outcome. And induction of labor in term at 39 weeks of gestation will increase the cost. That is the reason we are doing our research.

Labor onset occurs as a switch from uterine quiescence to uterine contraction, and it is the result of multiple factors. However, those factors promoting the labor onset are poorly understand (1). Because there are fundamental physiological different between human and other animals, the information derived from animal models has had only limited applicability (2). Due to the unclear labor initiation mechanism, the clinician diagnosis labor onset only by observing the clinical manifestations, which mainly depends on the experience of a clinician. But the time of labor onset are most concerned by clinician, pregnant women and their families in our daily work. And pregnant women will receive more attention in the family in China. Accurate determination of labor time can help pregnant women and their families prepare psychologically, and also better assist clinicians to prepare for the next medical measures.

Prof. Edward Araujo Júnior affirmed the value of ultrasound for the evaluating the progress of labor. Many studies have reported that intrapartum ultrasound can predict pregnancy outcome, including time to delivery and delivery mode (3,4). With the development of ultrasound in the prediction of labor onset, ultrasonic examination has become an integral part of intrapartum as well as antepartum care. Besides, several studies have reported the ultrasound’s important role in predicting the time of labor onset (5-7). Ultrasound is a good method which can transform the subjective measurement indexes of clinicians into more comparable and objective ultrasonic parameters, so as to better observe the fetal head decline and the changes of bone birth canal in the third trimester of pregnancy.

In China, ultrasound is a routine test for women after 39 weeks gestation. We can do transperineal ultrasound after the routine test avoiding the multiple trips to hospital. Of course, pregnant women will pay a certain amount of medical expenses. But comparing to the medical cost of inducing labor for a woman who will be in labor for a short time, this medical resources is a very little waste (8). For postterm pregnant women, using transperineal ultrasound to evaluate prenatal condition can also help decrease the rate of meconium staining in the amniotic fluid, 5-min Apgar score less than 7, need for newborn resuscitation and admission to the NICU (9). These are huge medical bills and family burdens.

Most recent studies predicting labor onset had a minimum forecast of seven days. For example, in Rozenberg’s study, they reported cervical length was as efficient as the Bishop score in predicting spontaneous onset of labor within 7 days (10). Our study seeks to find more ultrasound indicators to predict labor onset, and those indicators will be used in our research on shorter time to labor prediction. That will provide clinicians with more objective auxiliary examination indicators. In addition, transperineal ultrasound is a main examination methods of pelvic ultrasound, so we can also collect the data of pelvic floor change and fetal head position change at the same time. These data will be used for our further research on preterm birth and postterm pregnant women. Our research team will further enrich the research data, refining group, resulting in a more positive research conclusion.


Funding: We gratefully acknowledge the support of the Open Fund of Tianjin Central Hospital of Gynecology Obstetrics/Tianjin Key Laboratory of human development and reproductive regulation (2019XHZ10).


Conflicts of Interest: All authors have completed the ICMJE uniform disclosure from (available at The authors have no conflicts of interests to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The local ethics committee approved the study protocol (No. 2019KY038). Eligible patients received oral and written information and provided signed consent forms.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:


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Cite this article as: Yu Y, Peng F, Zhang Z. Using transperineal ultrasound to predict labor onset—reply. Ann Transl Med 2020;8(12):782. doi: 10.21037/atm-20-3918