Impact of circulating tumor DNA early detection and serial monitoring in the management of stage I to III colorectal cancer

Diana Bello Roufai, François-Clément Bidard


The temporal course and severity of metastasis to distant organs is a complex process depending on multiple features varying in different cancers and individuals. In patients previously treated for a localized tumor, the latency period before clinical evidence of metastatic relapse is made up of a sequence of events with unpredictable temporal kinetics (1).