Article Abstract

Key players of neuroendocrine differentiation in prostate cancer

Authors: Matteo Santoni, Gaetano Aurilio, Alessandro Maccioni, Franco Nolè, Nicola Battelli

Abstract

We read with interest the article entitled “Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer” recently published by Reina-Campos et al. on Cancer Cell (1), in which a pathogenetic hypothesis focusing on the protein kinase C (PKC)λ/ι loss that would favor the acquisition of neuroendocrine (NE) differentiation in prostate cancer (PC) models has been investigated.