Top-down proteomics—a near-future technique for clinical diagnosis?

Lidong He, Alan L. Rockwood, Archana M. Agarwal, Lissa C. Anderson, Chad R. Weisbrod, Christopher L. Hendrickson, Alan G. Marshall

Abstract

We thank Dr. Laszlo Prokai, Dr. Jae-Seok Kim, and Dr. Hyun Sik Kim for their insightful editorial commentaries on our recent publication “Diagnosis of hemoglobinopathy and β-thalassemia by 21 Tesla Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry of hemoglobin from blood” (1-3). As described by the editorial authors, 21 Tesla Fourier transform ion cyclotron resonance mass spectrometry (21 T FT-ICR MS) and top-down MS/MS set a new benchmark for precision diagnosis of hemoglobinopathies and thalassemia with fast sample preparation (dilute and infuse) and data acquisition (3 min).

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