Standard of usual care defines effectiveness of early goal directed therapy

Sepsis is a leading cause of mortality and morbidity globally (1). Unfortunately, given wide variations in practices and resources available, there are significant variations in outcomes among different regions of the world (2). Ever since the seminal study was done by Rivers et al. demonstrated that patients with severe sepsis and septic shock warrant early, goal-directed care (3), there has been a paradigm shift on how this disease state is managed.