Do hypofraction and large breast size reciprocally fit in breast cancer radiotherapy?

Pierfrancesco Franco, Sara Bartoncini, Stefania Martini, Giuseppe Carlo Iorio, Umberto Ricardi


At present, postoperative whole breast irradiation (WBI) is standard of care for early-stage breast cancer patients (EBC) after breast conserving surgery (BCS), leading to a reduction in terms of both ‘any breast cancer recurrence’ and ‘breast-cancer mortality’ (1,2). With respect to fractionation, hypofractionated WBI has been tested within 4 prospective randomised controlled trials, reporting robust and reliable long-term local control and survival, toxicity profile and cosmetic outcome (3).