Article Abstract

Epigallocatechin gallate in multiple system atrophy (PROMESA)

Authors: Kurt A. Jellinger

Abstract

Multiple system atrophy (MSA) is a rapidly progressing, fatal neurodegenerative disease of unclear etiology, clinically characterized by parkinsonism, cerebellar impairment, autonomous and motor dysfunctions in any combination due to degeneration of striatonigral, olivopontocerebellar and autonomous nervous systems (1,2). Pathological hallmarks are fibrillary α-synuclein (αSyn)-rich inclusions in oligodendroglia (glial cytoplasmic inclusions/GCIs) (3) that also rarely involve astrocytes and neurons (4).