Does elevated urinary Dkkopf-3 level predict vulnerability to kidney injury during cardiac surgery?

Matthew B. Lanktree, York Pei

Abstract

Acute kidney injury (AKI) occurs in approximately one quarter of patients undergoing cardiac surgery and is associated with increased short-term and long-term mortality, as well as prolonged time for mechanical ventilation, intensive care, and hospitalization (1,2). AKI is defined by a sudden decrease in glomerular filtration rate typically with reduced urine output over a time period of hours to days; many patients with AKI also require renal replacement therapy (RRT) including hemodialysis or continuous RRT.