Another one in the chamber: cabozantinib for patients with metastatic non clear cell renal cell carcinoma

Vincenzo Di Nunno, Francesco Massari, Veronica Mollica, Alessia Cimadamore, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Rodolfo Montironi


The term ‘’Non-clear cell Renal Cell Carcinoma (nccRCC)’’ recognized a large series of renal tumours characterized of a specific genomic and morphological signature. Compared to clear cell renal cell carcinoma (ccRCC), these tumours are uncommon diagnoses with an overall incidence around 20–25% of primary kidney tumours) (1).