Article Abstract

The novel and critical role of von Hippel-Lindau in nephron formation

Authors: Soyoung Park, So-mi Kang, Bum-Joon Park

Abstract

Loss of von Hippel-Lindau gene (VHL) causes rare genetic disorder, characterized by clear cell renal cell carcinoma (ccRCC), pheochromocytomas, and hemangioblastomas (blood vessel tumors) (1-5). Well confirmed role of VHL is an E3 ligase for hypoxia-induced factors (HIFs) under normaxia condition.

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