Treatment, complications, and outcomes of metastatic disease of the spine: from Patchell to PROMIS
Review Article

Treatment, complications, and outcomes of metastatic disease of the spine: from Patchell to PROMIS

Alexander T. Yahanda, Jacob M. Buchowski, Adam M. Wegner

Department of Orthopedic Surgery, Washington University, St. Louis, Missouri, USA

Contributions: (I) Conception and design: All authors; (II) Administrative support: JM Buchowski; (III) Provision of study materials or patients: JM Buchowski; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

Correspondence to: Jacob M. Buchowski, MD, MS. Department of Orthopaedic Surgery, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., Campus Box 8233, St. Louis, MO 63110, USA. Email:

Abstract: Spinal metastases are common in patients with cancer. As cancer treatments improve and these patients live longer, the number who present with metastatic spine disease will increase. Treatment strategies for these patients continues to evolve. In particular, since the prospective randomized controlled study in 2005 by Patchell et al. showed increased survival with decompressive surgical treatment of spinal metastases, there is a growing body of literature focusing on surgical management and complications of surgery for this disease. Surgery is often one component of a multimodal treatment approach with chemotherapy and radiation, which makes it difficult to parse the benefits of each individual treatment in outcome studies. Additionally, there has been more recent emphasis placed on patient-reported outcomes (PRO) after treatment for metastatic spine disease. In this review, we summarize treatments of metastatic spinal disease, possible perioperative complications, and validated tools used to assess outcomes for these patients.

Keywords: Metastasis; patient reported outcome measures; spine

Submitted Mar 18, 2019. Accepted for publication Apr 26, 2019.

doi: 10.21037/atm.2019.04.83


The spine is a common location of metastasis for many types of cancer. Some studies have estimated that over 30% of cancer patients will develop metastatic spine disease (1,2). Moreover, as treatments of primary cancers continue to improve, and as cancer patients consequently live longer, the number of patients with spinal metastases will increase. These tumors can have debilitating effects on quality of life and yield complex neurological sequelae as a result of spinal cord compression. The management of spinal metastases continues to evolve, with an expanding importance of surgical management of these patients. This shift in treatment paradigms was spurred by Patchell et al. (3), who demonstrated increased survival with surgery in a landmark randomized controlled trial comparing surgical decompression and radiation vs. radiation alone for compressive spinal metastases. A bourgeoning body of literature on outcomes and complications of surgery for spinal metastases has followed. Surgery is often one component of a multimodal approach to spinal metastases, often coupled with chemotherapy and radiation. This makes it more challenging for outcomes studies to determine the true benefit of individual treatments. There is also a growing body of literature attempting to discern the most effective means by which to assess patient-reported outcomes (PRO) after surgery. This review will summarize recent data on treatment of spinal metastatic disease, complications resulting from surgery, and the evolution of tools used to assess patient reported outcomes in these patients.

Treatment of spinal metastases

To understand treatment of spinal metastases, one must understand the advantages and limitations of medical management, radiotherapy, and surgical treatment. In practice, these modalities are most often used together rather than in isolation.

Medical management

Chemotherapy is usually employed to gain long-term control of spinal metastases. It is less often used as monotherapy unless metastases arise from exceedingly chemosensitive tumors such as lymphoma, seminoma, or neuroblastoma. More frequently, chemotherapy is used as adjuvant therapy with radiotherapy (RT) or with surgery plus RT. The particular chemotherapeutic agent used depends on histology and other tumor-specific characteristics (4-6).

Corticosteroids are also a mainstay of treatment of spinal metastases and are thought to help alleviate vasogenic edema and decrease inflammation, which is especially beneficial in metastases producing spinal cord compression (7). Moreover, steroids may have a direct cytotoxic effect on certain hematological malignancies (myeloma and lymphoma) and, at times, breast cancer (5,6). Exact guidelines for using steroids for spinal metastases have not been established; dosing is generally decided on an ad hoc basis. Past trials have advocated both for using the minimal dose of steroids possible as well as treating with high-dose steroids (particularly when treatment also involves RT) (5,7). Transient improvements in ambulation may be seen after initiating steroids and some patients may remain on steroids long-term to reduce pain (6,7).


Traditionally, RT was the predominant treatment modality for spinal metastases. Even today, with mounting evidence supporting the importance of surgical intervention as part of management, RT remains a crucial component of the overall treatment algorithm. The primary goal of RT is generally to reduce pain from metastases, though it can also be used to achieve local control to treat or prevent neurological sequelae from spinal cord compression (6,8).

RT can be administered via conventional external beam radiation therapy (EBRT), stereotactic body radiation therapy (SBRT), or spine-specific stereotactic radiosurgery (SRS), depending on the patient’s treatment goals or other patient-specific factors (4,5,8).

EBRT, the most common form of RT, is regularly the first line of treatment for spinal metastases. A single standard-of-care radiation dose has not been definitively established and is often dependent on the radiosensitivity of the tumor subtype. The most common regimens are 8 Gy in a single fraction, 20 Gy in 5 fractions, and 30 Gy in 10 fractions (8). Past trials examining the efficacy of higher-dose multiple-fraction RT vs. lower-dose single-fraction RT have found mixed results. In a meta-analysis of 25 RT trials for bone metastases, Chow et al. (9) found no significant differences in pain relief rates between 8 Gy single-fraction and 20–30 Gy multiple-fraction RT regimens, though the retreatment rate was higher in the single-fraction group. Higher-dose multiple-fraction RT may produce superior results compared to lower-dose single-fraction RT, but this is also dependent on tumor histology (4,8). EBRT at a dose of 30 Gy in 10 fractions may achieve effective local control in certain metastases such as lymphoma, myeloma, breast cancer, prostate cancer, and germinoma (8). Such a protocol is thus commonly used for spine metastases. However, for radioresistant tumors such as sarcomas, colorectal cancer, malignant melanoma, and renal cell carcinoma, local control rates fail to reach 50% at this dosage (8). For these tumors there is increasing data that larger radiation doses, for instance 40 Gy over 20 fractions, may yield better control rates (4,8).

SBRT and SRS are more novel, targeted RT modalities that can focus a greater amount of radiation on a tumor while reducing radiation toxicity to the surrounding tissues (10,11). SBRT may be given in 2–5 fractions; SRS is often given as only a single dose. The ideal radiation dose and schedule for SBRT and SRS are less universally agreed upon compared to EBRT. Nevertheless, because these forms of RT can deliver a more concentrated dose of radiation, quantities up to three times higher than with EBRT may be given, which results in improved local control (4,10,11). Indeed, when compared to EBRT, this higher achievable radiation dose makes this modality of RT less dependent on the radiosensitivity/radioresistance of a tumor in order to alleviate disease burden (4). When to use SBRT or SRS in lieu of EBRT as first-line treatment is an area under active investigation. Also, under investigation is the role of heavy particle radiotherapy such as proton beam or carbon ion therapy for spinal metastases. Considerably more research is needed on this topic, but the proposed benefits of such radiotherapy would be akin to SBRT or SRS (higher radiation doses with less damage to surrounding tissues) (12).


Surgery is now recognized as an integral component of the treatment of spinal metastases. It may be used for several reasons: to address neurologic symptoms of spinal cord compression, to stabilize spinal instability, to reduce pain, to remove epidural tumor before SBRT or SRS, and to provide a histological tumor diagnosis (see Figure 1 for example) (4,6).

Figure 1 Preoperative full length and thoracic lateral plain films (A), sagittal T2 MRI (B, left), axial T2 MRI (B, right upper), and axial CT (B, right lower), and postoperative AP and lateral full-length plain films (C) of a 47-year-old female with metastatic breast cancer. The patient has a T10 compression fracture with cord compression resulting in mid back pain and thoracic myelopathy. Surgery was performed to decompress the spinal cord and provide stability to decrease pain.

A new emphasis on the importance of surgery for spinal metastases has developed over the past 10–15 years following the seminal 2005 study by Patchell et al. (3) that provided prospective, randomized controlled trial evidence supporting the use of decompressive surgery for such patients. In this trial, patients with spinal metastases were randomized to receive either surgery (n=50) followed by RT or RT alone (n=51). A statistically significant difference in mean survival was seen between the two groups, with patients receiving surgery followed by RT surviving 126 days as compared to 100 days in the group that received RT alone (P=0.033). Additionally, neurological functioning, as determined by ASIA and Frankel scales, was sustained for 566 days on average in the surgery plus RT group vs. 72 days in the group receiving RT alone (P=0.001 for ASIA and P=0.0006 for Frankel). The ability to walk was significantly prolonged in patients who received surgery and RT instead of only RT (122 vs. 13 days; P=0.003), and more patients who were unable to ambulate at the study’s onset regained the ability to walk after surgery and RT compared to solely RT (62% and 19%, respectively; P=0.01). Continence was significantly prolonged (P=0.016) and significantly smaller doses of corticosteroids (P=0.0093) and opioid analgesics (P=0.002) were required in the group that received surgery. Surgery did not lead to prolonged hospitalization. Despite critiques that the trial excluded highly radiosensitive tumors and had a low enrollment rate, it provided convincing evidence of the benefits conferred by surgery. Indeed, because of the notably better outcomes in the surgery group, this study was halted early.

Following Patchell et al. there has been a bourgeoning body of literature that illustrates similar benefits of surgery (6,13-22). A study by Ibrahim et al. (18) helped to support the results of the Patchell trial. This prospective study examined outcomes for 223 patients who underwent surgery with or without radiotherapy and/or chemotherapy for spinal metastases of epithelial origin. After surgery, median survival was 11.7 months, 71% of patients had improved pain, 53% regained or maintained ambulation, and 39% regained urinary continence. As the authors noted, these results compared favorably to the most positive reported outcomes for patients treated by solely RT (23). Falicov et al. (16), in a study of 85 patients who underwent surgery for spinal metastases, concluded that surgery resulted in statistically significantly reduced levels of pain (P<0.00001) and improvements in patient-reported quality of life at 6 weeks (P=0.017), 3 months (P=0.039), and 6 months (P=0.013), with low complication rates. Thomas et al. (24) used the data from the Patchell trial and examined the cost-effectiveness of surgery and RT compared to RT alone for spinal metastases. These researchers determined that surgery plus RT was cost-effective with respect to both the cost per additional day of ambulation and the cost per life-year gained.

Though surgery is now a key aspect of management for spinal metastases, surgery alone is almost invariably palliative. The choice of surgery should depend on a patient’s goals for treatment, the number and location of metastases, and other individual patient characteristics (4-6,22). Surgery should be performed as soon as possible after diagnosis of metastases for optimal outcomes (25). Because its benefits are not immediate, surgery is most effective when a patient’s life expectancy is longer than 8–12 weeks and when the risks are outweighed by the potential improvements (6,26). At times, aggressive resection of metastases via en bloc resection has been shown to achieve high local control rates, but this does not completely preclude future metastases and is most effective for patients with a single metastasis (4-6,21). Moreover, many patients have spinal instability, poor neurological status, or goals of care that obviate en bloc resection, and these procedures are accompanied by relatively high morbidity (6,21). Debulking (when the tumor is resected in portions) or palliative (when the goal is primarily to reduce spinal cord compression) approaches may be used if en bloc resection is not possible (5,19,27). Stabilization can be performed to address spinal instability with or without accompanying decompression. Instrumentation is often depended on for long term stabilization, as there is often a high probability that the spine will not fuse properly around sites of metastases due to large gaps in bony structures, local bone destruction by the tumor, and radiotherapy and/or systemic therapy, which can interfere with the fusion process (see Figure 2 for example). We advocate for the use of bone graft or bone graft substitute to promote fusion, because fusion is possible in these patients despite unfavorable circumstances.

Figure 2 Preoperative lateral plan film and T1 MRI (A), lateral and coronal CT scan (B), and postoperative AP and lateral plain films of a 66-year-old male with metastatic bladder cancer who presented with difficulty breathing and progressive C5 level weakness after 3 days of XRT. A large gap in anterior bone, a lytic tumor, and XRT may contribute to decreased chance of fusion in this patient. XRT, X-ray technique.

Cement augmentation of vertebral bodies has also demonstrated efficacy, especially in patients with tumors in the anterior section of the spine (4-6,19). The use of cement augmentation through fenestrated screws is a newer trend that may prove similarly useful for mechanical strengthening of spinal constructs in bone that has been pathologically weakened by tumor (28,29). Spinal decompression may be via anterior or posterior approaches, with no consensus in the literature as to which is the superior approach (13,30). Recently, minimally invasive spine surgery has been shown to be a safe and effective technique for decompression and stabilization of the spine that may yield improved functional outcomes and quality of life (31-33).

Since surgery alone likely does not resolve a sufficient amount of tumor burden, it is often used in conjunction with pre- and/or postoperative RT. Research suggests that the timing between surgery and RT should be 1–2 weeks both before and after surgery in order to avoid spurring postsurgical complications (34,35).

Separation surgery is a newer approach by which spinal decompression is performed to create an advantageous opening to the tumor through which SBRT or SRS can deliver a more targeted dose of radiation (8,30,36). There are a number of approaches that can be used for separation surgery, but the transpedicular approach appears to be safe and the most versatile method for a wide range of tumor locations (4). The indications for postoperative RT are still the subject of some debate (37). A prior cost-utility analysis by Furlan et al. (38) concluded that while surgery plus RT was more expensive, this combination also generated superior outcomes to RT alone.

Kyphoplasty or vertebroplasty are more conservative treatments that may be used primarily to manage pain after compression fractures. These treatments can also help provide spine stability in the setting of lytic metastatic disease, particularly in patients with anterior spine instability and those undergoing RT (19).


Surgery for metastatic spine disease is subject to all the risks of non-oncologic spine surgery, with the added complicating factors of radiation, chemotherapy, coagulopathies, and medical fragility of oncology patients. A thorough understanding of the risks vs. potential benefits is required to make informed decisions about whether an operation is worth pursuing. A recent study of 647 patients undergoing a primary surgery for cervical, thoracic, or lumbar metastatic spine disease estimated a 32% 30-day complication rate after surgery, with 18% undergoing at least one reoperation (39). This is not insignificant, as these complications can potentially decrease quality of life after surgery, which is generally the primary goal. Experiencing a complication was also associated with decreased survival. Factors associated with developing complications were low albumin, additional comorbidities, pathologic fractures, three or more spine levels operated upon, or a combined surgical approach. These risk factors highlight the medical and surgical complexity of these patients that is often not modifiable.

Instrumentation failure is a known complication after surgery for spinal metastases. Abnormal biology in the area where fusion is desired may disrupt bone formation, and this can be further compounded by systemic chemotherapy or local radiation. Therefore, a majority of the forces may continue to be borne by instrumentation when fusion is not possible, due to either bone removal in a decompressive surgery or bone destruction by tumor. Instrumentation failure may become a more common complication as survival increases in these patients. A recent single center cohort study of 159 patients found a 1.9% rate of instrumentation failure requiring reoperation after surgery for metastatic spine disease, with previous radiation to the area being a significant risk (40). The mean survival after surgery of those without instrumentation failure was 17 months, so many patients succumbed to their disease before instrumentation may have failed. Another study of 318 patients at a single center reported a 2.8% instrumentation failure rate requiring reoperation, with chest wall resection and greater than six spinal levels of surgery being risk factors (41), and a third study of 289 patients had a 3.1% reoperation rate for instrumentation failure (42). Along with these factors, a systematic review found that positive sagittal balance and preoperative radiation may contribute to implant failures (43). Kumar et al. proposed a classification of these implant failures, dividing failures into early (<3 months) or late (>3 months), and then further subdividing based on whether the failure is symptomatic (44). The authors did not propose a full treatment algorithm; rather, they noted that there are a significant number of asymptomatic patients that may not need revision despite radiographic failure. They emphasized that surgery should be avoided with these patients to avoid further morbidity. This has been factored into the studies reported here, which only report instrumentation failure requiring reoperation and not asymptomatic failure.

Just as disruption of biology may affect fusion, it may also affect wound healing and increase risk for infection. One study from 2011 reported a very high rate of surgical site infection (SSI) after spine surgery for metastatic disease, up to 8.4% (45). Studies since then have found much lower SSI rates. In a cohort of 159 patients at a single center, 22 of 159 patients required reoperation due to wound dehiscence (6) or wound infection (16,46). Thromboembolic events and increasing number of levels were associated with reoperation in a multivariate model. Quraishi et al. found that infection was the most common reason for reoperation on 384 patients who underwent spine surgery for metastatic disease (42% of second procedures), with an overall infection rate of 4.5% (9/234) (42). A recent systematic review attempted to find risk factors for wound complications and preventative factors (43). After reviewing 40 articles, there was a low level of evidence that preoperative radiation, preoperative neurological deficit, revision surgery, and posterior approaches contribute to wound complications. Plastic surgery soft tissue reconstruction, intrawound vancomycin powder, and percutaneous pedicle screw instrumentation may be protective. As minimally invasive surgery and separation surgery techniques evolve, there may be the potential to further decrease wound complications through the use of tissue sparing techniques. The current literature does not contain a sufficient number of high-quality studies to support that hypothesis at this time (47).

Cost and value are becoming increasingly important factors for measuring outcomes of medical care. To that end, unplanned readmissions is an important metric that can have a significant impact on cost as well as serve as an indicator of morbidity associated with these procedures. Two recent single center studies of 164 and 159 patients looked at readmissions after surgery for metastatic spinal disease (48,49). Thirty-day readmission rates were from 13.8–16.8% and 1-year readmissions were 37.8–47.2%, with approximately 33% due to recurrent disease, 25% due to infection, and 37–43% as a result of medical complications. Prior hospitalization of 15 days and lung metastases were independent risk factors for readmission. Another single center study of 181 patients with both primary and metastatic tumors reported an overall perioperative complication rate or 21.0% with 11.9% 90-day readmissions, costing approximately $20,000 each (50).

Other factors that may affect complication rates include patient age and location of spinal metastases. In a multicenter study of 1,266 patients by the Global Spine Tumor Study group, increased age was associated with increased rates of complications (33.3% >80 years old, 23.9% 70–80 years old, and 17.9% <70 years old), with longer life expectancy in the youngest group and less neurologic recovery in the older group (51). From the American College of Surgeons National Surgical Quality Improvement Program database, cervical location of metastases are associated with highest risk of pulmonary complications and thoracic tumors are associated with highest risk of blood transfusion, whereas lumbosacral tumors have lower odds of perioperative mortality, pulmonary complications, and sepsis (52).

Blood transfusion is also associated with complications. In a single center study, the odds ratio of developing post-operative complications was 2.27 times higher in those who received a transfusion than in those who did not, with an increase in odds ratio of 1.24 per unit transfused (53). Transfusion is not associated with increased overall survival or disease-free survival (54). One method for decreasing transfusion rate is intraoperative cell salvage (IOCS) with a leukocyte depletion filter to remove malignant cells (55). IOCS can replace approximately 50% of the red blood cells lost during surgery while removing tumor cells. Recent advances in selective filtration have been demonstrated to be safe in oncologic surgery in gynecology, hepatobiliary surgery, gastrointestinal surgery, and urology, but there is a paucity of evidence in spinal metastatic disease. There is currently one study that reported lower blood transfusion rates and shorter lengths of stay with use of this technology in surgery for spinal metastases, with no difference in survival or complication rates (56). It will likely take more in depth and larger studies to establish this as a safe and effective technique in musculoskeletal tumor surgery.

Outcomes for spinal metastases

Survival and prognostic factors

Mean survival for spinal metastases is dependent on tumor histology and, depending on the study cited, may range from 51 months for myeloma to 26 months for thyroid cancer to less than 6 months for lung, stomach, esophagus, or pancreatic cancer (57,58). A number of studies (57-63) have attempted to identify prognosticators or use scoring systems to predict post-treatment survival in these patients. A systematic review and meta-analysis by Luksanapruksa et al. (64) identified seventeen prognosticators of poor outcomes across 43 studies, including factors such as age >65 years old, multiple metastases (bone or visceral), ≥3 involved vertebrae, non-ambulatory status before treatment, KPS <70, male gender, and increasing time from cancer diagnosis to surgery. Some commonly cited predictive systems are the Tomita, van der Linden, Bauer, modified Bauer, and revised Tokuhashi (58). These systems all incorporate various combinations of primary tumor characteristics, sites and number of metastases, neurological functioning metrics, or performance scores. The Bauer score and modified Bauer score were considered the most predictive scales (58,59), although recent studies (60,61) posit that a modified Bauer score that incorporates ambulatory status and serum albumin may be a significantly more accurate predictor than the modified Bauer scale alone. Regardless, treatment decisions, including whether or not to perform surgery, should not be guided solely by a prognostic model—they should be grounded in a patient’s symptoms, neurological compromise, and overall fitness.

Quality of life

Until relatively recently, most outcome measures for treatment of spinal metastases focused on survival, recurrence, complications, or measures of function or neurological status (65); less attention was paid to how patients characterized their own health. Consequently, there has been a push towards self-reported assessments of patients’ health and quality of life. Most of these data are accrued by assessing PRO via validated questionnaires (58). Some of these questionnaires are specific for spinal metastatic disease, while others may be designed more for patients with cancer or neck/back pain of any kind. Regarding more commonly used measures of quality of life for spinal metastases, the EuroQol 5-Dimensions (EQ-5D) is designed to elicit responses about patients’ health status in general. The Cancer Quality of Life Questionnaire Core 30 (QLQ-C30) also has been used, though this is a lengthy questionnaire and is not specific for spinal metastases. Because spinal metastases frequently cause neck and back pain, the Neck Disability Index (NDI) and the Oswestry Disability Index (ODI) have been used to assess quality of life, but these scales are also not specific for this patient population. To address these shortcomings, in 2010 the Spine Oncology Study Group created the Spine Oncology Study Group Outcome Questionnaire (SOSG-OQ), which was subsequently validated in 2015 specifically for patients with spinal metastases (65,66). The SOSG-OQ has since been lauded as more useful than older tools for assessing patient-reported quality of life (67).


The ideal PRO measuring tool is a scale that adapts to a patient’s responses in order to generate the most individually-crafted questionnaire. To this end, Computer Adaptive Testing (CAT) can offer a dynamic system that can generate specific questions based on patients’ prior answers to provide the most reliable and complete assessment (68-70). This kind of questionnaire is able to include metrics and incorporate patient characteristics that may not be captured by other PRO measurements such as the EQ-5D or the SOSG-OQ (70).

In 2004, the National Institutes of Health created the Patient-Reported Outcomes Measurement Information System (PROMIS) in order to improve patient self-reporting of symptoms, functioning, and quality of life (68). PROMIS utilizes Item Response Theory (IRT), which is a testing theory that ensures that each individual question is validated for application to the objective of the test as a whole (68). Moreover, PROMIS may be administered by computer to achieve the benefits of CAT. In sum, this ensures that PROMIS is a flexible and comprehensive assessment of PRO that can achieve greater accuracy while measuring a wide range of desired outcomes. PROMIS can also give T-scores for a patient’s reported outcomes, with a standardized mean score of 50 and a standard deviation of 10, which makes the output easier to understand and place into context alongside other patients (68,69).

PROMIS has been studied in patients with non-cancer spine conditions, where it has been shown to take less time to complete, have lower ceiling and floor effects, and to be just as valid when compared to more traditional, “static” spine PRO assessment scales (71). Few studies have used PROMIS specifically for metastatic spine disease. When the SOSG-OQ first was released in 2010, it was recommended by the SOSG for metastatic spine disease given its superior content capacity to measure disease burden (65) compared to other scales at that time. However, since then, PROMIS has often been lauded as the measurement tool of choice for PRO with spine metastases. Studies by Paulino Pereira et al. (67) and Bernstein et al. (72) compared PROMIS to other PRO questionnaires (ODI, NDI, EQ-5D, or SOSG-OQ) to assess pain and physical function for 100 and 51 patients, respectively, with spinal tumors. Both studies concluded that PROMIS was the superior measurement tool for most patient subgroups when compared to nearly every other PRO instrument. The one exception was that SOSG-OQ may be superior to PROMIS for measuring quality of life (67). Findings from Colman et al. (73), concluded that PROMIS was a superior and more responsive tool compared to EQ-5D, NDI, and ODI for assessing quality of life for 27 patients who underwent surgery and eight patients who underwent RT for spine tumors. Another study by van Wulfften Palthe et al. (74) compared PROMIS to number of older PRO measuring systems for patients with sacral spinal tumors, with the researchers recommending that PROMIS surveys be used to assess quality of life in areas such mental health, physical health, pain, gastrointestinal symptoms, sexual function, and social health. Given the comprehensiveness, efficiency, adaptability, and validity of PROMIS, the literature appears to be trending towards this becoming the gold standard for assessing PRO for metastatic spine disease. For measuring quality of life, both PROMIS and the SOSG-OQ may be used reliably.


Spinal metastases are a complex but common manifestation of primary cancers throughout the body. The management of these patients should incorporate individual patient and tumor characteristics, and most likely should involve a multifaceted approach involving radiation, chemotherapy, and surgery. Surgery, even despite its risks and complications, should be used whenever possible for these patients, as it can provide the longest added survival and superior relief of symptoms. There are many different prognostic variable or models that may predict some aspects of patient outcomes. With respect to measuring PRO after surgery, PROMIS currently seems to be the most favorable tool.




Conflicts of Interest: JM Buchowski receives royalty payments from Globus Medical and K2M and receives institutional fellowship fudning from OMeGA and AOSpine North America. The other authors have no conflicts of interest to declare.


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Cite this article as: Yahanda AT, Buchowski JM, Wegner AM. Treatment, complications, and outcomes of metastatic disease of the spine: from Patchell to PROMIS. Ann Transl Med 2019;7(10):216. doi: 10.21037/atm.2019.04.83