The novel and critical role of von Hippel-Lindau in nephron formation

Soyoung Park, So-mi Kang, Bum-Joon Park


Loss of von Hippel-Lindau gene (VHL) causes rare genetic disorder, characterized by clear cell renal cell carcinoma (ccRCC), pheochromocytomas, and hemangioblastomas (blood vessel tumors) (1-5). Well confirmed role of VHL is an E3 ligase for hypoxia-induced factors (HIFs) under normaxia condition.